Dirofilaria-repens-Befall bei einem Hund aus Mitteldeutschland ohne Reisevorbericht

Zusammenfassung

Bei einem mit Dyspnoe und Fieber vorgestellten Mischlingshund wurde nach Thoraxpunktion ein Pyothorax diagnostiziert und als Zufallsbefund eine Mikrofilarie festgestellt. Die durchgeführten diagnostischen Tests bestätigten eine Infektion mit Dirofilaria repens, die wahrscheinlich autochthon in Mitteldeutschland stattfand. Die im Abstand von 4 Wochen angewandte Therapie mit Moxidectin über 6 Monate erwies sich nach regelmäßiger Kontrolle als erfolgreich. Der Fallbericht zeigt, dass Dirofilaria-repens-Infektionen in Deutschland auftreten können und erfolgreich zu therapieren sind.

Summary

A mixed breed dog was presented with dyspnoea and fever. In the purulent thorax aspirate, a nematode larva was found during the cytological examination. Subsequent diagnostic tests revealed an infection with Dirofilaria repens, which was probably acquired autochthonously in central Germany. Moxidectin was administered every 4 weeks for 6 months and shown to be effective as indicated by subsequent blood examinations. This case report shows that infection with Dirofilaria repens is possible in Germany and can be treated successfully.

