Download PDF
Int J Sports Med 2019; 40(03): 165-170
DOI: 10.1055/a-0828-8217
Physiology & Biochemistry
© Georg Thieme Verlag KG Stuttgart · New York

Cardiometabolic Response to a Single High-intensity Interval Exercise Session Versus Breaking up Sedentary Time with Fragmented High-intensity Interval Exercise

Daniel P. Bailey
1   Institute for Sport and Physical Activity Research, School of Sport Science and Physical Activity, University of Bedfordshire, Bedford, United Kingdom of Great Britain and Northern Ireland
,
Charlie J. Orton
1   Institute for Sport and Physical Activity Research, School of Sport Science and Physical Activity, University of Bedfordshire, Bedford, United Kingdom of Great Britain and Northern Ireland
,
Benjamin D. Maylor
1   Institute for Sport and Physical Activity Research, School of Sport Science and Physical Activity, University of Bedfordshire, Bedford, United Kingdom of Great Britain and Northern Ireland
,
Julia K. Zakrzewski-Fruer
1   Institute for Sport and Physical Activity Research, School of Sport Science and Physical Activity, University of Bedfordshire, Bedford, United Kingdom of Great Britain and Northern Ireland
› Author Affiliations
Further Information

Publication History



accepted 16 December 2018

Publication Date:
04 February 2019 (online)

Also available at
    Permissions and Reprints

Abstract

This study compared the effects of interrupting prolonged sedentary time with high-intensity physical activity (SED-ACT), a volume- and duration-matched high-intensity interval exercise session followed by prolonged sedentary time (HIIE), and prolonged uninterrupted sedentary time (SED) on postprandial glucose, insulin and triglyceride concentrations. Twelve sedentary and inactive but otherwise healthy adults completed 3, 6.5 h conditions in an incomplete counterbalanced order. During SED, participants sat continuously. For HIIE, participants completed 10×60 s cycling bouts at 90% maximum oxygen update (V̇O2max) with 1 min active recovery between bouts. In SED-ACT, 60 s cycling bouts at 90% V̇O2max were completed every 30 min (10 times in total) with 30 s of active recovery immediately before and after. Standardised meals were consumed at 0 h and 3 h and capillary blood samples were collected fasted and every 30 min. Compared with SED, postprandial glucose incremental area under the curve (iAUC) was significantly lower in SED-ACT by 1.91 mmol/L∙6.5 h (p=0.022) and triglyceride iAUC was significantly lower in HIIE by 1.02 mmol/L∙6.5 h (p=0.030). Interrupting sedentary time with high-intensity physical activity can lower postprandial glucose concentrations, whereas a HIIE session can lower postprandial triglyceride concentrations.

Key words

sedentary behaviour - physical activity - postprandial metabolism - glucose - lipids - lipids - HIT

Supplementary Material

 

