Erfahrungsheilkunde 2022; 71(01): 12-20
DOI: 10.1055/a-1690-5713
Wissen

Aminosäuren: Einfluss auf mentales und physisches Wohlbefinden bei Freizeitsportlern

Rabea Herbst

Zusammenfassung

Eine randomisierte Doppelblindstudie mit Aminosäuren an insgesamt 38 Freizeitsportlern zeigt spannende Ergebnisse mit praktischer Relevanz im wissenschaftlichen Kontext: Entscheidend ist nicht die Menge, sondern die Qualität und Zusammensetzung der zugeführten Aminosäuren. Mit nur 8 Gramm essenziellen Aminosäuren in hydrolisierter Form konnte eine Linderung des Schmerzempfindens innerhalb von 8 Wochen Intervention erzielt werden. Damit stehen die Ergebnisse im Kontrast zu vielen Vorgängerstudien.

Abstract

A randomized double-blind study with amino acids involving a total of 38 recreational athletes shows exciting results with practical relevance in a scientific context: it is not the quantity that is decisive, but rather the quality and composition of the amino acids supplied. With only 8 grams of essential amino acids in hydrolyzed form, relief of the sensation of pain was achieved within 8 weeks of intervention. Thus, the results contrast with many previous studies.



Publication History

Article published online:
23 February 2022

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  • Literatur

  • 1 Gröber U. Mikronährstoffe. Stuttgart: Wissenschaftliche Verlagsgesellschaft; 2011. 302ff
  • 2 Waugh A, Grant A. Ross & Wilson. Anatomy and physiology in health and illness. Amsterdam: Elsevier; 2018. 11ff
  • 3 Huntington College of Health Sciences. Amino acids. Literature Education Series on Dietary Supplements. 2009
  • 4 Dato S, Hoxha E, Crocco P. et al. Amino acids and amino acid sensing: implication for aging and diseases. Biogerontology 2019; 20: 17-31
  • 5 Cynober LA. Plasma amino acid levels with a note on membrane transport: characteristics, regulation, and metabolic significance. Nutrition 2002; 18: 761-766
  • 6 Wang TJ, Larson MG, Vasan RS. et al. Metabolite profiles and the risk of developing diabetes. Nature Med 2011; 17: 448-453
  • 7 Kwakman R. Mikro- und makroskopische Betrachtung der Faszienfunktion. Dt Z Osteop 2010; 8 (02) 14-16
  • 8 Paoletti S. Faszien: Anatomie, Strukturen, Techniken, Spezielle Osteopathie. 2. Aufl.. München: Urban & Fischer; 2011. 117ff
  • 9 Lodish H, Berk A, Zipursky SL. Molecular cell biology. 4. Aufl.. New York: W. H. Freeman; 2000
  • 10 Schleip R, Findley TW. Fascia research. Basic science and implications for conventional and complementary health care. München: Kiener; 2015
  • 11 Nurmikko T, Pertovaara A, Pontinen PJ. Attenuation of tourniquet-induced pain in man by D-phenylalanine, a putative inhibitor of enkephalin degradation. Acupunct Electr-Ther Res 1987; 12: 185-191
  • 12 Christianson DW, Mangani S, Shoham G. et. al. Binding of D-phenylalanine and D-tyrosine to carboxypeptidase A. J Biol Chem 1989; 264 (22) 12849-12853
  • 13 Benito-Ruiz P, Camacho-Zambrano MM, Carrillo-Arcentales JN. et al. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. Int J Food Sci Nutr 2009; 1-15
  • 14 Bruyère O, Zegels B, Leonori L. et al. Effect of collagen hydrolysate in articular pain: A 6-month randomized, double-blind, placebo controlled study. Compl Ther Medic 2012; 20: 124-130
  • 15 Lugo JP, Saiyed ZM, Lane NE. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: A multicenter randomized, double-blind, placebo-controlled study. Nutr J 2016; 15: 1-15
  • 16 Shell WE, Charuvastra EH, DeWood MA. et al. A double-blind controlled trial of a single dose naproxen and an amino acid medical food theramine for the treatment of low back pain. Am J Therap 2012; 19: 108-114
  • 17 Brain K, Burrows TL, Rollo ME. et al. A systematic review and meta-analysis of nutrition interventions for chronic noncancer pain. J Human Nutr Diet 2018; 1-28
  • 18 Wienecke E. Meilensteine in der Regulationsmedizin: Individualisierte Mikronährstoffrezepturen. Case-Reports von 144 Profis. Sportaerzte Z. 2019 19. (2)
  • 19 Cowen PJ, Parry-Billings M, Newsholme EA. Decreased plasma tryptophan levels in major depression. J Aff Dis 1989; 16: 27-31
  • 20 Green AR, Aronson JK, Curzon G. et al. Metabolism of an oral tryptophan load: Effects of dose and pretreatment with tryptophan. Br J Clin Pharmacol 1980; 10 (06) 603-610
  • 21 Benedict CR, Anderson GH, Sole MJ. The influence of oral tyrosine and tryptophan feeding on plasma catecholamines in man. Am J Clin Nutr 1983; 38 (03) 429-435
  • 22 Richard DM, Dawes MA, Mathias CW. et al. L-Tryptophan: Basic metabolic functions, behavioral research and therapeutic indications. Int J Tryptoph Res 2009; 2: 45-60
  • 23 Baranyi A, Amouzadeh-Ghadikolai O, von Lewinski D. et al. Branched-chain amino acids as new biomarkers of major depression – a novel neurobiology of mood disorder. PLoS ONE 2016; 11 (08) 1-10
  • 24 Wienecke E. Mikronährstoffe – Meilensteine der Gesundheitsmedizin. Aachen: Meyer & Meyer; 2021. 110ff
  • 25 Schröcksnadel K, Wirleitner B, Winkler C. et al. Monitoring tryptophan metabolism in chronic immune activation. Clin Chim Acta 2005; 364: 82-90
  • 26 Miura H, Ozaki N, Sawada M. et al. A link between stress and depression: Shifts in the balance between the kynurenine and serotonin pathways of tryptophan metabolism and the etiology and pathophysiology of depression. Stress 2008; 11: 198-209
  • 27 Croft P, Blyth FM, van der Windt D. Chronic pain epidemiology. From aetiology to public health. Oxford: Oxford University Press; 2010
  • 28 Labunskyy VM, Hatfield DL, Gladyshev VN. Selenoproteins: molecular pathways and physiological roles. Physiol Rev 2014; 94 (03) 739-777