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Thorac Cardiovasc Surg
DOI: 10.1055/a-2263-1933
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Impact of Age on the Relationship between Cross-Clamp Time and Mortality in Cardiac Surgery

Murat Mukharyamov
1   Department of Cardiothoracic Surgery, Jena University Hospital, Friedrich Schiller University of Jena, Jena, Germany
,
Hristo Kirov
1   Department of Cardiothoracic Surgery, Jena University Hospital, Friedrich Schiller University of Jena, Jena, Germany
,
Tulio Caldonazo
1   Department of Cardiothoracic Surgery, Jena University Hospital, Friedrich Schiller University of Jena, Jena, Germany
,
Torsten Doenst
1   Department of Cardiothoracic Surgery, Jena University Hospital, Friedrich Schiller University of Jena, Jena, Germany
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Abstract

Age is an independent risk factor for mortality even when all known comorbidities are considered. Thus, other factors may additionally contribute to the age-associated risk. We performed a systematic literature search and identified 161 manuscripts, of which 32 studies (18,256 patients) were analyzed. Cross-clamp time correlated with observed mortality. The increase in mortality risk with cross-clamp time was much greater in older patients than in younger patients. The log odds ratio (OR) for age and cross-clamp time was 0.07 and 0.01, respectively, which was highly significant for both independent risk factors. Age accelerates the increase in mortality risk with increasing aortic cross-clamp times.

Keywords

myocardial protection/cardioplegia (including metabolism) - outcomes (includes mortality - morbidity) - cardiopulmonary bypass


Publication History

Received: 08 November 2023

Accepted: 04 February 2024

Accepted Manuscript online:
07 February 2024

Article published online:
16 April 2024

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