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Int J Sports Med 2022; 43(06): 505-511
DOI: 10.1055/a-1670-7707
Physiology & Biochemistry

Exercise Training Increases Serum Cardiac Troponin T Independent of Left Ventricular Mass

Zhaowei Kong
1   Faculty of Education, University of Macau, Taipa, Macao
,
Haifeng Zhang
2   Physical Education College, Hebei Normal University, Shijiazhuang, China
,
Jinlei Nie 
3   School of Health Sciences and Sports, Macao Polytechnic Institute, Macao, Macao
,
Li Wen
4   Nanjing Sport Institute, Nanjing, China
,
Qingde Shi
3   School of Health Sciences and Sports, Macao Polytechnic Institute, Macao, Macao
,
San Fan Ng
3   School of Health Sciences and Sports, Macao Polytechnic Institute, Macao, Macao
,
Chuanye Huang
5   Graduate School, Shandong Sport University, Jinan, China
,
Keith George
6   Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom of Great Britain and Northern Ireland
› Author AffiliationsFunding This research was funded by Macao Polytechnic Institute (RP/ ESCSD-04/2020).
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Abstract

The purpose of this study was to determine whether exercise training mediated cardiac troponin T (cTnT) and whether this was associated with increases in left ventricular mass (LVM). Fifty-four sedentary obese women were randomised to high-intensity interval training (HIIT, repeated 4–min cycling at 90% V̇O2max interspersed with 3–min rest), work-equivalent continuous aerobic training (CAT, continuous cycling at 60% V̇O2max) or a control group (CON). Resting serum cTnT was assessed using a high-sensitivity assay before and after 12 weeks of training. LVM was determined from 2D echocardiography at the same timepoints. Both HIIT and CAT induced a similar elevation (median 3.07 to 3.76 ng.l−1, p<0.05) in resting cTnT compared with pre-training and the CON (3.49 to 3.45 ng.l−1, p>0.05). LVM index in HIIT increased (62.2±7.8 to 73.1±14.1 g.m−2, p<0.05), but not in CAT (66.1±9.7 to 67.6±9.6 g.m−2, p>0.05) and CON (67.9±9.5 to 70.2±9.1 g.m−2, p>0.05). Training-induced changes in resting cTnT did not correlate with changes in LVM index (r=−0.025, p=0.857). These findings suggest that twelve weeks of either HIIT or CAT increased resting cTnT, but the effects were independent of any changes in LVM in sedentary obese women.

Key words

cardiac biomarker - high-intensity interval training - aerobic training - cardiovascular risk factor

Supplementary Material



Publication History

Received: 11 June 2021

Accepted: 30 September 2021

Article published online:
06 December 2021

© 2021. Thieme. All rights reserved.

Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Park KC, Gaze DC, Collinson PO. et al. Cardiac troponins: from myocardial infarction to chronic disease. Cardiovasc Res 2017; 113: 1708-1718
    CrossrefPubMedSearch in Google Scholar
  • 2 Farmakis D, Mueller C, Apple FS. High-sensitivity cardiac troponin assays for cardiovascular risk stratification in the general population. Eur Heart J 2020; 41: 4050-4056
    CrossrefPubMedSearch in Google Scholar
  • 3 McEvoy JW, Chen Y, Ndumele CE. et al. Six-year change in high-sensitivity cardiac troponin t and risk of subsequent coronary heart disease, heart failure, and death. JAMA Cardiol 2016; 1: 519-528
    CrossrefPubMedSearch in Google Scholar
  • 4 Fretz A, McEvoy JW, Rebholz CM. et al. Relation of lifestyle factors and life's simple 7 score to temporal reduction in troponin levels measured by a high-sensitivity assay (from the Atherosclerosis Risk in Communities Study). Am J Cardiol 2018; 121: 430-436
    CrossrefPubMedSearch in Google Scholar
  • 5 Powers SK. Exercise: teaching myocytes new tricks. J Appl Physiol (1985) 2017; 123: 460-472
    CrossrefPubMedSearch in Google Scholar
  • 6 O’Connor CM, Ahmad T. Can we prevent heart failure with exercise?. J Am Coll Cardiol 2012; 60: 2548-2549
    CrossrefPubMedSearch in Google Scholar
  • 7 Harrington JL, Ayers C, Berry JD. et al. Sedentary behavior and subclinical cardiac injury: results from the Dallas Heart Study. Circulation 2017; 136: 1451-1453
    CrossrefPubMedSearch in Google Scholar
  • 8 Parsons TJ, Sartini C, Welsh P. et al. Objectively measured physical activity and cardiac biomarkers: a cross sectional population based study in older men. Int J Cardiol 2018; 254: 322-327
    CrossrefPubMedSearch in Google Scholar
  • 9 Legaz-Arrese A, Lopez-Laval I, George K. et al. Impact of an endurance training program on exercise-induced cardiac biomarker release. Am J Physiol Heart Circ Physiol 2015; 308: H913-H920
    CrossrefPubMedSearch in Google Scholar
  • 10 van der Linden N, Tieland M, Klinkenberg LJ. et al. The effect of a six-month resistance-type exercise training program on the course of high sensitive cardiac troponin T levels in (pre)frail elderly. Int J Cardiol 2014; 175: 374-375
    CrossrefPubMedSearch in Google Scholar
  • 11 van der Linden N, Klinkenberg LJ, Leenders M. et al. The effect of exercise training on the course of cardiac troponin T and I levels: Three independent training studies. Sci Rep 2015; 5: 18320
    CrossrefPubMedSearch in Google Scholar
  • 12 Legaz-Arrese A, Lopez-Laval I, George K. et al. Individual variability in cardiac biomarker release after 30 min of high-intensity rowing in elite and amateur athletes. Appl Physiol Nutr Metab 2015; 40: 951-958
    CrossrefPubMedSearch in Google Scholar
  • 13 Wallace TW, Abdullah SM, Drazner MH. et al. Prevalence and determinants of troponin T elevation in the general population. Circulation 2006; 113: 1958-1965
    CrossrefPubMedSearch in Google Scholar
  • 14 Xanthakis V, Larson MG, Wollert KC. et al. Association of novel biomarkers of cardiovascular stress with left ventricular hypertrophy and dysfunction: Implications for screening. J Am Heart Assoc 2013; 2: e000399
    CrossrefPubMedSearch in Google Scholar
  • 15 Lavie CJ, Ozemek C, Carbone S. et al. Sedentary behavior, exercise, and cardiovascular health. Circ Res 2019; 124: 799-815
    CrossrefPubMedSearch in Google Scholar
  • 16 Florido R, Ndumele CE, Kwak L. et al. Physical activity, obesity, and subclinical myocardial damage. JACC Heart Fail 2017; 5: 377-384
    CrossrefPubMedSearch in Google Scholar
  • 17 DeFina LF, Willis BL, Radford NB. et al. Cardiorespiratory fitness and highly sensitive cardiac troponin levels in a preventive medicine cohort. J Am Heart Assoc 2016; 5
    CrossrefPubMedSearch in Google Scholar
  • 18 Foryst-Ludwig A, Kintscher U. Sex differences in exercise-induced cardiac hypertrophy. Pflugers Arch 2013; 465: 731-737
    CrossrefPubMedSearch in Google Scholar
  • 19 Huang YC, Tsai HH, Fu TC. et al. High-intensity interval training improves left ventricular contractile function. Med Sci Sports Exerc 2019; 51: 1420-1428
    CrossrefPubMedSearch in Google Scholar
  • 20 World Health Organization. Regional Office for the Western Pacific. The Asia-Pacific perspective: Redefining Obesity and its Treatment. Sydney: Health Communications Australia;; 2000
    Search in Google Scholar
  • 21 Ainsworth BE, Macera CA, Jones DA. et al. Comparison of the 2001 BRFSS and the IPAQ Physical Activity Questionnaires. Med Sci Sports Exerc 2006; 38: 1584-1592
    CrossrefPubMedSearch in Google Scholar