Schlüsselwörter

Thoraxpunktion - Dirofilaria repens - Parasitose - Moxidectin

Keywords

Thorax aspirate - Dirofilaria repens - parasitosis - moxidectin

• Literatur

• 1 Albanese F, Abramo F, Braglia C, Caporali C, Venco L, Vercelli A, Ghibaudo G, Leone F, Carrani F, Gianelli A, Otranto D. Nodular lesions due to infestation by Dirofilaria repens in dogs from Italy. Vet Dermatol 2013; 24: 255-e56.
• 2 Bazzocchi C, Mortarino M, Grandi G, Kramer LH, Genchi C, Bandi C, Genchi M, Sacchi L, McCall JW. Combined ivermectin and doxycycline treatment has microfilaricidal and adulticidal activity against Dirofilaria immitis in experimentally infected dogs. Int J Parasitol 2008; 38: 1401-1410.
• 3 Cancrini G, Yanchang Sun, Della ATorre, Coluzzi M. Influenza della temperatura sullo sviluppo larvale di Dirofilaria repens in diverse specie di zanzare. Parassitologia 1988; 30 (Suppl. 01) 38.
• 4 Cancrini G, Magi M, Gabrielli S, Arispici M, Tolari F, Dell’Omodarme M, Prati C. Natural vectors of dirofilariasis in rural and urban areas of the Tuscan region, central Italy. J Med Entomol 2006; 43 (03) 574-577.
• 5 Chandrasekharan NV, Karunanayake EH, Franzen L, Abeyewickreme W, Pettersson U. Dirofilaria repens: cloning and characterization of a repeated DNA sequence for the diagnosis of dirofilariasis in dogs, Canis familiaris . Exp Parasitol 1994; 78: 279-286.
• 6 Czajka C, Becker N, Jöst H, Poppert S, Schmidt-Chanasit J, Krüger A, Tannich E. Stable transmission of Dirofilaria repens nematodes, northern Germany. Emerg Infect Dis 2014; 20 (02) 329-331.
• 7 Demiaszkiewicz AW, Polanczyk G. Pierwszy w Polsce przypadek inwazji Dirofilaria repens u psa. Magazyn Weterynaryjny 2010; 19 (154) 254-256.
• 8 Demiaszkiewicz AW, Karamon J, Jasik A. Case of Dirofilaria repens in a testis of a dog. Medycyna Weterynaryjna 2013; 69 (02) 124-127.
• 9 Demiaszkiewicz AW, Polanczyk G, Osinska B, Pyziel AM, Kuligowska I, Lachowicz J, Sikorski A. Prevalence and distribution of Dirofilaria repens Railliet et Henry, 1911 in dogs in Poland. Pol J Vet Sci 2014; 17 (03) 515-517.
• 10 Favia G, Lanfrancotti A, Della ATorre, Canrini G, Coluzzi M. Polymerase chain reaction-identification of Dirofilaria repens and Dirofilaria immitis . Parasitology 1996; 113: 567-571.
• 11 Fok É, Jascó O, Szebeni Z, Györffy A, Sükösd L, Lukàcz Z, Schaper R. Elimination of Dirofilaria (Nochtiella) repens microfilariae in dogs with monthly treatments of moxidectin 2.5%/imidacloprid 10% (Advocate®, Bayer) spot on. Parasitol Res 2010; 106: 1141-1149.
• 12 Fortin JF, Slocombe JOD. Temperature requirements for the development of Dirofilaria immitis in Aedes triseriatus and Ae vexans . Mosquito News 1981; 41 (03) 625-633.
• 13 Genchi C, Rinaldi L, Cascone C, Mortarino M, Cringoli G. Is heartworm disease really spreading in Europe?. Vet Parasitol 2005; 133: 137-148.
• 14 Genchi C, Rinaldi L, Mortarino M, Genchi M, Cringoli G. Climate and Dirofilaria infection in Europe. Vet Parasitol 2009; 163: 286-292.
• 15 Genchi C, Mortarino M, Rinaldi L, Cringoli G, Traldi G, Genchi M. Changing climate and changing vector-borne disease distribution: The example of Dirofilaria in Europe. Vet Parasitol 2011; 176: 295-299.
• 16 Glaser B, Gothe R. Importierte arthropodenübertragene Parasiten und parasitische Arthropoden beim Hund. Erregerspektrum und epidemiologische Analyse der 1995/96 diagnostizierten Fälle. Tierärztl Prax 1998; 26 (K): 40-46.
• 17 Grandi G, Quintavalla C, Mavropoulou A, Genchi M, Gnudi G, Bertoni G, Kramer L. A combination of doxycycline and ivermectin is adulticidal in dogs with naturally acquired heartworm disease (Dirofilaria immitis). Vet Parasitol 2010; 169: 347-351.
• 18 Hermosilla C, Pantchev N, Dyachenko V, Gutmann M, Bauer C. First autochthonous case of canine ocular Dirofilaria repens infection in Germany. Vet Rec 2006; 158: 134-135.
