A new and simple method for preparing 2-arylindole derivatives under transition-metal-free
conditions has been developed. When N-(2-methyl-3-nitrophenyl)acetamide was treated with 2-fluorobenzaldehydes in the presence
of Cs2CO3 in DMF at 60 °C, the desired indoles were typically obtained in moderate to good
yields (up to 83%). When other aniline substrates were employed, only a Knoevenagel
condensation occurred, giving the corresponding diarylethenes in moderate to excellent
yields.
Key words
indoles - one-pot synthesis - transition-metal-free synthesis - cascade reaction -
Knoevenagel condensation