Relationship between Euthyroidism and Muscle Mass and Strength: A Systematic Review

Abstract

Thyroid hormones play a crucial role in skeletal muscle development, suggesting that thyroid function may influence muscle mass and muscle strength, which are both fundamental health-related indicators of several age-related consequences. However, whether there is a relationship between thyroid hormones, muscle mass, and muscle strength in individuals without thyroid dysfunctions is still unknown. Therefore, this systematic review aims to investigate whether thyroid hormones are related to muscle mass and strength parameters in euthyroid individuals. Three databases were searched (PubMed, Scopus, Web of Science) up to February 14, 2022, for peer-reviewed papers published in English. The search results were conducted independently by two different reviewers. The review included 13 studies with a total of 241,044 participants. All studies were observational: twelve studies measured thyroid stimulating hormone, ten and thirteen studies measured free triiodothyronine and free thyroxine, four studies analyzed the thyroid hormone ratio. The assessment methods for muscle mass were computed tomography, dual-energy X-ray absorptiometry and bioimpedance analysis, whereas hand dynamometer for muscle strength. Low levels within the normal range of free triiodothyronine, high levels within the normal range of free thyroxine, and lower thyroid hormone ratio may contribute to a reduced muscle function, which seems more evident in older males.

Key words

exercise - skeletal muscle - aging, - thyroid - health - exercise - endocrinology - health - sport - doping - skeletal muscle - ageing - bone mineral density - physical exercise