  • References

  • 1 Adams OP. The impact of brief high-intensity exercise on blood glucose levels. Diabetes Metab Syndr Obes 2013; 6: 113-122
    PubMedGoogle Scholar
  • 2 Altenburg TM, Rotteveel J, Dunstan DW, Salmon J, Chinapaw MJ. The effect of interrupting prolonged sitting time with short, hourly, moderate-intensity cycling bouts on cardiometabolic risk factors in healthy, young adults. J Appl Physiol (1985) 2013; 115: 1751-1756
    CrossrefPubMedGoogle Scholar
  • 3 Bailey DP, Broom DR, Chrismas BC, Taylor L, Flynn E, Hough J. Breaking up prolonged sitting time with walking does not affect appetite or gut hormone concentrations but does induce an energy deficit and suppresses postprandial glycaemia in sedentary adults. Appl Physiol Nutr Metab 2016; 41: 324-331
    CrossrefPubMedGoogle Scholar
  • 4 Bailey DP, Locke CD. Breaking up prolonged sitting with light-intensity walking improves postprandial glycemia, but breaking up sitting with standing does not. J Sci Med Sport 2015; 18: 294-298
    CrossrefPubMedGoogle Scholar
  • 5 Bailey DP, Maylor BD, Orton CJ, Zakrzewski-Fruer JK. Effects of breaking up prolonged sitting following low and high glycaemic index breakfast consumption on glucose and insulin concentrations. Eur J Appl Physiol 2017; 117: 1299-1307
    CrossrefPubMedGoogle Scholar
  • 6 Bergouignan A, Latouche C, Heywood S, Grace MS, Reddy-Luthmoodoo M, Natoli AK, Owen N, Dunstan DW, Kingwell BA. Frequent interruptions of sedentary time modulates contraction- and insulin-stimulated glucose uptake pathways in muscle: Ancillary analysis from randomized clinical trials. Sci Rep 2016; 6: 32044
    CrossrefPubMedGoogle Scholar
  • 7 Bhammar DM, Sawyer BJ, Tucker WJ, Gaesser GA. Breaks in sitting time: Effects on continuously monitored glucose and blood pressure. Med Sci Sports Exerc 2017; 49: 2119-2130
    CrossrefPubMedGoogle Scholar
  • 8 Bhatnagar P, Wickramasinghe K, Williams J, Rayner M, Townsend N. The epidemiology of cardiovascular disease in the UK 2014. Heart 2015; 101: 1182-1189
    CrossrefPubMedGoogle Scholar
  • 9 Buchheit M, Laursen PB. High-intensity interval training, solutions to the programming puzzle. Sports Med 2013; 43: 927-954
    CrossrefPubMedGoogle Scholar
  • 10 Champion RB, Smith LR, Smith J, Hirlav B, Maylor BD, White SL, Bailey DP. Reducing prolonged sedentary time using a treadmill desk acutely improves cardiometabolic risk markers in male and female adults. J Sports Sci 2018; 36: 2484-2491
    CrossrefPubMedGoogle Scholar
  • 11 Chu A, Boutcher YN, Boutcher SH. Effect of acute interval sprinting exercise on postprandial lipemia of sedentary young men. J Exerc Nutrition Biochem 2016; 20: 9-14
    CrossrefPubMedGoogle Scholar
  • 12 Cohen J. Statistical Power Analysis for the Behavioral Sciences. 2nd ed. Hillsdale, NJ: Erlbaum; 1988
    Google Scholar
  • 13 Diabetes UK. Diabetes: Facts and Stats. 2015 https://www.diabetes.org.uk/Documents/Position %20statements/Diabetes %20UK %20Facts %20and %20Stats_Dec %202015.pdf Accessed 23 March 2016
    PubMed
  • 14 Dunstan DW, Kingwell BA, Larsen R, Healy GN, Cerin E, Hamilton MT, Shaw JE, Bertovic DA, Zimmet PZ, Salmon J, Owen N. Breaking up prolonged sitting reduces postprandial glucose and insulin responses. Diabetes Care 2012; 35: 976-983
    CrossrefPubMedGoogle Scholar
  • 15 Engeroff T, Fuzeki E, Vogt L, Banzer W. Breaking up sedentary time, physical activity and lipoprotein metabolism. J Sci Med Sport 2017; 20: 678-683
    CrossrefPubMedGoogle Scholar
  • 16 Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 2007; 39: 175-191
    CrossrefPubMedGoogle Scholar
  • 17 Gillen JB, Little JP, Punthakee Z, Tarnopolsky MA, Riddell MC, Gibala MJ. Acute high-intensity interval exercise reduces the postprandial glucose response and prevalence of hyperglycaemia in patients with type 2 diabetes. Diabetes Obes Metab 2012; 14: 575-577
    CrossrefPubMedGoogle Scholar
  • 18 Greiwe JS, Holloszy JO, Semenkovich CF. Exercise induces lipoprotein lipase and GLUT-4 protein in muscle independent of adrenergic-receptor signaling. J Appl Physiol (1985) 2000; 89: 176-181
    CrossrefPubMedGoogle Scholar
  • 19 Harriss DJ, Macsween A, Atkinson G. Standards for ethics in sport and exercise science research: 2018 update. Int J Sports Med 2017; 38: 1126-1131
    Article in Thieme ConnectPubMedGoogle Scholar
