Introduction
Cystic lesions of the adrenal gland are infrequent entities. Few cases have been reported
worldwide, only as case reports or series [1]
[2]
[3]. Adrenal cysts are usually an incidental finding and represent approximately less
than 1 % of incidentally discovered adrenal lesions [1]. Most of these lesions present no symptoms, unless they grow substantially in size
(usually over 5 cm) or become complicated (hemorrhage, infection, or rupture). A major
issue about their management is their preoperative diagnosis, as imaging modalities
many times fail to determine their exact origin.
We report a case of a middle-aged patient with a retroperitoneal cystic lesion incidentally
discovered in the past, which was presumably arising from the pancreatic tail according
to previous imaging studies. She was inadequately followed up and referred to our
department for a different cause. During a detailed workup, we confirmed the presence
of the cystic lesion and performed endoscopic ultrasound (EUS) so as to further delineate
the cyst. Our endosonographers managed to depict the cystic lesion and proved its
origin from the adrenal gland.
Case report
A 47-year-old lady with symptoms of early satiety and flatulence referred to our department.
She had a past medical history of arterial hypertension and mentioned the presence
of a pancreatic cystic lesion incidentally diagnosed 9 years ago. The workup with
abdominal Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) revealed a
cyst containing solid components and measuring 11 × 8.4 cm, in close proximity to
the pancreas and left kidney, presumably arising from the pancreatic tail ([Fig. 1]). The cyst had significantly grown in size compared to previous scanning. Carbohydrate
antigen 19 – 9, carcinoembryonic antigen (CEA), and blood amylase were within normal
limits. EUS was decided prior to surgery and was performed with a curved linear Olympus
GF-UTC 180 echoendoscope. Surprisingly, EUS revealed a 12.5 cm × 8.5 cm well-defined
cyst arising from the left adrenal gland ([Fig. 2]). We could be confident that the lesion was originating from the adrenal, as EUS
enabled visualization of the pancreas and left kidney and was clearly separated from
them. It was confined by a thin wall and contained solid components and septa. We
shifted our processor (EU-ME2 Premier Plus, Olympus Medical Systems, Tokyo, Japan)
to harmonic software with a low mechanical index (0.15) and decided to proceed to
contrast agent administration (Sono-Vue 8 mL/vial, Bracco, Amsterdam, Holland). We
injected the microbubble agent as an intravenous bolus from a peripheral vein and
observed the lesion’s enhancement behavior for 120 seconds. We noticed that the cyst
did not uptake contrast except for its wall. Aspiration cytology analysis revealed
sparse mast cells and lymphocytes but no malignancy. Cystic fluid was serous, with
CEA and amylase levels within normal limits. We decided to verify the functional status
of the adrenal lesion preoperatively. The patient was referred to endocrinologist
and biochemical assessment with 24-h urine metanephrines, catecholamines, aldosterone,
17 hydrocorticosteroids, and 17 ketokosteroids was performed. Moreover, blood ACTH
(adrenocorticotropic hormone), DEAS (dehydroepiandrosterone), aldosterone, cortisol,
and plasma rennin activity levels were calculated and all were within normal limits.
The patient was referred to our multidisciplinary meeting in which surgery was decided.
During operation and due to significant encountered adhesions, the lesion could not
be easily resected and the patient needed to undergo peripheral pancreatectomy, splenectomy,
left adrenalectomy, nephrectomy, and segmental colectomy. Histopathologically, the
wall of the resected cyst composed of fibrous tissue along with entrapped adrenal
cortical and medullary cells, suggesting the diagnosis of an adrenal cyst. Differential
diagnosis included a pseudocyst with hemorrhagic content or an endothelial cyst of
lymphatic origin, since they both share common histological findings.
Fig. 1 Retroperitoneal cyst depicted on magnetic resonance imaging (white arrow).
Fig. 2 Large 12.5 × 8.5 cm cystic lesion arising from the left adrenal gland (white arrow)
depicted on endoscopic ultrasound.
Discussion
Adrenal cysts are very rare entities, mainly diagnosed in autopsy studies in 0.06 – 0.18 %
of the population [1]
[2]. They are classified into 4 categories: pseudocysts, endothelial cysts, infectious
cysts, and solid tumors with cystic degeneration. These cysts usually remain asymptomatic,
unless they become secretory, get complicated, or produce symptoms from pressure to
adjacent structures due to their growing size. Most commonly, these cysts present
in the fourth or fifth decade of life, as it was the case for our patient as well.
The incidence of malignancy in adrenal cystic lesions is less than 7 % and this is
largely related to their size, as adrenal cysts over 6 cm can carry an increased risk
for cancer [4]. Surgical treatment is strongly suggested for cysts larger than 5 cm or for complicated
ones [5].
Physicians should always keep in mind the adrenal-originated tumors in the differential
diagnosis of retroperitoneal lesions. We report a case of a massive retroperitoneal
cyst that was initially misdiagnosed as pancreatic cystic tumor. Despite improvements
on imaging, the origin of retroperitoneal tumors, especially the sizable ones, may
remain ambiguous. Usually, the initial imaging workup includes transabdominal ultrasound,
CT and MRI, which in many cases fail to detect the exact cystic origin and the patient
is led misdiagnosed to the surgical bed [4]
[5]
[6]. This can have an impact on the surgical procedure and to the patient’s clinical
outcome as well. A rare case of a large cystic pheochromocytoma was reported lately,
where EUS failed to determine its origin and was finally diagnosed intraoperatively
[6]. Another interesting case was that of a giant hemorrhagic cyst, where only contrast
enhanced transabdominal ultrasonography managed to determine the exact origin of the
lesion, compared to the inconclusive diagnosis of conventional ultrasound and CT [4].
Another clinically significant issue is that of the preoperative functional activity
of adrenal lesions. Usually, solid masses should be examined for secretory activity
with ACTH, aldosterone, androgens, metanephrines, and cortisol products (blood and
urines). Cystic masses very rarely present any secretory activity, but large cystic
masses when diagnosed as adrenal originated ones should always be investigated for
hormone production prior to surgery and especially if they present solid components
[7].
Conclusion
Retroperitoneal adrenal cystic lesions and especially the large ones are sometimes
very difficult to be accurately diagnosed preoperatively. EUS is an optimal method
for depiction of the adrenal gland and whenever available it could be a first-line
imaging modality for the evaluation of retroperitoneal cysts. This is the first report
in the literature that EUS proved to be superior to all other imaging studies for
preoperative diagnose of an adrenal cystic lesion.