• 19 Hoerauf A, Nissen-Pähle K, Schmetz C, Henkle-Dührsen K, Blaxter ML, Büttner DW, Gallin MY, Al-Qaoud KM, Lucius R, Fleischer B. Tetracycline therapy targets intracellular bacteria in the filarial nematode Litomosoides sigmodontis and results in filarial infertility. J Clin Invest 1999; 103: 11-18.
• 20 Hoerauf A, Volkmann L, Hamelmann C, Adjei O, Autenrieth IB, Fleischer B, Büttner DW. Endosymbiotic bacteria in worms as targets for a novel chemotherapy in filariasis. Lancet 2000; 355: 1242-1243.
• 21 Kartashev V, Batashova I, Kartashov S, Ermakov A, Mironova A, Kuleshova Y, Ilyasov B, Kolodiy I, Klyuchnikov A, Ryabikina E, Babicheva M, Levchenko Y, Pavlova R, Pantchev N, Morchon R, Simon F. Canine and human dirofilariosis in the Rostov region (southern Russia). Vet Med Int. 2011 Article ID 685713.
• 22 Kronefeld M, Kampen H, Sassnau R, Werner D. Molecular detection of Dirofilaria immitis, Dirofilaria repens and Setaria tundra in mosquitoes from Germany. Parasit Vectors 2014; 07: 30.
• 23 Löwenstein M, Spallinger E. Erster autochthoner Fall einer Dirofilaria (Nochtiella) repens Infektion bei einem Hund in Österreich – ein Fallbericht. Wien Tierärztl Mschr – Vet Med Austria 2009; 96: 184-187.
• 24 Magi M, Calderini P, Gabriella S, Dell’Omodarme M, Macchioni F, Prati MC, Cancrini G. Vulpes vulpes: A possible wild reservoir for zoonotic filariae. Vector Borne Zoonotic Dis 2008; 08 (01) 1-4.
• 25 Magi M, Macchioni F, Dell’Omodarme M, Prati MC, Calderini P, Gabriella S, Iori A, Cancrini G. Endoparasites of red fox (Vulpes vulpes) in Central Italy. J Wildlife Dis 2009; 45 (03) 881-885.
• 26 Magnis J, Lorentz S, Guardone L, Grimm F, Magi M, Naucke TJ, Deplazes P. Morphometric analysis of canine blood microfilariae isolated by the Knott’s test enables Dirofilaria immitis and Drepens species-specific and Acanthocheilonema (syn. Dipetalonema) genus-specific diagnosis. Parasit Vectors 2013; 06: 48.
• 27 Marconcini A, Magi M, Macchioni G, Sassetti M. Filarioses in foxes in Italy. Vet Res Comm 1996; 20: 316-319.
• 28 Masny A, Lewin T, Salamatin R, Golab E. Autochthonous canine Dirofilaria repens in the vicinity of Warsaw. Pol J Vet Sci 2011; 14 (04) 659-661.
• 29 McCall JW, Jun JJ, Bandi C. Wolbachia and the antifilarial properties of tetracycline. An untold story. Ital J Zool 1999; 66: 7-10.
• 30 McCall JW. The safety-net story about macrocyclic lactone heartworm preventives: A review, an update, and recommendations. Vet Parasitol 2005; 133: 197-206.
• 31 McCall JW, Genchi C, Kramer L, Guerrero J, Dzimianski MT, Supakorndej P, Mansour AM, McCall SD, Supakorndej N, Grandi G, Carson B. Heartworm and Wolbachia: Therapeutic implications. Vet Parasitol 2008; 158: 204-214.
• 32 McGreevy PB, Theis JH, Lavoipierre MMJ, Clark J. Studies on filariasis III. Dirofilaria immitis: emergence of infective larvae from the mouthparts of Aedes aegypti . J Helminthol 1974; 48: 221-228.
• 33 Medlock JM, Barrass I, Kerrod E, Leach S. Analysis of climatic predictions for extrinsic incubation of Dirofilaria in the United Kingdom. Vector Borne Zoonotic Dis 2007; 07 (01) 4-14.
• 34 Otranto D, Capelli G, Genchi C. Changing distribution patterns of vector borne diseases in Italy: leishmaniosis vs. dirofilariosis. Parasit Vectors 2009; 02 (Suppl. 01) S2.
• 35 Otranto D, Brianti E, Gaglio G, Dantas-Torres F, Azzaro S, Giannetto S. Short report: Human ocular infection with Dirofilaria repens (Railliet und Henry, 1911) in an area endemic for canine dirofilariasis. Am J Trop Med Hyg 2011; 84 (06) 1002-1004.
• 36 Overgaauw P, van Dijk E. Autochthonous case of Dirofilaria repens in a dog in the Netherlands. Vet Rec 2009; 164: 158.
