CGRP: vom Neuropeptid zum therapeutischen Target (Hintergründe und Pathophysiologie)

Zusammenfassung

Calcitonin Gene-related Peptide (CGRP) spielt eine zentrale Rolle in der Pathophysiologie der Migräne. Die Bedeutung von CGRP für die Migräne ist aus zahlreichen klinischen Studien mit Nachweis von erhöhten CGRP-Spiegeln iktal und interiktal sowie der Wirksamkeit der CGRP-basierten Therapien bekannt. In der vorliegenden Arbeit werden diese Studien vorgestellt und so der Weg zur Entwicklung der CGRP-basierten Medikamente aufgezeigt. Abschließend werden aktuelle Studienergebnisse in Bezug auf die CGRP-Rezeptorantagonisten, die sogenannten Gepante, vorgestellt.

Abstract

Calcitonin gene-related peptide (CGRP) plays a pivotal role in migraine pathophysiology. The importance of CGRP in migraine became evident from numerous clinical studies investigating CGRP levels both interictally and ictally and reports on the efficacy of CGRP-based migraine therapies. In this paper, the above mentioned studies will be presented and the reader will be introduced to the development of CGRP-based medication. Finally, current study results on CGRP receptor antagonists, the so-called gepants, will be presented.

Schlüsselwörter

Migräne - Kopfschmerz - Calcitonin Gene-related Peptid - CGRP-Rezeptorantagonisten

Keywords

migraine - headache - CGRP receptor antagonists - Calcitonin gene-related peptide

Publication History

Received: 13 November 2023

Accepted after revision: 15 May 2024

Article published online:
18 July 2024

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