Dihydromyricetin Improves High Glucose-Induced Dopaminergic Neuronal
                    Damage by Activating AMPK-Autophagy Signaling Pathway

Qi Li; Zhenjiang Song; Liting Peng; Shuidong Feng; Kebin Zhan; Hongyan Ling

doi:10.1055/a-2399-1174

Experimental and Clinical Endocrinology & Diabetes, Inhaltsverzeichnis

Exp Clin Endocrinol Diabetes 2024; 132(11): 631-641
DOI: 10.1055/a-2399-1174

Article

Dihydromyricetin Improves High Glucose-Induced Dopaminergic Neuronal Damage by Activating AMPK-Autophagy Signaling Pathway

Qi Li‡

¹Department of Physiology, University of South China Hengyang Medical School, Hengyang, China (Ringgold ID: RIN159373)

²Department of Pathology, Yuebei People’s Hospital Affiliated to Shantou University School of Medicine, Shaoguan, China (Ringgold ID: RIN159372)

,

Zhenjiang Song‡

¹Department of Physiology, University of South China Hengyang Medical School, Hengyang, China (Ringgold ID: RIN159373)

,

Liting Peng

¹Department of Physiology, University of South China Hengyang Medical School, Hengyang, China (Ringgold ID: RIN159373)

,

Shuidong Feng

³Department of Social Medicine and Health Management, University of South China Hengyang Medical School, Hengyang, China (Ringgold ID: RIN159373)

,

Kebin Zhan

⁴Department of Neurology, The Second Affiliated Hospital, University of South China Hengyang Medical School, Hengyang, China (Ringgold ID: RIN159373)

,

Hongyan Ling

¹Department of Physiology, University of South China Hengyang Medical School, Hengyang, China (Ringgold ID: RIN159373)

› Institutsangaben

Abstract

Introduction In recent years, a growing number of clinical and biological studies have shown that patients with type 2 diabetes mellitus (T2DM) are at increased risk of developing Parkinson’s disease (PD). Prolonged exposure to hyperglycemia results in abnormal glucose metabolism, which in turn causes pathological changes similar to PD, leading to selective loss of dopaminergic neurons in the compact part of the substantia nigra. Dihydromyricetin (DHM) is a naturally occurring flavonoid with various biological activities including antioxidant and hepatoprotective properties. In this study, the effect of DHM on high glucose-induced dopaminergic neuronal damage was investigated.

Methods The potential modulatory effects of DHM on high glucose-induced dopaminergic neuronal damage and its mechanism were studied.

Results DHM ameliorated high glucose-induced dopaminergic neuronal damage and autophagy injury. Inhibition of autophagy by 3-methyladenine abrogated the beneficial effects of DHM on high glucose-induced dopaminergic neuronal damage. In addition, DHM increased levels of p-AMP-activated protein kinase (AMPK) and phosphorylated UNC51-like kinase 1. The AMPK inhibitor compound C eliminated DHM-induced autophagy and subsequently inhibited the ameliorative effects of DHM on high glucose-induced dopaminergic neuronal damage.

Discussion DHM ameliorates high glucose-induced dopaminergic neuronal damage by activating the AMPK-autophagy pathway.

Keywords

dihydromyricetin - AMPK - autophagy - dopaminergic neuronal - high glucose

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