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DOI: 10.1055/a-1342-7098
Serum 25-Hydroxyvitamin D Concentrations and Cardiometabolic Biomarkers in Chinese Rural Population
Funding: This work was supported by the National Nature Science Foundation of China (grants numbers 81872626 and 81573151); Chinese Nutrition Society - Bright Moon Seaweed Group Nutrition and Health Research Fund (grants numbers CNS-BMSG2020A63); Chinese Nutrition Society - Zhendong National Physical Fitness and Health Research Fund (grants numbers CNS-ZD2019066) and the Science and Technology Foundation for Innovation Talent of Henan Province (grants number 154200510010). All the funders had no role in the design, analysis or writing of this article.
Abstract
There is a paucity of data on the relation between serum 25-hydroxyvitamin D [25(OH)D] concentration and cardiometabolic biomarkers in the Chinese population. To comprehensively and quantitatively examine the association of 25(OH)D and cardiometabolic traits, we conducted a cross-sectional study in the Chinese rural population. Serum 25(OH)D and eight cardiometabolic biomarkers were measured in 1714 individuals from Henan province, China. Scatter plot was used to visualize the distribution and correlation of 25(OH)D and cardiometabolic indicators. Moreover, multivariate linear regressions and restricted cubic spline (RCS) functions were performed to examine the quantitative association between the serum 25(OH)D and cardiometabolic parameters. The median serum 25(OH)D level was 19.94 ng/ml in all participants, with an estimated 50.12% presenting vitamin D deficiency. Serum 25(OH)D level showed significantly modest association with cardiometabolic parameters (p<0.05) except for diastolic blood pressure (r=0.03, p=0.22). Multiple linear regression models showed that 25(OH)D concentration was positively associated with high-density lipoprotein cholesterol (HDL-C) and negatively associated with low-density lipoprotein cholesterol (LDL-C) and fasting serum glucose (GLU). The results of restricted cubic spline models indicated a positively linear association of 25(OH)D with HDL-C (p for overall<0.001, p for nonlinearity=0.191) and a negatively linear association with GLU (p for overall=0.024, p for nonlinearity=0.095). Overall, vitamin D deficiency was very common among Chinese rural population living near the 34 degrees north latitude. Besides, there were significant association between 25(OH)D concentrations and cardiometabolic biomarkers including HDL-C and GLU levels. Future longitudinal studies and randomized trials are warranted to clarify the causal relationship.
Publication History
Received: 19 March 2020
Accepted after revision: 17 December 2020
Article published online:
29 January 2021
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References
- 1 Holick MF. Vitamin D deficiency. N Eng J Med 2007; 357: 266-281
- 2 Faraji S, Alizadeh M. Mechanistic effects of vitamin D supplementation on metabolic syndrome components in patients with or without vitamin D deficiency. J Obes Metab Syndr 2020;
- 3 Pittas AG, Lau J, Hu FB. et al. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab 2007; 92: 2017-2029
- 4 Baeke F, Gysemans C, Korf H. et al. Vitamin D insufficiency: implications for the immune system. Pediatr Nephrol (Berlin, Germany) 2010; 25: 1597-1606
- 5 Säidifard N, Tangestani H, Djafarian K. et al. Serum vitamin D level and carotid intima-media thickness: A systematic review and meta-analysis of observational studies and randomized control trials. Horm Metab Res 2020; 52: 305-315
- 6 Skaaby T, Husemoen LL, Pisinger C. et al. Vitamin D status and changes in cardiovascular risk factors: a prospective study of a general population. Cardiology 2012; 123: 62-70
- 7 García-Bailo B, Da Costa LA, Arora P. et al. Plasma vitamin D and biomarkers of cardiometabolic disease risk in adult Canadians, 2007-2009. Prev Chronic Dis 2013; 10: E91-E91
- 8 Scragg R, Sowers M, Bell C. Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey. Diabetes Care 2004; 27: 2813-2818
- 9 Zhang X, Tu W, Manson JE. et al. Racial/Ethnic Differences in 25-Hydroxy vitamin D and parathyroid hormone levels and cardiovascular disease risk among postmenopausal women. J Am Heart Assoc 2019; 8: e011021
- 10 Yu S, Fang H, Han J. et al. The high prevalence of hypovitaminosis D in China: A multicenter vitamin D status survey. Medicine 2015; 94: e585
- 11 Zhao J, Xia W, Nie M. et al. The levels of bone turnover markers in Chinese postmenopausal women: Peking Vertebral Fracture study. Menopause (New York, NY) 2011; 18: 1237-1243
- 12 Zhen D, Liu L, Guan C. et al. High prevalence of vitamin D deficiency among middle-aged and elderly individuals in northwestern China: its relationship to osteoporosis and lifestyle factors. Bone 2015; 71: 1-6
