Intracranial arterial aneurysms in children and young adults

Todd A. Abruzzo; Vincent DiNapoli; Ralph Rahme; Biraj Patel; Kevin O’Brien; Lincoln Jimenez; Ravishankar Shivashankar; James L. Leach; John J. Bissler; Blaise Jones

doi:10.3233/PNR-13070

Journal of Pediatric Neuroradiology, Table of Contents

Journal of Pediatric Neuroradiology 2013; 02(03): 203-235
DOI: 10.3233/PNR-13070

Review Article

Georg Thieme Verlag KG Stuttgart – New York

Intracranial arterial aneurysms in children and young adults

Todd A. Abruzzo

^aDepartment of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA

^bDepartment of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA

^dCincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

^eMayfield Clinic, Cincinnati, OH, USA

,

Vincent DiNapoli

^aDepartment of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA

,

Ralph Rahme

^aDepartment of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA

,

Biraj Patel

^bDepartment of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA

,

Kevin O’Brien

^bDepartment of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA

^dCincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

,

Lincoln Jimenez

^aDepartment of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA

^bDepartment of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA

,

Ravishankar Shivashankar

^aDepartment of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA

^bDepartment of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA

,

James L. Leach

^bDepartment of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA

^dCincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

,

John J. Bissler

^cDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA

,

Blaise Jones

^bDepartment of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA

^dCincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

› Author Affiliations
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Abstract

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Abstract

Intracranial arterial aneurysms are an important cause of hemorrhagic stroke during the first two decades of life. In the pediatric population, intracranial arterial aneurysms have a diverse etiological spectrum. The clinical course, response to treatment and long-term prognosis correlate strongly with the mechanism of lesion pathogenesis. A variety of phenotypes have been characterized, having variably overlapping features and differentiated according to the mechanism of pathogenesis: (1) idiopathic, (2) traumatic, (3) infectious, (4) flow related, (5) oncotic, (6) non-infectious inflammatory, (7) arteriopathic and (8) familial. The purpose of this report is to review intracranial aneurysmal disease in the pediatric population. We discuss contemporary approaches to diagnostic evaluation and clinical management, emphasizing interventional strategies and recent advances.

Keywords

Intracranial aneurysm - cerebral arterial diseases - arteriopathy - children

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