A new treatment for endoscopic ultrasound-guided vascular intervention: coiling with sclerotherapy for esophageal varices

In recent years, interventional endoscopic ultrasound (EUS) has been applied to the treatment of vascular lesions such as isolated gastric varices and intractable gastrointestinal bleeding [1]. For esophageal varices, it is usual to perform endoscopic injection sclerotherapy (EIS) or endoscopic variceal ligation (EVL) [2] [3]; however, varices of thick diameter without palisade vessels (so-called pipeline varices) are often difficult to treat [4]. This report is the worldʼs first of a new treatment for EUS-guided vascular intervention using a combination of coiling with sclerotherapy for esophageal varices.

[Video 1] shows a typical case. The patient, a 57-year-old man, had alcoholic cirrhosis and thick esophageal varices ([Fig. 1]). Contrast-enhanced computed tomography (3D-CT) and an EUS showed pipeline varix hemodynamics that fed from the left gastric vein to the azygos vein ([Fig. 2] and [Fig. 3]). First, an overtube was inserted; EVL was then performed on the varices on the proximal side. The varices were then punctured using a 19G fine-needle aspiration needle (EZ shot3 plus; Olympus Corp., Tokyo, Japan) near the junction. A 0.035-inch hydrocoil (Azur; Terumo Corp., Tokyo, Japan) was placed. The blood flow was checked by injecting a contrast medium and using the EUS color Doppler function and some additional coils were placed. A sclerosant (ethanolamine oleate) was injected into the feeder vessel ([Fig. 4]), with subsequent cessation of the blood flow. After 1 week, it was confirmed that blood flow had been completely stopped with only the one session of treatment ([Fig. 5]). Moreover, no adverse events occurred.

A new single-session treatment is performed for pipeline esophageal varices consisting of endoscopic ultrasound-guided vascular intervention with a combination of coiling and sclerotherapy.Video 1

Fig. 1 Endoscopic image of thick, highly developed varices at 2 oʼclock.

Fig. 2 3D computed tomography image showing the hemodynamics of a pipeline varix (red arrows) that fed from the left gastric vein (yellow arrow) to the azygos vein (yellow arrowhead).

Fig. 3 Endoscopic ultrasound images showing varices in which there were no palisade vessels (yellow arrowheads), with the pipeline varix flowing from left to right (white arrows).

Fig. 4 Fluoroscopic image showing additional coils that were placed, with injection of sclerosant into the feeder vessel.

Fig. 5 3D computed tomography image 1 week after the procedure showing the coils that had been placed (red arrows) and no further evidence of the varices.

EUS-guided vascular intervention for esophageal variceal bleeding has been previously reported [5]; however, our new treatment, coiling and sclerotherapy for esophageal varices, has an effect that combines EVL (local blood flow blocking) and EIS (blood flow control including the blood supply route). It is believed this treatment will contribute greatly, even for thick and intractable esophageal varices.

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Conflict of Interest

The authors declare that they have no conflict of interest.

• References

• 1 Irisawa A, Shibukawa G, Hoshi K. et al. Endoscopic ultrasound-guided coil deployment with sclerotherapy for isolated gastric varices: Case series of feasibility, safety, and long-term follow-up. Dig Endosc 2020; 32: 1100-1104
• 2 Trolle E, Trolle D. Treatment of oesophageal varices by injection sclerosing agents through oesophagoscope in splenoectomized patients suffering from splenic phlebostenosis (splenic anemia) – A case with autopsy. Acta Chirr Scand 1946; 94: 385-396
• 3 Van Stiegmann G, Goff JS. Endoscopic esophageal varix ligation: preliminary clinical experience. Gastrointest Endosc 1988; 34: 113-117
• 4 Toyonaga A, Iwao T, Sumino M. et al. Distinctive portal venographic pattern in patients with sclerotherapy resistant oesophageal varices. J Gastroenterol Hepatol 1996; 11: 1110-1114
• 5 Rivory J, Pioche M, Dumortier J. et al. Transesophageal endoscopic ultrasound-guided coil and cyanoacrylate treatment of challenging esophageal varices bleeding associated with CREST syndrome ulcerative esophagitis. Endoscopy 2022; 54: E761-E762

Publikationsverlauf

Artikel online veröffentlicht:
08. November 2024