RSS-Feed abonnieren
DOI: 10.1055/a-2536-6414
The Sun – Friend and Foe for Children and Adolescents. An Update on Acquired Photodermatoses
Die Sonne – Freund und Feind für Kinder und Jugendliche. Ein Update zu erworbenen Photodermatosen
Abstract
Introduction
The ultraviolet radiation – although a small part of the electromagnetic spectrum – is responsible for most photodermatoses in humans.
Material and methods
We performed a narrative literature review using Pubmed on acquired photodermatoses in children and adolescents.
Results
In children and adolescents acute and chronic light eruptions, and exogenous photosensitization including photo-aggravated atopic dermatitis are observed. Clinical examination, medical and drug history, and photo-testing are the mainstay of diagnostics. In some cases, photo-provocation, histopathology and genetic analysis are necessary to confirm the diagnosis. In contrast to adults, chronic photodermatoses are less common.
Conclusions
Acquired photodermatoses are not uncommon during childhood. Sun protection by behavioral changes, clothing and sunscreens are the essentials of any treatment.
Zusammenfassung
Einleitung
Die ultraviolette Strahlung – obwohl sie nur einen kleinen Teil des elektromagnetischen Spektrums ausmacht – ist für die meisten Photodermatosen beim Menschen verantwortlich.
Material und Methoden
Wir führten eine narrative Literaturrecherche mit Pubmed zu erworbenen Photodermatosen bei Kindern und Jugendlichen durch.
Ergebnisse
Bei Kindern und Jugendlichen werden akute und chronische Lichteruptionen sowie exogene Photosensibilisierung einschließlich lichtverschlimmerter atopischer Dermatitis beobachtet. Klinische Untersuchungen, Anamnese und Fotountersuchungen sind die Hauptstützen der Diagnostik. In einigen Fällen sind Photoprovokation, Histopathologie und genetische Analyse notwendig, um die Diagnose zu bestätigen. Im Gegensatz zu Erwachsenen sind chronische Photodermatosen seltener.
Schlussfolgerungen
Erworbene Photodermatosen sind im Kindesalter keine Seltenheit. Sonnenschutz durch Verhaltensänderungen, Kleidung und Sonnenschutzmittel sind das A und O jeder Behandlung.
Publikationsverlauf
Artikel online veröffentlicht:
24. April 2025
© 2025. Thieme. All rights reserved.
Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
-
References
- 1 Christensen L, Suggs A, Baron E. Ultraviolet photobiology in dermatology. Adv Exp Med Biol 2017; 996: 89-104
- 2 Austin E, Geisler AN, Nguyen J. et al. Visible light. Part I: Properties and cutaneous effects of visible light. J Am Acad Dermatol 2021; 84: 1219-1231
- 3 Horton L, Brady J, Kincaid CM. et al. The effects of infrared radiation on the human skin. Photodermatol Photoimmunol Photomed 2023; 39: 549-555
- 4 Holick MF. Biological effects of sunlight, ultraviolet radiation, visible light, infrared radiation and vitamin D for health. Anticancer Res 2016; 36: 1345-1356
- 5 Cho S, Shin MH, Kim YK. et al. Effects of infrared radiation and heat on human skin aging in vivo. J Investig Dermatol Symp Proc 2009; 14: 15-19
- 6 Pourang A, Tisack A, Ezekwe N. et al. Effects of visible light on mechanisms of skin photoaging. Photodermatol Photoimmunol Photomed 2022; 38: 191-196
- 7 Yew YW, Giordano CN, Spivak G. et al. Understanding photodermatoses associated with defective DNA repair: Photosensitive syndromes without associated cancer predisposition. J Am Acad Dermatol 2016; 75: 873-882
- 8 Giordano CN, Yew YW, Spivak G. et al. Understanding photodermatoses associated with defective DNA repair: Syndromes with cancer predisposition. J Am Acad Dermatol 2016; 75: 855-870
