Synlett 2021; 32(17): 1762-1766
DOI: 10.1055/a-1550-7935
letter

Ni-Catalyzed Reductive Carbonylation of Alkyl Halides to Form Dialkyl Ketones Using Diphenyl Oxalate as CO Surrogate

Yuren Sun
,
Lei Su
,
Weiqi Tong
,
Ken Yao
,
Hegui Gong

National Natural Science Foundation of China (Grant No. 21871173).


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Abstract

In this work, we disclosed that diphenyl oxalate serves as a CO surrogate to enable a Ni-catalyzed carbonylation of alkyl bromides/tosylates to afford dialkyl ketones. The reaction shows broad substrate scope and good functional group tolerance.

Supporting Information



Publication History

Received: 23 May 2021

Accepted after revision: 14 July 2021

Accepted Manuscript online:
14 July 2021

Article published online:
30 July 2021

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