Anti-Aging – gesundes Altern

Der Traum von der ewigen Jugend und die Suche nach deren Quelle sind so alt wie die Menschheit. Was vor über hundert Jahren mit heroischen medizinischen Selbstversuchen begann, wird im 21. Jahrhundert, meist im Internet und basierend auf neueren Erkenntnissen aus der Zellbiologie, vermarktet. Die vorliegende Arbeit gibt einen Überblick über die derzeit „heißesten“ Produkte auf dem Markt.

Abstract

Anti-aging products still are a big business worldwide. The most active promoters of anti-aging products currently are internet dealers, the cosmetic and the dairy industry or companies that sell nutritional supplements. Only a few of the advertised substances however have been studied in clinical trials under robust conditions. Several drugs demonstrate positive effects on intracellular mechanisms that are associated with delayed cellular aging. This does not mean that they are in delaying human aging. In contrast, key elements that provide successful healthy and long aging in humans are physical and mental activity a balanced, mediterranean diet and social contacts.

Schlüsselwörter

Anti-Aging - anabole Hormone - intrazelluläre Altersmechanismen - Biomarker des Alterns - gesundes Altern - Nahrungsergänzung

Key words

anti-Aging - anabolic hormones - intracellular aging mechanisms - biomarkers of aging - healthy aging - nutrition supplements

Publication History

Article published online:
14 April 2021

• Literatur

• 1 Liu H, Bravata DM, Olkin I. et al Systematic review: the safety and efficacy of growth hormone in the healthy elderly. Ann Intern Med 2007; 146: 104-115 . doi:10.7326/0003-4819-146-2-200701160-00005
• 2 Matfin G. The rejuvenation of testosterone: philosopher’s stone or Brown-Séquard Elixir?. Ther Adv Endocrinol Metab 2010; 1: 151-154 . doi:10.1177/2042018810385052
• 3 Srinivas N, Rachakonda S, Kumar R. Telomeres and Telomere Length: A General Overview. Cancers (Basel) 2020; 12: 558 . doi:10.3390/cancers12030558
• 4 Jaskelioff M, Muller FL, Paik J-H. et al Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature 2011; 469: 102-106 . doi:10.1038/nature09603
• 5 Haycock PC, Burgess S, Nounu A. et al Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study. JAMA Oncol 2017; 3: 636-651 . doi:10.1001/jamaoncol.2016.5945
• 6 Ernster L, Dallner G. Biochemical, physiological and medical aspects of ubiquinone function. Biochim Biophys Acta 1995; 1271: 195-204 . doi:10.1016/0925-4439(95)00028-3
• 7 Hernández-Camacho JD, Bernier M, López-Lluch G. et al Coenzyme Q(10) Supplementation in Aging and Disease. Front Physiol 2018; 9: 44 . doi:10.3389/fphys.2018.00044
• 8 Qu H, Guo M, Chai H. et al Effects of Coenzyme Q10 on Statin-Induced Myopathy: An Updated Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc 2018; 7: e009835 . doi:10.1161/JAHA.118.009835
• 9 Nogueiras R, Habegger KM, Chaudhary N. et al Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev 2012; 92: 1479-1514 . doi:10.1152/physrev.00022.2011
• 10 Semba RD, Ferrucci L, Bartali B. et al Resveratrol levels and all-cause mortality in older community-dwelling adults. JAMA Intern Med 2014; 174: 1077-1084 . doi:10.1001/jamainternmed.2014.1582
• 11 Weiskirchen S, Weiskirchen R. Resveratrol: How Much Wine Do You Have to Drink to Stay Healthy?. Adv Nutr 2016; 7: 706-718 . doi:10.3945/an.115.011627
• 12 Kulkarni AS, Brutsaert EF, Anghel V. et al. Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults. Aging cell 2018; 17
• 13 Glossmann HH, Lutz OMD. Metformin and Aging: A Review. Gerontology 2019; 65: 581-590 . doi:10.1159/000502257
• 14 Han Y, Xie H, Liu Y. et al Effect of metformin on all-cause and cardiovascular mortality in patients with coronary artery diseases: a systematic review and an updated meta-analysis. Cardiovasc Diabetol 2019; 18: 96 . doi:10.1186/s12933-019-0900-7
• 15 Kalus A. Xavier Naidoo und Adrenochrom: Was das „Wundermittel“ in Wirklichkeit ist. Im Internet (Stand: 05.02.2021): https://praxistipps.focus.de/xavier-naidoo-und-adrenochrom-was-das-wundermittel-in-wirklichkeit-ist_121431
• 16 Sourkes TL. The Biochemistry of Mental Disease. Can Med Assoc J 1961; 85: 487-490
• 17 Das SK, Roberts SB, Bhapkar MV. et al Body-composition changes in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE)-2 study: a 2-y randomized controlled trial of calorie restriction in nonobese humans. Am J Clin Nutr 2017; 105: 913-927 . doi:10.3945/ajcn.116.137232
• 18 Naghshi S, Sadeghi O, Willett WC. et al Dietary intake of total, animal, and plant proteins and risk of all cause, cardiovascular, and cancer mortality: systematic review and dose-response meta-analysis of prospective cohort studies. BMJ 2020; 370: m2412 . doi:10.1136/bmj.m2412
• 19 Eleftheriou D, Benetou V, Trichopoulou A. et al Mediterranean diet and its components in relation to all-cause mortality: meta-analysis. Br J Nutr 2018; 120: 1081-1097 . doi:10.1017/s0007114518002593
• 20 Bischoff-Ferrari HA, Vellas B, Rizzoli R. et al Effect of Vitamin D Supplementation, Omega-3 Fatty Acid Supplementation, or a Strength-Training Exercise Program on Clinical Outcomes in Older Adults: The DO-HEALTH Randomized Clinical Trial. JAMA 2020; 324: 1855-1868 . doi:10.1001/jama.2020.16909
• 21 Wachholz PA, Nunes VDS, Polachini do Valle A. et al Effectiveness of probiotics on the occurrence of infections in older people: systematic review and meta-analysis. Age Ageing 2018; 47: 527-536 . doi:10.1093/ageing/afy006
• 22 Maguire M, Maguire G. The role of microbiota, and probiotics and prebiotics in skin health. Arch Dermatol Res 2017; 309: 411-421 . doi:10.1007/s00403-017-1750-3
• 23 World Health Organization. World report on ageing and health. Geneva: WHO; 2015 Im Internet (Stand: 05.02.2021): https://www.who.int/ageing/publications/world-report-2015/en/
• 24 Roberts CE, Phillips LH, Cooper CL. et al Effect of Different Types of Physical Activity on Activities of Daily Living in Older Adults: Systematic Review and Meta-Analysis. J Aging Phys Act 2017; 25: 653-670 . doi:10.1123/japa.2016-0201