Thyroid-Related Hormones Changes Predict Changes in Anthropometric
                    Measures and Incidence of Obesity in Chinese Euthyroid Persons

Ling Deng; Xiaoxia Zheng; Ping Shuai; Xijie Yu

doi:10.1055/a-2151-1538

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 2023; 55(10): 684-691
DOI: 10.1055/a-2151-1538

Original Article: Endocrine Care

Thyroid-Related Hormones Changes Predict Changes in Anthropometric Measures and Incidence of Obesity in Chinese Euthyroid Persons

Ling Deng

¹Laboratory of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China

²Department of Health Management & Institute of Health Management, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China

,

Xiaoxia Zheng

²Department of Health Management & Institute of Health Management, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China

,

Ping Shuai

²Department of Health Management & Institute of Health Management, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China

,

Xijie Yu

¹Laboratory of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China

› Institutsangaben

Abstract

The purpose of this study was to investigate the correlation of thyroid-related hormones changes within the reference range with the changes in anthropometric measures and incidence of obesity. The study included 4850 subjects with normal thyroid-related hormones at baseline and at follow-up. We evaluated the relationship of changes in thyroid-related biomarkers with anthropometric measures changes and incidence of obesity. In euthyroid persons, changes in serum thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) concentrations and FT3/FT4 ratio were independent predictors of changes in body mass index (BMI) and waist circumference (WC) in men, changes in serum FT3 and FT4 concentrations and FT3/FT4 ratio were independent predictors of changes in BMI and WC in women. Every single unit increment in ΔFT3/FT4 was accompanied by a 7.144 and 7.572 times risk of having obesity in men and women, respectively. Every single unit decrement in ΔFT4 was accompanied by a 21.0% and 26.9% lower risk of having obesity in men and women, respectively. In conclusion, in euthyroid individuals, changes in thyroid-related hormones were associated with anthropometric measures changes and incidence of obesity.

Key words

thyroid-related hormone - anthropometric measure - obesity - euthyroid person

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