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Drug Res (Stuttg) 2020; 70(05): 183-187
DOI: 10.1055/a-1127-2960
Review
© Georg Thieme Verlag KG Stuttgart · New York

Dig & Delve into Protein Based Nanoformulations

Mohammad Shariq
1   Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
,
Saba Parveen
1   Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
,
Arshiya Shamim
1   Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
,
Farogh Ahsan 
1   Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
,
Poonam Kushwaha 
1   Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
,
Tarique Mahmood
1   Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India
› Author Affiliations
Further Information

Publication History

received 05 February 2020

accepted 24 February 2020

Publication Date:
16 March 2020 (online)

Also available at
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Abstract

Past few decades have emerged as the era of nanotechnology worldwide leading to an extensive research in pharmaceutical science as well as other fields. Nanoformulations have shown a promising future in therapeutics and theronostics. Protein based nanoformulations attracting attention in research as it can be used as therapeutics as well as carrier. Carrier based protein nanoformulatios are capable of accommodating range of therapeutics such as dyes, drugs, contrast agents and inorganic nanoclusters makings its application vast. The nano size of formulation enables it to reach the desired places by some modification. This paper reviewed the various protein based nanoformulation. Human serum albumin, Bovine serum albumin, soy protein isolate, phycocyanin, casein, bromelein, collagen and sericin based nanoformulations are briefly discussed. Various limitations of these proteins can be diminished by developing it in nano form and emerged as promising candidate as carrier as well as therapeutics in drug delivery advancements.

