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Drug Res (Stuttg) 2019; 69(02): 93-99
DOI: 10.1055/a-0647-1765
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Modified Fe3O4/HAp Magnetically Nanoparticles as the Carrier for Ibuprofen: Adsorption and Release Study

Sarvin Mohammadi-Aghdam
1   Department of Chemistry, Payame Noor University, Tehran, Iran
,
Bahareh Valinezhad-Saghezi
2   College of Chemistry, University of Kurdistan, Kurdistan, Iran.
,
Yousef Mortazavi
3   Pramedicine Faculty, Anesthesiology and Operation Department, Babol University of Medical Sciences, Babol, Iran
,
Seyedeh Masoumeh Qhoreishi
4   Cellular and Molecular Biology Research Center, Health Research Institue, Babol University of Medical Science, Babol, Iran
› Author Affiliations
Further Information

Publication History

received 28 May 2018

accepted 20 June 2018

Publication Date:
11 July 2018 (online)

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Abstract

The adsorption capacity and release attributes of magnetic Fe3O4@hydroxyapatite (Fe3O4/HAp) nanoparticles for drug molecules can be improved by modified their surfaces with logical chosen organic groups. The internal surface of nanoparticles was functionalized with (3-aminopropyl) trimethoxysilane (APTS). Comparative studies of their adsorption and release properties for various model drug molecules (such as pure hydroxyapatite, Fe3O4@hydroxyapatite and functionalized Fe3O4@hydroxyapatite) were then conducted. The characteristic of the obtained materials was performed with X-ray-diffraction (XRD), energy dispersive X-ray microanalysis (EDS), fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), UV-Vis analysis, vibrating sample magnetometer (VSM) and transmission electron microscopy (TEM). Results show that functionalized magnetic Fe3O4@hydroxyapatite nanoparticles leads than a substantial decrease of the drug delivery rate in pH=6.8 after investigated drug release in intestine environment. In addition, the results demonstrate that high adsorption capacity for drug and slower drug release rate was obtained after functionalized nanoparticles than Fe3O4@hydroxyapatite and pure hydroxyapatite.

Key word

Drug delivery - Ibuprofen - APTS - Hydroxyapatite - Scanning electron microscopy
 

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