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Synlett 2024; 35(05): 500-512
DOI: 10.1055/a-2103-9823
DOI: 10.1055/a-2103-9823
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Direct Fluoroalkylthiolation Based on Fluoroalkanesulfite Derivatives
The authors thank the National Natural Science Foundation of China (22078161, 22108124, 52103217), the Fundamental Research Funds for the Central Universities (30920021124, 30918011314, 30921011205), the High-Level Personnel Project of Jiangsu Province (JSSCBS20210227), the Postdoctoral Science Foundation Funded Project (2019M661848), the Priority Academic Program Development of Jiangsu Higher Education Institutions, the second level of the ‘333 Project’ of Jiangsu Province (High Level Talent Training Project) and the Center for Advanced Materials and Technology at Nanjing University of Science and Technology for their financial support.
Abstract
Fluoroalkylthio groups have received substantial attention in the past decade because of their unique physicochemical characteristics, and methods for incorporating these substituents into organic molecules have been rapidly developed in recent years. This account summarizes our efforts on the development of direct fluoroalkylthiolation with fluoroalkanesulfite derivatives. Several innovative and efficient strategies for the fluoroalkylthiolation of various substrates are disclosed, leading to various valuable fluoroalkylthiolated compounds in good yields.
1 Introduction
2 Fluoroalkylthiolation with Sodium Fluoroalkanesulfinate
3 Fluoroalkylthiolation with Fluoroalkanesulfonyl Chloride
4 Fluoroalkylthiolation with Other Fluoroalkanesulfite Derivatives
5 Conclusion
Key words
trifluoromethylthiolation - difluoromethylthiolation - organofluorine compounds - sodium trifluoromethylsulfinate - trifluoromethylsulfonyl chloridePublication History
Received: 15 May 2023
Accepted after revision: 31 May 2023
Accepted Manuscript online:
31 May 2023
Article published online:
17 July 2023
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