Key words

protein nanoformulations - nanoformulations - protein therapeutics
 

  • References

  • 1 Barreto JA, O’Malley W, Kubeil M. et al. Nanomaterials: Applications in cancer imaging and therapy. Adv Mater Weinheim 2011; 23: H18-H40
    CrossrefPubMedGoogle Scholar
  • 2 Li X, Mu J, Liu F. et al. Human transport protein carrier for controlled photoactivation of antitumor prodrug and real-time intracellular tumor imaging. Bioconjug Chem 2015; 26: 955-961
    CrossrefPubMedGoogle Scholar
  • 3 Zhou L, Yang T, Wang J. et al. Size- Tunable Gd2O3@albumin nanoparticles conjugating chlorin e6 for magnetic resonance imaging-guided photo-induced therapy. Theranostics 2017; 7: 764-774
    CrossrefPubMedGoogle Scholar
  • 4 Lohcharoenkal W, Wang L, Chen YC. et al. Protein nanoparticles as drug delivery carriers for cancer therapy. BioMed Research International. 2014: 1-12
    PubMedGoogle Scholar
  • 5 Golla K, Bhaskar C, Ahmed F. et al. A target-specific oral formulation of doxorubicin-protein nanoparticles: Efficacy and safety in hepatocellular cancer. Journal of Cancer 2013; 4: 644
    CrossrefPubMedGoogle Scholar
  • 6 Semalty A, Semalty M, Singh R. et al. Properties and formulation of oral drug delivery systems of protein and peptides. Indian Journal of Pharmaceutical Sciences 2007; 69: 741
    CrossrefPubMedGoogle Scholar
  • 7 Almeida AJ, Souto E. Solid lipid nanoparticles as a drug delivery system for peptides and proteins. Advanced Drug Delivery Reviews 2007; 59: 478-490
    CrossrefPubMedGoogle Scholar
  • 8 Matougui N, Boge L, Groo AC. et al. Lipid-based nanoformulations for peptide delivery. Int J Pharm 2016; 502: 80-97
    CrossrefPubMedGoogle Scholar
  • 9 Alvarez B, Carballal S, Turell L. et al. Formation and reactions of sulfenic acid in human serum albumin. In: Methods in Enzymology 2010; 473 pp 117-136 Academic Press
    PubMedGoogle Scholar
  • 10 Barbosa S, Taboada P, Mosquera V. Fibrillation and Polymorphism of Human Serum Albumin. In: Bio-nanoimaging. 2014 pp 345-362 Academic Press
    PubMedGoogle Scholar
  • 11 Langer K, Balthasar S, Vogel V. et al. Optimization of the preparation process for human serum albumin (HSA) nanoparticles. Int J Pharm 2003; 257: 169-180
    CrossrefPubMedGoogle Scholar
  • 12 Sheng Z, Hu D, Zheng M. et al. Smart human serum albumin-indocyanine green nanoparticles generated by programmed assembly for dual-modal imaging-guided cancer synergistic phototherapy. ACS Nano 2014; 8: 12310-12322
    CrossrefPubMedGoogle Scholar
  • 13 Dreis S, Rothweiler F, Michaelis M. et al. Preparation, characterisation and maintenance of drug efficacy of doxorubicin-loaded human serum albumin (HSA) nanoparticles. Int J Pharm 2007; 341: 207-214
    CrossrefPubMedGoogle Scholar
  • 14 Nogueira KA, Cecilia JA, Santos SO. et al. Adsorption behavior of bovine serum albumin on Zn–Al and Mg–Al layered double hydroxides. J Sol-Gel Sci Techn 2016; 80: 748-758
    CrossrefPubMedGoogle Scholar
  • 15 Zhao D, Zhao X, Zu Y. et al. Preparation, characterization, and in vitro targeted delivery of folate-decorated paclitaxel-loaded bovine serum albumin nanoparticles. Int J Nanomed 2010; 5: 669
    PubMedGoogle Scholar
  • 16 Bronze-Uhle ES, Costa BC, Ximenes VF. et al. Synthetic nanoparticles of bovine serum albumin with entrapped salicylic acid. Nanotechnology, Science and Applications 2017; 10: 11
    PubMedGoogle Scholar
  • 17 Singh P, Kumar R, Sabapathy SN. et al. Functional and edible uses of soy protein products. Comprehensive Reviews in Food Science and Food Safety 2008; 7: 14-28
    CrossrefPubMedGoogle Scholar
  • 18 Teng Z, Luo Y, Wang T. et al. Development and application of nanoparticles synthesized with folic acid conjugated soy protein. J Agric Food Chem 2013; 61: 2556-2564
    CrossrefPubMedGoogle Scholar
  • 19 Chen FP, Li BS, Tang CH. Nanocomplexation between curcumin and soy protein isolate: Influence on curcumin stability/bioaccessibility and in vitro protein digestibility. J Agric Food Chem 2015; 63: 3559-3569
    CrossrefPubMedGoogle Scholar
  • 20 Agrawal M, Yadav SK, Agrawal SK. et al. Nutraceutical phycocyanin nanoformulation for efficient drug delivery of paclitaxel in human glioblastoma U87MG cell line. J Nanopart Res 2017; 19: 272
    CrossrefPubMedGoogle Scholar
  • 21 Kunz C, Lönnerdal B. Human-milk proteins: analysis of casein and casein subunits by anion-exchange chromatography, gel electrophoresis, and specific staining methods. The American Journal of Clinical Nutrition 1990; 51: 37-46
    CrossrefPubMedGoogle Scholar
  • 22 Dalgleish DG. Casein micelles as colloids: surface structures and stabilities. J Dairy Sci 1998; 81: 3013-3018
    CrossrefPubMedGoogle Scholar
