Metal hydride catalyzed remote hydrofunctionalization has attracted extensive attention
in the past decade, as it provides a complementary approach for selective functionalization
of remote C(sp3)–H bonds. Recently, a wide variety of olefinic remote hydrofunctionalization reactions
have been realized through the synergistic combination of NiH-catalyzed chain-walking
and Ni-catalyzed cross-coupling. In this Account we discuss our recent achievements
in the remote hydroarylation of olefins and in asymmetric hydroarylation.
Key words
nickel catalysis - nickel hydride - chain-walking - C–H functionalization - hydroarylation
- alkene - asymmetric catalysis