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Journal of Pediatric Neurology 2010; 08(03): 299-310
DOI: 10.3233/JPN-2010-0407
DOI: 10.3233/JPN-2010-0407
Review Article
Stroke in sickle cell disease
Subject Editor:
Further Information
Publication History
26 July 2009
02 September 2009
Publication Date:
30 July 2015 (online)
Abstract
Sickle cell disease (SCD) is the second commonest cause of stroke in the pediatric population. Cerebrovascular complications in SCD may involve large or small vessels and present as large infarctions, intracranial or subarachnoid hemorrhage, moyamoya disease or silent infarcts. Predictors of stroke in SCD include high blood flow velocity on transcranial Doppler, low hemoglobin value, absence of alpha-thalassemia, high white cell count, hypertension, silent brain infarction, and a history of chest crisis. Regular blood transfusions are used for primary and secondary prevention of stroke in SCD. Other management strategies include stem cell transplantation,