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Zeitschrift für Phytotherapie 2022; 43(01): 21-23
DOI: 10.1055/a-1746-1551
Peer Review

Zur antiviralen Wirkung von Zubereitungen aus dem Knoblauch

Studies on the Antiviral Effect of Preparations from Garlic
Julia Vlachojannis
1   Institut für Rechtsmedizin, Universität Freiburg
,
Sigrun Chrubasik-Hausmann
1   Institut für Rechtsmedizin, Universität Freiburg
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Zusammenfassung

An der antiviralen Wirkung von Knoblauch mit seinen organischen Schwefelverbindungen und Lektinen muss nicht gezweifelt werden. Die viruzide Wirkung wurde experimentell für unbehüllte und behüllte, Pandemien auslösende Viren demonstriert. Am antiviralen Wirkungsmechanismus sind eine Interaktion mit den Rezeptoren der Zielzelle, eine Hemmung der Enzyme, die das Eindringen in die Zielzelle ermöglichen, eine Hemmung der Replikation und Ausscheidung der Virionen beteiligt. Sieben exploratorische Studien weisen auf eine potente antivirale Wirksamkeit. Konfirmatorische Studien müssen jetzt für jede Knoblauch-Zubereitung die optimale Dosis und die Wirkgröße zur Prävention und Therapie viraler Infektionen evaluieren.

Abstract

The antiviral effect of garlic and its organosulfur and lectin compounds is beyond any doubt. In vitro experiments demonstrate the virucidal effect on viruses without envelopes or with envelopes. The latter are the ones causing pandemics. The antiviral mechanism of action include various targets, e. g. receptor interaction, inhibition of enzymes that enable penetration into cells, inhibition of replication and excretion of virions. Seven exploratory studies indicate a potent antiviral effectiveness in humans. Confirmatory studies must now evaluate the effect size for every garlic preparation after dose-finding studies have established the optimum daily dosage for the prevention and treatment of viral infections.

Schlüsselwörter

Knoblauch - organische Schwefelverbindungen - antivirale Wirkung - SARS-CoV-2

Key words

Garlic - organic sulphur compounds - antiviral effect - SARS-CoV-2


Publication History

Received: 13 January 2022

Accepted: 10 February 2022

Article published online:
15 March 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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