Complete closure of mucosal defect after colonic endoscopic submucosal dissection using clip with a silicone traction band

Endoscopic submucosal dissection (ESD) is a standard treatment for colorectal neoplasms, but the risk of severe postoperative complications persists even after successful ESD [1] [2]. Therefore, complete closure of defects after ESD is essential to prevent such complications [3]. Although complete closure is a technically difficult procedure, several techniques have been developed to assist [4] [5]. Herein, we present a case of successful complete closure of a mucosal defect after colonic ESD using clips with a silicone traction band ([Fig. 1]).

Fig. 1 The clip with a silicone traction band (arrow).

ESD was performed to resect a 35-mm laterally spreading tumor located in the ascending colon; however, a 50-mm mucosal defect remained after lesion retrieval. Pulsating vessels and minor muscular injuries were observed in this defect. Endoscopic closure using clips with a silicone traction band was performed on the lesion ([Video 1]).

Video 1 Complete closure of a mucosal defect using clips with a silicone traction band after colonic endoscopic submucosal dissection.

The first clip with a band was placed at the proximal edge of the mucosal defect ([Fig. 2 a]). The second clip was placed at the distal opposite edge, and it hooked the silicone traction band attached to the base of the first clip ([Fig. 2 b, c]). Bridging the bilateral mucosal edges changed the shape from large oval to a figure of eight ([Fig. 2 d]). Subsequently, complete closure of the mucosal defect was achieved by placing conventional clips on both sides ([Fig. 2 e, f]). No complications occurred following the procedure.

Fig. 2 Schemata showing key steps of the endoscopic closure using clips with a silicone traction band. a The first clip with a silicone traction band was placed at the proximal margin of the mucosal defect after colonic endoscopic submucosal dissection. b The second clip hooked the silicone traction band attached to the base of the first clip. c The second clip was placed at the distal opposite margin of the mucosal defect. d Bridging the bilateral mucosal edges using clips with a silicone traction band changed the oval shape of the mucosal defect to a figure-of-eight shape. e Conventional clips were placed at the left side of the figure of eight. f Conventional clips were also placed on the right side of the figure of eight. Complete closure of the mucosal defect was then achieved.

The elastic energy of the silicone traction band attached to the base of the clip was sufficiently large to generate an appropriate traction force between the two clips. The advantage of this clip is that it is easily available and does not require preparation of any complicated device. Second, it is repositionable until the clips are placed at the right site. This method can be a good option for complete endoscopic closure of mucosal defects after colorectal ESD.

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Competing interests

Eikichi Ihara participated in funded research for Takeda Pharmaceutical Co., Ltd. and belongs to the endowed course supported by the companies mentioned, including Ono Pharmaceutical Co., Ltd., Miyarisan Pharmaceutical Co. Ltd., Sanwa Kagaku Kenkyusho Co., Ltd., Otsuka Pharmaceutical Factory, Inc., Fujifilm Medical Co., Ltd., Termo Corporation, FANCL Corporation, and Ohga Pharmacy. Eikichi Ihara also received a lecture fee from Takeda Pharmaceutical Co. The remaining authors declare that they have no conflict of interest.

• References

• 1 Santos JB, Nobre MRC, Oliveira CZ. et al. Risk factors for adverse events of colorectal endoscopic submucosal dissection: a systematic review and meta-analysis. Eur J Gastroenterol Hepatol 2021; 33: e33-e41
• 2 Arezzo A, Passera R, Marchese N. et al. Systematic review and meta-analysis of endoscopic submucosal dissection vs endoscopic mucosal resection for colorectal lesions. United European Gastroenterol J 2016; 4: 18-29
• 3 Liu M, Zhang Y, Wang Y. et al. Effect of prophylactic closure on adverse events after colorectal endoscopic submucosal dissection: a meta-analysis. J Gastroenterol Hepatol 2020; 35: 1869-1877
• 4 Ogiyama H, Tsutsui S, Murayama Y. et al. Prophylactic clip closure may reduce the risk of delayed bleeding after colorectal endoscopic submucosal dissection. Endosc Int Open 2018; 6: E582-E588
• 5 Minoda Y, Ihara E, Ogino H. et al. The efficacy and safety of a promising single-channel endoscopic closure technique for endoscopic treatment-related artificial ulcers: a pilot study. Gastrointest Tumors 2020; 7: 21-29

Publication History

Article published online:
04 August 2022