• 37 Pampiglione S, Canestri GTrotti, Rivasi F. Human dirofilariasis due to Dirofilaria (Nochtiella) repens: A review of world literature. Parassitologia 1995; 37: 149-193.
• 38 Pampiglione S, Rivasi F. Human dirofilariasis due to Dirofilaria (Nochtiella) repens: an update of world literature from 1995 to 2000. Parassitologia 2000; 42: 231-254.
• 39 Pampiglione S, Rivasi F, Angeli G, Boldorini R, Incensati RM, Pastormerlo M, Pavesi M, Ramponi A. Dirofilariasis due to Dirofilaria repens in Italy, an emergent zoonosis: report of 60 new cases. Histopathol 2001; 38: 344-354.
• 40 Pantchev N, Norden N, Lorentzen L, Rossi M, Rossi U, Brand B, Dyachenko V. Current surveys on the prevalence and distribution of Dirofilaria spp. in dogs in Germany. Parasitol Res 2009; 105: 63-74.
• 41 Pantchev N, Etzold M, Daugschies A, Dyachenko V. Diagnosis of imported canine filarial infections in Germany 2008–2010. Parasitol Res 2011; 109: 61-76.
• 42 Rishniw M, Barr SC, Simpson KW, Frongillo MF, Franz M, Alpizar JLD. Discrimination between six species of canine microfilariae by a single polymerase chain reaction. Vet Parasitol 2006; 135: 303-314.
• 43 Rossi L, Pollono F, Meneguz PG, Gribaudo L, Balbo T. An epidemiological study of canine filariosis in north-west Italy: What has changed in 25 years?. Vet Res Comm 1996; 20: 308-315.
• 44 Salamatin RV, Pavlikovska TM, Sagach OS, Nikolayenko SM, Kornyushin VV, Kharchenko VO, Masny A, Cielecka D, Konieczna-Salamatin J, Conn DB, Golab E. Human dirofialariasis due to Dirofilaria repens in Ukraine, an emergent zoonosis: epidemiological report of 1465 cases. Acta Parasitologica 2013; 58 (04) 592-598.
• 45 Sassnau R, Dyachenko V, Pantchev N, Stöckel F, Dittmar K, Daugschies A. Dirofilaria-repens-Befall in einem Schlittenhunde-Rudel im Land Brandenburg. Diagnose und Therapie der kaninen kutanen Dirofilariose. Tierärztl Prax 2009; 37 (K): 95-101.
• 46 Sassnau R, Daugschies A, Lendner M, Genchi C. Climate suitability for the transmission of Dirofilaria immitis and D. repens in Germany. Vet Parasitol 2014; 205 (1–2): 239-245.
• 47 Svobodova Z, Svobodova V, Genchi C, Forejtek P. The first report of autochthonous dirofilariosis in dogs in the Czech Republic. Helminthol 2006; 43 (02) 242-245.
• 48 Tappe D, Plauth M, Bauer T, Muntau B, Dießel L, Tannich E, HerrmannTrost P. A case of autochthonous human Dirofilaria infection, Germany, March 2014. Euro Surveill. 2014 19. (17): pii=20790.
• 49 Tarello W. Cutaneous lesions in dogs with Dirofilaria (Nochtiella) repens infestation and concurrent tick-borne transmitted diseases. Vet Dermatol 2002; 13: 267-274.
• 50 Traversa D, Aste G, Mililli P, Capelli G, Pampurini F, Tunesi C, Santori D, Paoletti B, Boari A. Autochthonous foci of canine and feline infections by Dirofilaria immitis and Dirofilaria repens in central Italy. Vet Parasitol 2010; 169: 128-132.
• 51 Traversa D, Aste G, Di Cesare A, Paoletti B, Di Tommaso M, Di Giulio E, Pampurini F, Tunesi C, Boari A. Efficacy of a single administration of a spot-on solution containing imidacloprid10%/moxidectin 2.5% in eliminating Dirofilaria repens microfilariae in naturally infected dogs. Vet Parasitol 2011; 179: 107-112.
• 52 Trotz-Williams LA, Trees AJ. Systematic review of the distribution of the major vector-borne parasitic infections in dogs and cats in Europe. Vet Rec 2003; 152: 97-105.
• 53 Venco L, Valenti V, Bertazzolo W, Genchi M, Genchi G. A mini-invasive procedure for removal of adult Dirofilaria repens from subcutaneous nodules in dogs. Intern J Appl Res Vet Med 2011; 09 (02) 217-223.
• 54 Webber WAF, Hawking F. Experimental maintenance of Dirofilaria repens and Dimmitis in dogs. Exp Parasit 1955; 04: 143-164.
• 55 Zahler M, Glaser B, Gothe R. Eingeschleppte Parasiten bei HundenDirofilaria repens und Dipetalonema reconditum . Tierärztl Prax 1997; 25: 388-392.