Pneumologie 2023; 77(04): 239-249
DOI: 10.1055/a-1275-5287
Fort- und Weiterbildung

Endoskopische Lungenvolumenreduktion

Bronchoscopic lung volume reduction
Jane Winantea
,
Kaid Darwiche

Die bronchoskopische Lungenvolumenreduktion ist eine sichere und wirksame Therapie für Patienten mit fortgeschrittenem Emphysem, die trotz optimaler konservativer Behandlung unter Atemnot leiden. Die Technik umfasst endobronchiale Einwegventile, thermische Dampfablation und endobronchiale Coil-Implantation. Durch die Verringerung der Hyperinflation verbessern sich Lungenfunktion, körperliche Leistungsfähigkeit und Lebensqualität. Von enormer Wichtigkeit ist das Management von Komplikationen.

Abstract

Bronchoscopic lung volume reduction is as a safe and effective therapy for patients with advanced emphysema, suffering from breathlessness despite optimal medical therapy. By reducing hyperinflation, it improves lung function, exercise capacity and quality of life. The technique includes one-way endobronchial valves, thermal vapor ablation and endobronchial coils. Patient selection is the key to a successful therapy; hence the indication should be evaluated in a multidisciplinary emphysema team meeting. The procedure can lead to a potentially life-threatening complication. Therefore, an adequate post-procedural patient management is crucial.



Publication History

Article published online:
14 April 2023

© 2023. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
  • Literatur

  • 1 Janson C, Marks G, Buist S. et al. The impact of COPD on health status: findings from the BOLD study. Eur Respir J 2013; 42: 1472-1483
  • 2 Fishman A, Martinez F, Naunheim K. et al. A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema. N Engl J Med 2003; 348: 2059-2073
  • 3 Sciurba FC, Ernst A, Herth FJ. et al. A randomized study of endobronchial valves for advanced emphysema. N Engl J Med 2010; 363: 1233-1244
  • 4 Kemp SV, Slebos DJ, Kirk A. et al. A multicenter randomized controlled trial of zephyr endobronchial valve treatment in heterogeneous emphysema (TRANSFORM). Am J Respir Crit Care Med 2017; 196: 1535-1543
  • 5 Criner GJ, Sue R, Wright S. et al. A multicenter randomized controlled trial of zephyr endobronchial valve treatment in heterogeneous emphysema (LIBERATE). Am J Respir Crit Care Med 2018; 198: 1151-1164
  • 6 Shah PL, Gompelmann D, Valipour A. et al. Thermal vapour ablation to reduce segmental volume in patients with severe emphysema: STEP-UP 12 month results. Lancet Respir Med 2016; 4: e44-e45
  • 7 Sciurba FC, Criner GJ, Strange C. et al. Effect of endobronchial coils vs usual care on exercise tolerance in patients with severe emphysema: The RENEW Randomized Clinical Trial. JAMA 2016; 315: 2178-2189
  • 8 Darwiche K, Karpf-Wissel R, Eisenmann S. et al. bronchoscopic lung volume reduction with endobronchial valves in low-FEV1 patients. Respiration 2016; 92: 414-419
  • 9 Lenga P, Ruwwe-Glosenkamp C, Grah C. et al. Endoscopic lung volume reduction with endobronchial valves in very low D LCO patients: results from the German Registry – Lungenemphysemregister e.V. ERJ Open Res 2021; 7
  • 10 van Dijk M, Hartman JE, Klooster K. et al. Endobronchial valve treatment in emphysema patients with a very low DLCO. Respiration 2020; 99: 163-170
  • 11 Davey C, Zoumot Z, Jordan S. et al. Bronchoscopic lung volume reduction with endobronchial valves for patients with heterogeneous emphysema and intact interlobar fissures (the BeLieVeR-HIFi study): a randomised controlled trial. Lancet 2015; 386: 1066-1073
  • 12 Criner GJ, Delage A, Voelker K. et al. Improving lung function in severe heterogenous emphysema with the spiration valve system (EMPROVE). A multicenter, open-label randomized controlled clinical trial. Am J Respir Crit Care Med 2019; 200: 1354-1362
  • 13 Valipour A, Slebos DJ, Herth F. et al. endobronchial valve therapy in patients with homogeneous emphysema. Results from the IMPACT Study. Am J Respir Crit Care Med 2016; 194: 1073-1082
  • 14 Ing A, Sullivan C, Hersch N. et al. Reversal of collateral ventilation using endobronchial polymer sealant in a patient with emphysema undergoing endoscopic lung volume reduction (ELVR) with valves: a case report and proof of concept. J Bronchology Interv Pulmonol 2020; 27: e14-e16
  • 15 Labarca G, Uribe JP, Pacheco C. et al. Bronchoscopic lung volume reduction with endobronchial zephyr valves for severe emphysema: a systematic review and meta-analysis. Respiration 2019; 98: 268-278
  • 16 van Dijk M, Sue R, Criner GJ. et al. Expert statement: pneumothorax associated with one-way valve therapy for emphysema: 2020 update. Respiration 2021; 100: 969-978
  • 17 Gompelmann D, Eberhardt R, Ernst A. et al. The localized inflammatory response to bronchoscopic thermal vapor ablation. Respiration 2013; 86: 324-331
  • 18 van Geffen WH, Slebos DJ, Herth FJ. et al. Surgical and endoscopic interventions that reduce lung volume for emphysema: a systemic review and meta-analysis. Lancet Respir Med 2019; 7: 313-324