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Z Geburtshilfe Neonatol 2023; 227(01): 24-30
DOI: 10.1055/a-1956-3927
Review

Probiotic Supplement for the Prevention of Gestational Diabetes: A Meta-Analysis of Randomized Controlled Trials

Xuexia Chen‡
1   Nursing School of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China
,
Linlin Pan‡
2   Department of Traumatology of the Second Affiliated Hospital of Innmer Mongolia Medical University, Hohhot, Inner Mongolia, China
,
Zengliang Zhang
3   Traditinal Chinese Medicine College, Inner Mongolia Medical University, Jinshan Economic & Technology Development Zone, Hohhot, Inner Mongolia, China
,
Renxiu Niu
3   Traditinal Chinese Medicine College, Inner Mongolia Medical University, Jinshan Economic & Technology Development Zone, Hohhot, Inner Mongolia, China
,
Huixin Zhang
1   Nursing School of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China
,
Teng Ma
1   Nursing School of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China
› Author Affiliations Funding The General Program of Inner Mongolia Medical University
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Abstract

Background Probiotic supplements may have some potential in preventing gestational diabetes, and this meta-analysis aims to explore the efficacy of probiotic supplements to prevent gestational diabetes.

Methods PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systematically searched, and we included randomized controlled trials (RCTs) assessing the effect of probiotic supplements on the incidence of gestational diabetes mellitus. Meta-analysis was performed using the fixed-effect or random-effect model as appropriate.

Results Six RCTs were finally included in the meta-analysis. Overall, compared with control intervention in pregnant women, probiotic supplementation intervention showed no obvious impact on the incidence of gestational diabetes (OR=0.68; 95% CI=0.39 to 1.20; P=0.18), fasting plasma glucose (SMD=−0.05; 95% CI=−0.29 to 0.19; P=0.69), 2 h-OGTT (SMD=−0.07; 95% CI=−0.27 to 0.13; P=0.47), gestational age (SMD=0.04; 95% CI=−0.14 to 0.21; P=0.69) or preeclampsia (OR=1.22; 95% CI=0.83 to 1.78; P=0.31).

Conclusions Probiotic supplementation was confirmed to have no benefits for the prevention of gestational diabetes.

Key words

probiotic supplement - gestational diabetes - prevention


Publication History

Received: 19 May 2022

Accepted after revision: 23 September 2022

Article published online:
11 November 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

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