Publikationsverlauf

Eingereicht: 13. September 2022

Angenommen: 26. April 2023

Artikel online veröffentlicht:
10. Juli 2023

• References

• 1 Frontera WR, Ochala J. Skeletal muscle: a brief review of structure and function. Calcif Tissue Int 2015; 96: 183-195
• 2 McLeod M, Breen L, Hamilton DL. et al. Live strong and prosper: the importance of skeletal muscle strength for healthy ageing. Biogerontology 2016; 17: 497-510
• 3 Cruz-Jentoft AJ, Bahat G, Bauer J. et al. Sarcopenia: Revised European consensus on definition and diagnosis [published correction appears in Age Ageing. 2019; 48: 601]. Age Ageing 2019; 48: 16-31
• 4 Dodds R, Sayer AA. Sarcopenia and frailty: New challenges for clinical practice. Clin Med (Lond) 2016; 16: 455-458
• 5 Salvatore D, Simonides WS, Dentice M. et al. Thyroid hormones and skeletal muscle: New insights and potential implications. Nat Rev Endocrinol 2014; 10: 206-214
• 6 Bloise FF, Cordeiro A, Ortiga-Carvalho TM. Role of thyroid hormone in skeletal muscle physiology. J Endocrinol 2018; 236: R57-R68
• 7 Maggio M, Lauretani F, De Vita F. et al. Multiple hormonal dysregulation as determinant of low physical performance and mobility in older persons. Curr Pharm Des 2014; 20: 3119-3148
• 8 van den Beld AW, Kaufman JM, Zillikens MC. et al. The physiology of endocrine systems with ageing. Lancet Diabetes Endocrinol 2018; 6: 647-658
• 9 Garmendia Madariaga A, Santos Palacios S, Guillén-Grima F. et al. The incidence and prevalence of thyroid dysfunction in Europe: A meta-analysis. J Clin Endocrinol Metab 2014; 99: 923-931
• 10 Biondi B, Bartalena L, Cooper DS. et al. The 2015 european thyroid association guidelines on diagnosis and treatment of endogenous subclinical hyperthyroidism. Eur Thyroid J 2015; 4: 149-163
• 11 Brennan MD, Powell C, Kaufman KR. et al. The impact of overt and subclinical hyperthyroidism on skeletal muscle. Thyroid 2006; 16: 375-380
• 12 Virgini VS, Rodondi N, Cawthon PM. et al. Subclinical thyroid dysfunction and frailty among older men. J Clin Endocrinol Metab 2015; 100: 4524-4532
• 13 Bertoli A, Valentini A, Cianfarani MA. et al. Low FT3: A possible marker of frailty in the elderly. Clin Interv Aging 2017; 12: 335-341
• 14 Ceresini G, Ceda GP, Lauretani F. et al. Mild thyroid hormone excess is associated with a decreased physical function in elderly men. Aging Male 2011; 14: 213-219
• 15 van den Beld AW, Visser TJ, Feelders RA. et al. Thyroid hormone concentrations, disease, physical function, and mortality in elderly men. J Clin Endocrinol Metab 2005; 90: 6403-6409
• 16 Lambrinoudaki I, Armeni E, Rizos D. et al. Indices of adiposity and thyroid hormones in euthyroid postmenopausal women. Eur J Endocrinol 2015; 173: 237-245
• 17 Demir Ş, Kara Y, Melikoğlu M. et al. New anthropometric measurements: relationship to thyroid functions in euthyroid obese subjects. Cureus 2021; 13: e20435
• 18 Ren R, Jiang X, Zhang X. et al. Association between thyroid hormones and body fat in euthyroid subjects. Clin Endocrinol (Oxf) 2014; 80: 585-590
• 19 Casas F, Pessemesse L, Grandemange S. et al. Overexpression of the mitochondrial T3 receptor induces skeletal muscle atrophy during aging. PLoS One 2009; 4: e5631
• 20 Page MJ, McKenzie JE, Bossuyt PM. et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ 2021; 372: n71
• 21 Ahn SH, Seo DH, Cho Y. et al. Different relationships between thyrotropin and muscle strength according to sex and age in euthyroid koreans (The 6th korea national health and nutritional examination survey 2014–2015). Thyroid 2020; 30: 1710-1717
• 22 Kim BJ, Lee SH, Isales CM. et al. Association of serum tsh with handgrip strength in community-dwelling euthyroid elderly. J Clin Endocrinol Metab 2018; 103: 3986-3992
• 23 Kong SH, Kim JH, Park YJ. et al. Low free T3 to free T4 ratio was associated with low muscle mass and impaired physical performance in community-dwelling aged population. Osteoporos Int 2020; 31: 525-531
• 24 Kwon H, Cho JH, Lee DY. et al. Association between thyroid hormone levels, body composition and insulin resistance in euthyroid subjects with normal thyroid ultrasound: The Kangbuk Samsung Health Study. Clin Endocrinol (Oxf) 2018; 89: 649-655
• 25 Lee J, Jo K, Ha J. et al. A significant association of upper limb muscle strength with thyroid function in overweight and obese population: a study of the sixth korea national health and nutrition examination survey (KNHANES 2014–2015). Int J Endocrinol 2020; 2020: 7195846
• 26 Park YS, Chang Y, Lee YT. et al. The prospective relationship between low muscle mass and thyroid hormones among 198 069 euthyroid men and women; comparing different definitions of low muscle mass. Int J Clin Pract 2021; 75: e13710
• 27 Chen L, Zhang M, Xiang S. et al. Association between thyroid function and body composition in type 2 diabetes mellitus (t2dm) patients: does sex have a role?. Med Sci Monit 2021; 27: e927440
• 28 Gu Y, Meng G, Wu H. et al. Thyroid function as a predictor of handgrip strength among middle-aged and older euthyroid adults: The tclsih cohort study. J Am Med Dir Assoc 2019; 20: 1236-1241
• 29 Sheng Y, Ma D, Zhou Q. et al. Association of thyroid function with sarcopenia in elderly Chinese euthyroid subjects. Aging Clin Exp Res 2019; 31: 1113-1120
• 30 Xiu S, Mu Z, Zhao L. et al. Low free triiodothyronine levels are associated with risk of frailty in older adults with type 2 diabetes mellitus. Exp Gerontol 2020; 138: 111013
• 31 Emerenziani GP, Izzo G, Vaccaro MG. et al. Gender difference and correlation between sexuality, thyroid hormones, cognitive, and physical functions in elderly fit. J Endocrinol Invest 2019; 42: 699-707
• 32 Zupo R, Castellana F, Sardone R. et al. Higher muscle mass implies increased free-thyroxine to free-triiodothyronine ratio in subjects with overweight and obesity. Front Endocrinol (Lausanne) 2020; 11: 565065
• 33 Roef G, Lapauw B, Goemaere S. et al. Body composition and metabolic parameters are associated with variation in thyroid hormone levels among euthyroid young men. Eur J Endocrinol 2012; 167: 719-726
• 34 Priego T, Martín AI, González-Hedström D. et al. Role of hormones in sarcopenia. Vitam Horm 2021; 115: 535-570
• 35 Ramsay ID. Muscle dysfunction in hyperthyroidism. Lancet. 1966; 2: 931-934
• 36 Duyff RF, Van den Bosch J, Laman DM. et al. Neuromuscular findings in thyroid dysfunction: a prospective clinical and electrodiagnostic study. J Neurol Neurosurg Psychiatry 2000; 68: 750-755
• 37 Haizlip KM, Harrison BC, Leinwand LA. Sex-based differences in skeletal muscle kinetics and fiber-type composition. Physiology (Bethesda) 2015; 30: 30-39
• 38 Tieland M, Trouwborst I, Clark BC. Skeletal muscle performance and ageing. J Cachexia Sarcopenia Muscle 2018; 9: 3-19
• 39 Babić Leko M, Gunjača I, Pleić N. et al. Environmental factors affecting thyroid-stimulating hormone and thyroid hormone levels. Int J Mol Sci 2021; 22: 6521
• 40 Hackney AC, Saeidi A. The thyroid axis, prolactin, and exercise in humans. Curr Opin Endocr Metab Res 2019; 9: 45-50
• 41 Klasson CL, Sadhir S, Pontzer H. Daily physical activity is negatively associated with thyroid hormone levels, inflammation, and immune system markers among men and women in the NHANES dataset. PLoS One 2022; 17: e0270221
• 42 Leal LG, Lopes MA, Batista ML. Physical exercise-induced myokines and muscle-adipose tissue crosstalk: A review of current knowledge and the implications for health and metabolic diseases. Front Physiol 2018; 9: 1307
• 43 Distefano G, Goodpaster BH. Effects of exercise and aging on skeletal muscle. Cold Spring Harb Perspect Med 2018; 8: a029785
• 44 Hackney AC, Viru A. Research methodology: endocrinologic measurements in exercise science and sports medicine. J Athl Train 2008; 43: 631-639