- 13 Yang ZJ, Liu J, Ge JP. et al. Prevalence of cardiovascular disease risk factor in the Chinese population: The 2007-2008 China National Diabetes and Metabolic Disorders Study. Eur Heart J 2012; 33: 213-220
- 14 von Elm E, Altman DG, Egger M. et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: Guidelines for reporting observational studies. J Clin Epidemiol 2008; 61: 344-349
- 15 Sun H, Long SR, Li X. et al. Serum vitamin D deficiency and vitamin D receptor gene polymorphism are associated with increased risk of cardiovascular disease in a Chinese rural population. Nutr Res (New York, NY) 2019; 61: 13-21
- 16 Zhang M, Wang B, Liu Y. et al. Cumulative increased risk of incident type 2 diabetes mellitus with increasing triglyceride glucose index in normal-weight people: The Rural Chinese Cohort Study. Cardiovasc Diabetol 2017; 16: 30
- 17 Craig CL, Marshall AL, Sjostrom M. et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exercise 2003; 35: 1381-1395
- 18 Xue Y, Yang K, Wang B. et al. Reproducibility and validity of an FFQ in the Henan Rural Cohort Study. Public Health Nutr 2020; 23: 34-40
- 19 Desquilbet L, Mariotti F. Dose-response analyses using restricted cubic spline functions in public health research. Stat Med 2010; 29: 1037-1057
- 20 Bassil D, Rahme M, Hoteit M. et al. Hypovitaminosis D in the Middle East and North Africa: Prevalence, risk factors and impact on outcomes. Dermatoendocrinology 2013; 5: 274-298
- 21 Christensen MHE, Scragg RK. Consistent ethnic specific differences in diabetes risk and vitamin D status in the National Health and Nutrition Examination Surveys. J Steroid Biochem Mol Biol 2016; 164: 4-10
- 22 Lee M, Ebert JR, Kadakia MP. et al. Inverse associations between cardiometabolic risk factors and 25-hydroxyvitamin D in obese American children and adolescents. Am J Human Biol 2016; 28: 736-742
- 23 Beveridge LA, Struthers AD, Khan F. et al. Effect of vitamin D supplementation on blood pressure: A systematic review and meta-analysis incorporating individual patient data. JAMA Int Med 2015; 175: 745-754
- 24 Wood RJ. Vitamin D and adipogenesis: New molecular insights. Nutr Rev 2008; 66: 40-46
- 25 McCarty MF, Thomas CA. PTH excess may promote weight gain by impeding catecholamine-induced lipolysis-implications for the impact of calcium, vitamin D, and alcohol on body weight. Med Hypoth 2003; 61: 535-542
- 26 Wyskida M, Owczarek AJ, Chełmecka E. et al. Parathyroid hormone response to different vitamin D levels in population-based old and very-old Polish cohorts. Exp Gerontol 2019; 127: 110735
- 27 Hypponen E, Boucher BJ, Berry DJ. et al. 25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age: A cross-sectional study in the 1958 British Birth Cohort. Diabetes 2008; 57: 298-305
- 28 Hurskainen AR, Virtanen JK, Tuomainen TP. et al. Association of serum 25-hydroxyvitamin D with type 2 diabetes and markers of insulin resistance in a general older population in Finland. Diabetes/Metab Res Rev 2012; 28: 418-423
- 29 Wang T, Sun H, Ge H. et al. Association between vitamin D and risk of cardiovascular disease in Chinese rural population. PLoS One 2019; 14: e0217311
- 30 Salehpour A, Shidfar F, Hosseinpanah F. et al. Vitamin D3 and the risk of CVD in overweight and obese women: A randomised controlled trial. Br J Nutr 2012; 108: 1866-1873
- 31 Bislev LS, Langagergaard Rodbro L, Bech JN. et al. The effect of vitamin D3 supplementation on markers of cardiovascular health in hyperparathyroid, vitamin D insufficient women: A randomized placebo-controlled trial. Endocrine 2018; 62: 182-194
- 32 Kuchay MS, Laway BA, Bashir MI. et al. Effect of Vitamin D supplementation on glycemic parameters and progression of prediabetes to diabetes: A 1-year, open-label randomized study. Indian J Endocrinol Metab 2015; 19: 387-392
- 33 Skaaby T, Husemoen LL, Martinussen T. et al. Vitamin D status, filaggrin genotype, and cardiovascular risk factors: a Mendelian randomization approach. PloS one 2013; 8: e57647
- 34 Witham MD, Adams F, Kabir G. et al. Effect of short-term vitamin D supplementation on markers of vascular health in South Asian women living in the UK–a randomised controlled trial. Atherosclerosis 2013; 230: 293-299
- 35 Wamberg L, Kampmann U, Stodkilde-Jorgensen H. et al. Effects of vitamin D supplementation on body fat accumulation, inflammation, and metabolic risk factors in obese adults with low vitamin D levels - results from a randomized trial. Eur J Intern Med 2013; 24: 644-649
- 36 Williams A, Babu JR, Wadsworth DD. et al. The effects of vitamin D on metabolic profiles in women with polycystic ovary syndrome: A systematic review. Horm Metab Res 2020; 52: 485-491
- 37 Qi L, Ma W, Heianza Y. et al. Independent and synergistic associations of biomarkers of vitamin D status with risk of coronary heart disease. Arterioscler Thromb Vascul Biol 2017; 37: 2204-2212