Hypercholesterinämie und kardiovaskuläres Risiko

Für die Prävention kardiovaskulärer Ereignisse stellt die Reduktion des LDL-Cholesterins (LDL-C) eine entscheidende Maßnahme dar. Zwar bleiben Statine das Mittel der ersten Wahl, jedoch stehen mit Ezetimib, Bempedoinsäure und der PCSK9-Inhibition weitere LDL-C-senkende Wirkstoffe zur Verfügung. Diese sollten zur LDL-C-Zielwerterreichung und somit zur kardiovaskulären Risikoreduktion insbesondere bei Hochrisikopatienten frühzeitig zum Einsatz kommen.

Abstract

Pharmacological reduction of LDL-cholesterol (LDL-C) is a major treatment strategy in limiting atherosclerotic cardiovascular (ASCVD) risk. Statins remain the primary therapeutic cornerstone in ASCVD prevention. Furthermore, ezetimibe, bempedoic acid, and PCSK9 inhibition have recently also shown to reduce cardiovascular risk. Unfortunately, a treatment gap remains between guideline-recommended LDL-C goals and what is achieved in real-world practice. An important reason for this is the limited use of novel and effective non-statin lipid-lowering therapies. In order to achieve LDL-C treatment goals and, ultimately, reduction of cardiovascular events, a combination lipid-lowering therapy needs to be considered as the standard of care for patients at very high cardiovascular risk.

Schlüsselwörter

Hypercholesterinämie - kardiovaskulär - Risiko - LDL-Cholesterin

Keywords

hypercholesterolemia - cardiovascular - risk - LDL-cholesterol

Publikationsverlauf

Artikel online veröffentlicht:
04. August 2023

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