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Synlett 2021; 32(20): 2063-2066
DOI: 10.1055/a-1657-5543
DOI: 10.1055/a-1657-5543
letter
Diastereoselective Pd-Catalyzed Decarboxylative Allylation To Construct Quaternary Stereocenters Using Sulfinimine as the Directing Group
This work was supported by the National Natural Science Foundation of China (NSFC, 82003186 and 82073691), the Key Research and Development Program of Tianjin City (19YFZCSY00160), the Hubei Science and Technology Program (2020CFB231), the Youth Talent Project of Health Commission of Hubei Province (ZY2021Q026), the Hubei University of Science and Technology (Doctoral Startup Fund Project BK202029).
Abstract
A robust Pd(0)-catalyzed decarboxylation alkylation has been developed to construct quaternary stereocenters through the use of chiral tert-butanesulfinamide as the directing group. This strategy provides a simple and efficient route to the construction of quaternary chiral centers at the α-position of chiral sulfinamides, with high diastereoselectivities and high yields.
Key words
diastereoselective allylic alkylation - chiral quaternary stereocenters - chiral tert-butanesulfinamides - Pd(0)-catalyzed - β-sulfinimine estersSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1657-5543.
- Supporting Information
Publication History
Received: 16 August 2021
Accepted after revision: 29 September 2021
Accepted Manuscript online:
29 September 2021
Article published online:
18 October 2021
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