Methods Inf Med 2007; 46(03): 376-385
DOI: 10.1160/ME0352
paper
Schattauer GmbH

Respiratory-phase Domain Analysis of Heart Rate Variability Can Accurately Estimate Cardiac Vagal Activity during a Mental Arithmetic Task

K. Kotani
1   Graduate School of Information Science and Technology, The University of Tokyo, Tokyo, Japan
,
M. Tachibana
2   Graduate School of Engineering, The University of Tokyo, Tokyo, Japan
,
K. Takamasu
2   Graduate School of Engineering, The University of Tokyo, Tokyo, Japan
› Author Affiliations
Further Information

Publication History

Publication Date:
20 January 2018 (online)

Summary

Objectives: The objectives of this paper were to present a method to extract the amplitude of RSA in the respiratory-phase domain, to compare that with subjective or objective indices of the MWL (mental workload), and to compare that with a conventional frequencyanalysis in terms of its accuracy during a mental arithmetic task.

Methods: HRV (heart rate variability), ILV (instantaneous lung volume), and motion of the throat were measured under a mental arithmetic experiment and subjective and objective indices were also obtained. The amplitude of RSA was extracted in the respiratory-phase domain, and its correlation with the load level was compared with the results of the frequencydomain analysis, which is the standard analysis of the HRV.

Results: The subjective and objective indices decreased as the load level increased, showing that the experimental protocol was appropriate. Then, the amplitude of RSA in the respiratory-phase domain also decreased with the increase in the load level. The results of the correlation analysis showed that the respiratory-phase domain analysis has higher negative correlations, −0.84 and −0.82, with the load level as determined bysimplecorrelation and rankcorrelation, respectively, than does frequencyanalysis, for which the correlations were found to be −0.54 and −0.63, respectively. In addition, it was demonstrated thatthe proposed method could be applied to the short-term extraction of RSA amplitude.

Conclusions: We proposed a simple and effective method to extract the amplitude of the respiratory sinus arrhythmia (RSA) in the respiratory-phase domain and the results show that this method can estimate cardiac vagal activity more accurately than frequency analysis.

 
  • References

  • 1 Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: standards of measurement, physiological interpretation, and clinical use. Circulation 1996; 93: 1043-65.
  • 2 Allen MT, Crowell MD. Patterns of autonomic response during laboratory stressors. Psychophysiology 1989; 26: 603-14.
  • 3 Hayano J, Mukai S, Sakakibara M, Okada A, Takata K, Fujinami T. Effect of respiratory interval on vagal modulation of heart rate. Am J Physiol 1994; 267: H33-H40.
  • 4 Katona PG, Jih F. Respiratory sinus arrhythmia: noninvasive measure of parasympathetic cardiac control. JAppl Physiol 1975; 39: 801-5.
  • 5 Pomeranz B, Macaulay RJB, Caudill MA, Kutz I, Adam D, Gordon D, Kilborn KM, Barger AC, Shannon DC, Cohen RJ, Benson H. Assessment of autonomic function in humans by heart rate spectral analysis. Am J Physiol 1985; 248: H151-3.
  • 6 Hoshikawa Y, Yamamoto Y. Effects of stroop color word conflict test on the autonomic nervous system responses. Am J Physiol 1997; 272: H1113-21.
  • 7 Suzuki S, Toyabe S, Moroda T, Tada T, Tsukahara A, Iiai T, Minagawa M, Maruyama S, Hatakeyama K, Endoh K, Abo T. Circadian rhythm of leucocytes and lymphocyte subsets and its possible correlation with the function of the autonomic nervous system. Clin. Exp. Immunol 1997; 110: 500-8.
  • 8 Ivanov PC, Amaral LAN, Goldberger AL, Havlin S, Rosenblum MG, Struzik ZR, Stanley HE. Multifractality in human heartbeat dynamics. Nature 1999; 399: 461-5.
  • 9 Kiyono K, Struzik ZR, Aoyagi N, Sakata S, Hayano J, Yamamoto Y. Critical scale-invariance in healthy human heart rate. Phys Rev Lett 2004; 93: 178103-1-4.
  • 10 Kotani K, Hidaka I, Yamamoto Y, Ozono S. Analysis of respiratory sinus arrhythmia with respect to respiratory phase. Methods Inf Med 2000; 39: 153-6.
  • 11 Svensson E, Angelborg-Thanderz ML. Sjöberg Mission challenge, mental workload and performance in military aviation. Aviat Space Environ Med 1993; 64: 985-91.
  • 12 Hart SG, Staveland LE. Development of NASATLX (Task Load Index): results of empirical and theoretical research. Human Mental Workload, Elsevier Science Publishers. 1988: 139-83.
  • 13 Han K, Nagel JH, Schneiderman N. A continuous representation of heart rate. Proc Ann Int Conf IEEE/EMBS 1992; 14: 785-6.
  • 14 Schäfer C, Rosenblum MG, Abel H-H, Kurths J. Synchronization in the human cardiorespiratory system. Phys Rev E 1999; 60: 857-70.
  • 15 Baumert M, Baier V, Haueisen J, Wessel N, Meyerfeldt U, Voss A. Forecasting of life threatening arrhythmias using the compression entropy of heartrate. Methods Inf Med 2004; 43: 202-6.
  • 16 Mainardi LT, Montano N, Cerutti S. Automatic decomposition of Wigner distribution and its application to heart rate variability. Methods Inf Med 2004; 43: 17-21.
  • 17 Lucini D, Norbiato G, Clerici M, Pagani M. Hemodynamic and autonomic adjustments to real life stress conditions in humans. Hypertension 2002; 39: 184-8.
  • 18 Hayano J, Sakakibara Y, Yamada A, Yamada M, Mukai S, Fujinami T, Yokoyama K, Watanabe Y, Takata K. Accuracy of assessment of cardiac vagal tone by heart rate variability in normal subjects. Am J Cardiol 1991; 67: 199-204.
  • 19 Gilad O, Swenne CA, Davrath LR, Akselrod S. Phase-averaged characterization of respiratory sinus arrhythmia pattern. Am J Physiol Heart Circ Physiol 2005; 288: 504-10.
  • 20 DeBoer RW, Karemaker JM, Strackee J. Hemodynamic fluctuation and baroreflex sensitivity in humans: a beat-to-beat model. Am J Physiol 1987; 253: H680-9.
  • 21 Kotani K, Takamasu K, Ashkenazy Y, Stanley HE, Yamamoto Y. Model for cardio-respiratory synchronization in humans. Phys Rev E 2002; 65: 051923-1-9.
  • 22 Pyetan E, Akselrod S. A theoretical appraisal of the dependence of respiratory sinus arrhythmia on gradual vagal blockade. Methods Inf Med 2004; 43: 52-5.
  • 23 Gianaros PJ, Quigley KS, Muth ER, Levine ME, Vasko Jr RC, Stern RM. Relationship between temporal changes in cardiac parasympathetic activity and motion sickness severity. Psychophysiology 2003; 40: 39-44.
  • 24 Yli-Hankala A, Porkkala T, Kaukinen S, Häkkinen V, Jäntti V. Respiratory sinus arrhythmia is reversed during positive pressure ventilation. Acta Physiol Scand 1991; 141: 399-407.
  • 25 Wang DY, Pomfrett CJD, Healy TEJ. Respiratory sinus arrhythmia: anew, objective sedation score. British Journal of Anaesthesia 1993; 71: 354-8.
  • 26 Watkins LL, Grossman P, Krishnan R, Sherwood A. Anxiety and vagal control of heart rate. Psychosom Med 1998; 60: 498-502.