  • 22 Harriss DJ, MacSween A, Atkinson G. Ethical standards in sport and exercise science research: 2020 update. Int J Sports Med 2019; 40: 813-817
    Thieme ConnectPubMedSearch in Google Scholar
  • 23 Gresslien T, Agewall S. Troponin and exercise. Int J Cardiol 2016; 221: 609-621
    CrossrefPubMedSearch in Google Scholar
  • 24 Li F, Hopkins WG, Wang X. et al. Kinetics, moderators and reference limits of exercise-induced elevation of cardiac troponin T in athletes: A systematic review and meta-analysis. Front Physiol 2021; 12: 651851
    CrossrefPubMedSearch in Google Scholar
  • 25 Nie J, Zhang H, Kong Z. et al. The impact of exercise modality and menstrual cycle phase on circulating cardiac troponin T. J Sci Med Sport 2020; 23: 309-314
    CrossrefPubMedSearch in Google Scholar
  • 26 Kyle UG, Bosaeus I, De Lorenzo AD. et al. Bioelectrical impedance analysis-part II: utilization in clinical practice. Clin Nutr 2004; 23: 1430-1453
    CrossrefPubMedSearch in Google Scholar
  • 27 Tian Y, Nie J, Huang C. et al. The kinetics of highly sensitive cardiac troponin T release after prolonged treadmill exercise in adolescent and adult athletes. J Appl Physiol (1985) 2012; 113: 418-425
    CrossrefPubMedSearch in Google Scholar
  • 28 Giannitsis E, Kurz K, Hallermayer K. et al. Analytical validation of a high-sensitivity cardiac troponin T assay. Clin Chem 2010; 56: 254-261
    CrossrefPubMedSearch in Google Scholar
  • 29 Lang RM, Badano LP, Mor-Avi V. et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr 2015; 28: 1-39 e14
    CrossrefPubMedSearch in Google Scholar
  • 30 Devereux RB, Alonso DR, Lutas EM. et al. Echocardiographic assessment of left ventricular hypertrophy: Comparison to necropsy findings. Am J Cardiol 1986; 57: 450-458
    CrossrefPubMedSearch in Google Scholar
  • 31 Ghali JK, Liao Y, Simmons B. et al. The prognostic role of left ventricular hypertrophy in patients with or without coronary artery disease. Ann Intern Med 1992; 117: 831-836
    CrossrefPubMedSearch in Google Scholar
  • 32 Palmieri V, Dahlof B, DeQuattro V. et al. Reliability of echocardiographic assessment of left ventricular structure and function. J Am Coll Cardiol 1999; 34: 1625-1632
    CrossrefPubMedSearch in Google Scholar
  • 33 Su L, Fu J, Sun S. et al. Effects of HIIT and MICT on cardiovascular risk factors in adults with overweight and/or obesity: A meta-analysis. PLoS One 2019; 14: e0210644
    CrossrefPubMedSearch in Google Scholar
  • 34 Batacan RB, Duncan MJ, Dalbo VJ. et al. Effects of high-intensity interval training on cardiometabolic health: A systematic review and meta-analysis of intervention studies. Br J Sports Med 2017; 51: 494-503
    Search in Google Scholar
  • 35 Lin X, Zhang X, Guo J. et al. Effects of exercise training on cardiorespiratory fitness and biomarkers of cardiometabolic health: A systematic review and meta-analysis of randomized controlled trials. J Am Heart Assoc 2015; 4: e002014
    CrossrefPubMedSearch in Google Scholar
  • 36 Zhang H, Tong TK, Kong Z. et al. Exercise training-induced visceral fat loss in obese women: the role of training intensity and modality. Scand J Med Sci Sports 2021; 31: 30-43
    CrossrefPubMedSearch in Google Scholar
  • 37 Kemi OJ, Haram PM, Loennechen JP. et al. Moderate vs. high exercise intensity: differential effects on aerobic fitness, cardiomyocyte contractility, and endothelial function. Cardiovasc Res 2005; 67: 161-172
    CrossrefPubMedSearch in Google Scholar
  • 38 Wisloff U, Ellingsen O, Kemi OJ. High-intensity interval training to maximize cardiac benefits of exercise training?. Exerc Sport Sci Rev 2009; 37: 139-146
    CrossrefPubMedSearch in Google Scholar
  • 39 Sanchis-Gomar F, Lippi G. Physical activity – an important preanalytical variable. Biochem Med (Zagreb) 2014; 24: 68-79
    CrossrefPubMedSearch in Google Scholar
  • 40 Daniels LB. The enemy of good?: making the most of highly sensitive troponin assays. J Am Coll Cardiol 2013; 61: 1914-1916
    CrossrefPubMedSearch in Google Scholar
  • 41 de Lemos JA, Drazner MH, Omland T. et al. Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population. Jama 2010; 304: 2503-2512
    CrossrefPubMedSearch in Google Scholar
  • 42 Ahmad T, Fiuzat M, Mark DB. et al. The effects of exercise on cardiovascular biomarkers in patients with chronic heart failure. Am Heart J 2014; 167: 193-202.e1
    CrossrefPubMedSearch in Google Scholar
  • 43 La Gerche A, Heidbuchel H, Burns AT. et al. Disproportionate exercise load and remodeling of the athlete's right ventricle. Med Sci Sports Exerc 2011; 43: 974-981
    CrossrefPubMedSearch in Google Scholar