Positive correlation between functional disability, excessive daytime sleepiness, and fatigue in relapsing-remitting multiple sclerosis

Douglas Martins Braga; Gilmar Fernandes do Prado; Denis Bernardi Bichueti; Enedina Maria Lobato de Oliveira

doi:10.1590/0004-282X20160069

Arquivos de Neuro-Psiquiatria, Table of Contents

CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2016; 74(06): 433-438
DOI: 10.1590/0004-282X20160069

ARTICLE

Positive correlation between functional disability, excessive daytime sleepiness, and fatigue in relapsing-remitting multiple sclerosis

Correlação positiva entre incapacidade funcional, sonolência excessiva diurna e fadiga na forma recorrente-remitente da esclerose múltipla

Authors

Douglas Martins Braga

Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, Setor de Doenças Desmielizantes e Neuro-sono, São Paulo SP, Brasil.
Gilmar Fernandes do Prado

Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, Setor de Doenças Desmielizantes e Neuro-sono, São Paulo SP, Brasil.
Denis Bernardi Bichueti

Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, Setor de Doenças Desmielizantes e Neuro-sono, São Paulo SP, Brasil.
Enedina Maria Lobato de Oliveira

Universidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, Setor de Doenças Desmielizantes e Neuro-sono, São Paulo SP, Brasil.

Abstract

ABSTRACT

Sleep disorders in patients with multiple sclerosis have various causes and interfere with daytime wakefulness. This study assessed the correlation between fatigue, excessive daytime sleepiness and level of disability.

Method Retrospective review of medical records from patients with multiple sclerosis to collect data on severity of fatigue, disability, daytime sleepiness, and depression. From 912 medical records reviewed, 122 reported daytime sleepiness: 67% had relapsing remitting, 12% had primary progressive, and 21% had secondary progressive.

Results In 95% of the patients with relapsing remitting who complained of daytime sleepiness and fatigue, association was found between these symptoms and neurological disability. Patients with relapsing remitting who complained of daytime sleepiness and fatigue also experienced depression (p = 0.001). No association between fatigue, excessive daytime sleepiness, depression, and disability was found in patients with progressive disease.

Conclusion In relapsing remitting, there is correlation between functional disability, excessive daytime sleepiness and fatigue, a finding not confirmed in primary progressive and secondary progressive form.

RESUMO

Os distúrbios do sono em pacientes com esclerose múltipla são multifatoriais e interferem no alerta diurno. O objetivo deste estudo foi verificar a correlação entre a fadiga, sonolência excessiva diurna e nível de incapacidade.

Método Estudo retrospectivo de prontuários de pacientes com esclerose múltipla, onde foram coletados dados sobre gravidade da fadiga, nível de incapacidade, sonolência diurna e depressão. Dos 912 prontuários analisados, 122 apresentaram queixa de sonolência excessiva, divididos 67% forma recorrente-remitente; 12% forma primariamente progressiva; 21% forma secundariamente progressiva.

Resultados 95% dos pacientes recorrente remitente apresentaram sonolência excessiva diurna e fadiga, foi observada associação entre estes sintomas e incapacidade neurológica. Nos pacientes recorrentes remitentes observamos sonolência excessiva diurna, fadiga e depressão (p = 0,001). Nas formas progressivas não foi possível observar associação entre fadiga, sonolência excessiva diurna, depressão e incapacidade.

Conclusão Na forma remitente recorrente existe uma relação entre incapacidade funcional, sonolência excessiva diurna e fadiga, entretanto, não notamos esta associação nas formas secundariamente progressiva e primariamente progressiva.

multiple sclerosis - disabled persons - fatigue - disorders of excessive sonnolence

esclerose múltipla - pessoas com deficiênica, fadiga - distúrbios do sono por sonolência excessiva

Full Text

References

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