Synthetic Study on Acremoxanthone A, Part 2: Model Study on the EFG Xanthone Moiety through a Nitrile Oxide Cycloaddition–S_NAr Sequence

Abstract

Toward a total synthesis of acremoxanthone A, we report a model study on the construction of the EFG ring system. The key steps include (1) an intermolecular 1,3-dipolar cycloaddition of an aryl nitrile oxide with a dienone, and (2) an S_NAr reaction for construction of the F ring.

Key words

natural products - aromatic polyketides - acremoxanthone A - isoxazoles - cycloaddition - S_NAr reaction

• References and Notes

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