Journal of Pediatric Neurology 2009; 07(01): 079-083
DOI: 10.3233/JPN-2009-0275
Review Article
Georg Thieme Verlag KG Stuttgart – New York

Levetiracetam in the treatment of neonatal seizures

Autor*innen

  • Cynthia Sharpe

    a   Department of Pediatric Neurology, Starship Children's Hospital, Auckland, New Zealand
  • Richard H. Haas

    b   Division of Pediatric Neurology, University of California, San Diego, USA

Verantwortlicher Herausgeber dieser Rubrik:
Weitere Informationen

Publikationsverlauf

20. Dezember 2008

30. Dezember 2008

Publikationsdatum:
30. Juli 2015 (online)

Abstract

Levetiracetam has properties which make it a promising candidate for the treatment of neonatal seizures. The mechanism of action and evidence of broad spectrum clinical efficacy in adults and older children is reviewed along with the limited reported experience in neonates. The safety profile, pharmacokinetic properties and evidence of neuroprotective qualities are discussed together with the current status of pharmacokinetic studies in neonates.