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Nuklearmedizin 2025; 64(02): 177-179
DOI: 10.1055/a-2511-6595
Case Report

Pancreatic Neuroendocrine Tumor incidentally found on 68Ga-PSMA PET/CT

Neuroendokriner Tumor der Bauchspeicheldrüse, zufällig im 68Ga-PSMA-PET/CT entdeckt
Rodrigo Luna
1   The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins Medical Institutions, Baltimore, USA
,
Daniel A. Laheru
1   The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins Medical Institutions, Baltimore, USA
,
Eun Ji Shin
1   The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins Medical Institutions, Baltimore, USA
,
Chen Lossos
1   The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins Medical Institutions, Baltimore, USA
,
Mahalia T. Robinson
1   The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins Medical Institutions, Baltimore, USA
,
Steven P. Rowe
2   University of North Carolina, chapel hill, United States
,
Elie Saad
1   The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins Medical Institutions, Baltimore, USA
,
Mark C. Markowski
1   The Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins Medical Institutions, Baltimore, USA
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Prostate-specific membrane antigen (PSMA) is highly expressed on prostate cancer (PCa) epithelial cells as well as the tumor neovascularity many other neoplasms. We present a case of a 67-year-old man with biochemically recurrent PCa who underwent 68Ga-PSMA-11 PET/CT, which demonstrated an intensely radiotracer-avid pancreatic neuroendocrine tumor. This case demonstrates the equivocal nature of pancreatic lesions, and reinforces the need for further work-up of unusual patterns of uptake, on PSMA-targeted PET/CT. The differential diagnosis of a radiotracer-avid pancreatic lesion should include primary malignancies, among them adenocarcinoma and neuroendocrine tumors.

Keywords

PET/CT - PSMA - Prostate cancer - Neuroendocrine tumors - Biochemical recurrence - Prostate-specific antigen


Publication History

Received: 09 December 2024

Accepted: 27 December 2024

Article published online:
17 April 2025

© 2025. Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

 

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