  • 23 Raj J, Uppuluri KB. Metformin loaded casein micelles for sustained delivery: formulation, characterization and in-vitro evaluation. Biomedical and Pharmacology Journal 2015; 8: 83-89
    PubMedGoogle Scholar
  • 24 Sharma M, Sharma R. Implications of designing a bromelain loaded enteric nanoformulation on its stability and anti-inflammatory potential upon oral administration. RSC Advances 2018; 8: 2541-2551
    CrossrefPubMedGoogle Scholar
  • 25 Di Lullo GA, Sweeney SM, Körkkö J. et al. Mapping the ligand-binding sites and disease-associated mutations on the most abundant protein in the human, type I collagen. J Biol Chem 2002; 277: 4223-4231
    CrossrefPubMedGoogle Scholar
  • 26 Bogue RH. Conditions affecting the hydrolysis of collagen to gelatin. Ind Eng Chem 1923; 15: 1154-1159
    CrossrefPubMedGoogle Scholar
  • 27 Lam PL, Kok SL, Bian ZX. et al. d-glucose as a modifying agent in gelatin/collagen matrix and reservoir nanoparticles for Calendula officinalis delivery. Colloids and Surfaces B: Biointerfaces 2014; 117: 277-283
    CrossrefPubMedGoogle Scholar
  • 28 Mandal BB, Kundu SC. Self-assembled silk sericin/poloxamer nanoparticles as nanocarriers of hydrophobic and hydrophilic drugs for targeted delivery. Nanotechnology 2009; 20: 355101
    CrossrefPubMedGoogle Scholar
  • 29 Savitha C, Satheeswaran B. A comparative study on antibacterial activity of sericin and its nanoparticles Int J Extensive Res 2015; 1: 14-17
    PubMed
  • 30 Cai Y, Jin J, Mei D. et al. Effect of silk sericin on assembly of hydroxyapatite nanocrystals into enamel prism-like structure. J Mater Chem 2009; 19: 5751-5758
    CrossrefPubMedGoogle Scholar
  • 31 Suktham K, Koobkokkruad T, Wutikhun T. et al. Efficiency of resveratrol-loaded sericin nanoparticles: Promising bionanocarriers for drug delivery. Int J Pharm 2018; 537: 48-56
    CrossrefPubMedGoogle Scholar
  • 32 Sheng Z, Hu D, Zheng M. et al. Smart human serum albumin-indocyanine green nanoparticles generated by programmed assembly for dual-modal imaging-guided cancer synergistic phototherapy. ACS Nano 2014; 8: 12310-12322
    CrossrefPubMedGoogle Scholar
  • 33 Mo Y, Barnett ME, Takemoto D. et al. Human serum albumin nanoparticles for efficient delivery of Cu, Zn superoxide dismutase gene. Molecular Vision 2007; 13: 746
    PubMedGoogle Scholar
  • 34 Yin T, Cai H, Liu J. et al. Biological evaluation of PEG modified nanosuspensions based on human serum albumin for tumor targeted delivery of paclitaxel. Eur J Pharm Sci 2016; 83: 79-87
    CrossrefPubMedGoogle Scholar
  • 35 Wang Z, Li Z, Zhang D. et al. Development of etoposide-loaded bovine serum albumin nanosuspensions for parenteral delivery. Drug Delivery 2015; 22: 79-85
    CrossrefPubMedGoogle Scholar
  • 36 Li FQ, Su H, Wang J. et al. Preparation and characterization of sodium ferulate entrapped bovine serum albumin nanoparticles for liver targeting. Int J Pharm 2008; 349: 274-282
    CrossrefPubMedGoogle Scholar
  • 37 Jahanshahi M, Najafpour G, Rahimnejad M. Applying the Taguchi method for optimized fabrication of bovine serum albumin (BSA) nanoparticles as drug delivery vehicles. African Journal of Biotechnology 2008; 7: 4
    PubMedGoogle Scholar
  • 38 Penalva R, Esparza I, Agüeros M. et al. Casein nanoparticles as carriers for the oral delivery of folic acid. Food Hydrocolloids 2015; 44: 399-406
    CrossrefPubMedGoogle Scholar
  • 39 Elzoghby AO, Samy WM, Elgindy NA. Novel spray-dried genipin-crosslinked casein nanoparticles for prolonged release of alfuzosin hydrochloride. Pharm Res 2013; 30: 512-522
    CrossrefPubMedGoogle Scholar
  • 40 Su D, Zhong Q. Formation of thymol nanoemulsions with combinations of casein hydrolysates and sucrose stearate. J Food Eng 2016; 179: 1-10
    CrossrefPubMedGoogle Scholar
  • 41 Bernela M, Ahuja M, Thakur R. Enhancement of anti-inflammatory activity of bromelain by its encapsulation in katira gum nanoparticles. Carbohydrate Polymers 2016; 143: 18-24
    CrossrefPubMedGoogle Scholar
  • 42 Bayat S, Amiri N, Pishavar E. et al. Bromelain-loaded chitosan nanofibers prepared by electrospinning method for burn wound healing in animal models. Life Sciences 2019; 229: 57-66
    CrossrefPubMedGoogle Scholar
  • 43 Caddeo C, Chessa M, Vassallo A. et al. Extraction, purification and nanoformulation of natural phycocyanin (from Klamath algae) for dermal and deeper soft tissue delivery. Journal of Biomedical Nanotechnology 2013; 9: 1929-1938
    CrossrefPubMedGoogle Scholar
  • 44 Mandal BB, Kundu SC. Self-assembled silk sericin/poloxamer nanoparticles as nanocarriers of hydrophobic and hydrophilic drugs for targeted delivery. Nanotechnology 2009; 20: 355101
    CrossrefPubMedGoogle Scholar
  • 45 Das SK, Dey T, Kundu SC. Fabrication of sericin nanoparticles for controlled gene delivery. RSC Advances 2014; 4: 2137-2142
    CrossrefPubMedGoogle Scholar