Stereoselective Synthesis of β,γ-Unsaturated Ketones by Acid-Mediated Julia-Type Transformation from 2-(1-Hydroxyalkyl)-1-alkylcyclopropanols

Abstract

An efficient transformation of 2-(1-hydroxyalkyl)-1-alkylcyclopropanols, obtained from α,β-unsaturated ketones, to β,γ-unsaturated ketones was achieved by trifluoroacetic acid (TFA)-mediated reaction.

β,γ-unsaturated ketone - methylene insertion - cyclopropanol - carbocation - stereoselective

References and Notes

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