Mesenchymale Stromazellen auf dem Weg zur klinischen Anwendung: Update 2018

Zusammenfassung

Mesenchymale Stromazellen (MSC) besitzen ein großes therapeutisches Potenzial sowohl für Immunmodulation als auch regenerative Therapie. In einigen Indikationen, z. B. Behandlung der schweren Transplantat-gegen-Empfänger-Reaktion nach allogener Stammzelltransplantation, wurden MSC schon vor mehr als 10 Jahren therapeutisch eingesetzt. In weiteren Indikationen haben die MSC in den letzten Jahren nun das Stadium der klinischen Erprobung erreicht. Hier erfolgt eine Evaluation der Sicherheit und Wirksamkeit einer MSC-Therapie in einem sehr breiten Spektrum von Erkrankungen. Diese Übersichtsarbeit stellt den aktuellen Stand der präklinischen und klinischen Forschung zur Anwendung von MSC in der Behandlung der Transplantat-gegen-Empfänger-Reaktion, von Wundheilungsstörungen, von neurodegenerativen Erkrankungen und Knochen- und Knorpeldefekten dar.

Abstract

Mesenchymal stromal cells (MSC) show a high therapeutic potential in immunomudulation as well as in regenerative medicine. For some indications, e.g. treatment of severe graft-versus-host-disease following allogenic stem cell transplantation, MSC have already been tested for more than 10 years. For other indications, clinical application of MSC is under investigation to evaluate safety and efficacy of MSC treatment in a broad spectrum of diseases. This review presents recent pre-clinical and clinical research data on MSC on the treatment of graft-versus-host-disease, wound healing, neurodegenerative disorders and defects of bone and joint.

Schlüsselwörter

mesenchymale Stromazellen - translationale Medizin - Arzneimittel für neuartige Therapien (ATMP) - Knochenfraktur - neurodegenerative Erkrankungen - Transplantat-gegen-Empfänger-Reaktion (GvhD) - Wundheilung

Key words

mesenchymal stromal cells - translational medicine - advanced therapy medicinal product (ATMP) - bone fracture - neurodegenerative disease - graft-versus-host disease (GvhD) - wound healing

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