  • 20 Henson J, Davies MJ, Bodicoat DH, Edwardson CL, Gill JM, Stensel DJ, Tolfrey K, Dunstan DW, Khunti K, Yates T. Breaking up prolonged sitting with standing or walking attenuates the postprandial metabolic response in postmenopausal women: A randomized acute study. Diabetes Care 2016; 39: 130-138
    CrossrefPubMedGoogle Scholar
  • 21 Holloszy JO, Kohrt WM, Hansen PA. The regulation of carbohydrate and fat metabolism during and after exercise. Front Biosci 1998; 3: D1011-D1027
    CrossrefPubMedGoogle Scholar
  • 22 Latouche C, Jowett JB, Carey AL, Bertovic DA, Owen N, Dunstan DW, Kingwell BA. Effects of breaking up prolonged sitting on skeletal muscle gene expression. J Appl Physiol (1985) 2013; 114: 453-460
    CrossrefPubMedGoogle Scholar
  • 23 Lee CL, Kuo YH, Cheng CF. Acute high-intensity interval cycling improves postprandial lipid metabolism. Med Sci Sports Exerc 2018; 50: 1687-1696
    CrossrefPubMedGoogle Scholar
  • 24 Maylor BD, Zakrzewski-Fruer JK, Orton CJ, Bailey DP. Beneficial postprandial lipaemic effects of interrupting sedentary time with high-intensity physical activity versus a continuous moderate-intensity physical activity bout: A randomised crossover trial. J Sci Med Sport 2018; 21: 1250-1255
    CrossrefPubMedGoogle Scholar
  • 25 Mifflin MD, St Jeor ST, Hill LA, Scott BJ, Daugherty SA, Koh YO. A new predictive equation for resting energy expenditure in healthy individuals. Am J Clin Nutr 1990; 51: 241-247
    CrossrefPubMedGoogle Scholar
  • 26 Miyashita M. Effects of continuous versus accumulated activity patterns on postprandial triacylglycerol concentrations in obese men. Int J Obes (Lond) 2008; 32: 1271-1278
    CrossrefPubMedGoogle Scholar
  • 27 Miyashita M, Edamoto K, Kidokoro T, Yanaoka T, Kashiwabara K, Takahashi M, Burns S. Interrupting sitting time with regular walks attenuates postprandial triglycerides. Int J Sports Med 2016; 37: 97-103
    Article in Thieme ConnectPubMedGoogle Scholar
  • 28 O'Keefe JH, Bell DS. Postprandial hyperglycemia/hyperlipidemia (postprandial dysmetabolism) is a cardiovascular risk factor. Am J Cardiol 2007; 100: 899-904
    CrossrefPubMedGoogle Scholar
  • 29 Ortega JF, Fernandez-Elias VE, Hamouti N, Pallares JG, Mora-Rodriguez R. Higher insulin-sensitizing response after sprint interval compared to continuous exercise. Int J Sports Med 2015; 36: 209-214
    Article in Thieme ConnectPubMedGoogle Scholar
  • 30 Peddie MC, Bone JL, Rehrer NJ, Skeaff CM, Gray AR, Perry TL. Breaking prolonged sitting reduces postprandial glycemia in healthy, normal-weight adults: A randomized crossover trial. Am J Clin Nutr 2013; 98: 358-366
    CrossrefPubMedGoogle Scholar
  • 31 Poole DC, Jones AM. Measurement of the maximum oxygen uptake V̇o2max: V̇o2peak is no longer acceptable. J Appl Physiol (1985) 2017; 122: 997-1002
    CrossrefPubMedGoogle Scholar
  • 32 Pulsford RM, Stamatakis E, Britton AR, Brunner EJ, Hillsdon M. Associations of sitting behaviours with all-cause mortality over a 16-year follow-up: The Whitehall II study. Int J Epidemiol 2015; 44: 1909-1916
    CrossrefPubMedGoogle Scholar
  • 33 Saunders TJ, Atkinson HF, Burr J, MacEwen B, Skeaff CM, Peddie MC. The acute metabolic and vascular impact of interrupting prolonged sitting: A systematic review and meta-analysis. Sports Med 2018; 48: 2347-2366
    CrossrefPubMedGoogle Scholar
  • 34 Tan M, Chan Moy Fat R, Boutcher YN, Boutcher SH. Effect of high-intensity intermittent exercise on postprandial plasma triacylglycerol in sedentary young women. Int J Sport Nutr Exerc Metab 2014; 24: 110-118
    CrossrefPubMedGoogle Scholar
  • 35 Valdes CT, Elkind-Hirsch KE. Intravenous glucose tolerance test-derived insulin sensitivity changes during the menstrual cycle. J Clin Endocrinol Metab 1991; 72: 642-646
    CrossrefPubMedGoogle Scholar
  • 36 Wilmot EG, Edwardson CL, Achana FA, Davies MJ, Gorely T, Gray LJ, Khunti K, Yates T, Biddle SJ. Sedentary time in adults and the association with diabetes, cardiovascular disease and death: Systematic review and meta-analysis. Diabetologia 2012; 55: 2895-2905
    CrossrefPubMedGoogle Scholar
  • 37 Yang TJ, Wu CL, Chiu CH. High-intensity intermittent exercise increases fat oxidation rate and reduces postprandial triglyceride concentrations. Nutrients 2018; 10: E492
    CrossrefPubMedGoogle Scholar