- 9 Lehmann H. Photodermatoses. In: Plewig G, French L, Ruzicka T. et al. , ed. Braun-Falco’s Dermatology. 4th. Berlin: Springer Nature; 2022: 752-754
- 10 Loyal J, Sinclair NR, Hugh JM. et al. Sunburn purpura. Cutis 2017; 100: E15-E17
- 11 Van Laethem A, Claerhout S, Garmyn M. et al. The sunburn cell: regulation of death and survival of the keratinocyte. Int J Biochem Cell Biol 2005; 37: 1547-1553
- 12 Braun HA, Adler CH, Goodman M. et al. Sunburn frequency and risk and protective factors: a cross-sectional survey. Dermatol Online J 2021; 27: 13030/qt6qn7k2gp
- 13 Költő A, Rodriguez L, McAvoy H. et al. Sunburn, sun safety and indoor tanning among schoolchildren in Ireland. Int J Public Health 2021; 66: 1604045
- 14 Görig T, Apfelbacher C, Drewitz KP. et al. Sunburn and sun protection during recreational outdoor sport in summer: Findings from the German general population aged 16–65 years. Photodermatol Photoimmunol Photomed 2023; 39: 589-597
- 15 Dowd MD. Treatment and prevention of pediatric sunburn. Pediatr Ann 2019; 48: e213-e214
- 16 Wollina U, Helm C, Bennewitz A. et al. Interventional three-year longitudinal study of melanocytic naevus development in pre-school children in Dresden, Saxony. Acta Derm Venereol 2014; 94: 63-66
- 17 Leroy D, Dompmartin A, Verneuil L. et al. La lucite estivale bénigne existe-t-elle? [Does benign summer light eruption exist?]. Ann Dermatol Venereol 2002; 129: 855-858
- 18 Guarrera M, Cardo P, Rebora AE. et al. Polymorphous light eruption and benign summer light eruption in Italy. Photodermatol Photoimmunol Photomed 2011; 27: 35-39
- 19 Marguery MC, Tremeau-Martinage C, el Sayed F. et al. Eruption estivale photodeclenchée récidivante des régions axillaires et inguinales: une forme topographique atypique de lucite estivale bénigne [Recurrent phototriggered summer light eruption of the axillary and inguinal area: an atypical topographic form of benign summer lucitis]. Ann Dermatol Venereol 1996; 123: 824-826
- 20 Totten JE, Brock DM, Schimelpfenig TD. et al. Prolonged exposure dermatosis: reporting high incidence of an undiagnosed facial dermatosis on a winter wilderness expedition. Wilderness Environ Med 2015; 26: 525-530
- 21 Kılıç Sayar S. Juvenile spring eruption among soldiers: A report of a large outbreak. Australas J Dermatol 2021; 62: e265-e266
- 22 Tan E, Eberhart-Phillips J, Sharples K. Juvenile spring eruption: a prevalence study. N Z Med J 1996; 109: 293-295
- 23 Stratigos AJ, Antoniou C, Papadakis P. et al. Juvenile spring eruption: clinicopathologic features and phototesting results in 4 cases. J Am Acad Dermatol 2004; 50 (Suppl. 2) S57-S60
- 24 Lava SA, Simonetti GD, Ragazzi M. et al. Juvenile spring eruption: an outbreak report and systematic review of the literature. Br J Dermatol 2013; 168: 1066-1072
- 25 Zarfl M, Patra V, Bordag N. et al. Eradication of skin microbiota restores cytokine production and release in polymorphic light eruption. Exp Dermatol 2024; 33: e15034
- 26 Gruber-Wackernagel A, Byrne SN, Wolf P. Polymorphous light eruption: clinic aspects and pathogenesis. Dermatol Clin 2014; 32: 315-334
- 27 Wollina U, Schaarschmidt H, Knopf B. et al. Modulation of antibody binding to double-stranded (ds) DNA and Ro/SSA antigens by UV-irradiation of human epidermis in vitro. Studia Biophysica 1988; 124: 251-258
- 28 Hadshiew IM, Treder-Conrad C, von Bülow R. et al. Polymorphous light eruption (PLE) and a new potent antioxidant and UVA-protective formulation as prophylaxis. Photodermatol Photoimmunol Photomed 2004; 20: 200-204
- 29 Wollina U, Hein G. Lupus erythematosus: uncommon presentations. Clin Dermatol 2005; 23: 470-479
- 30 Duteil L, Queille-Roussel C, Aladren S. et al. Prevention of polymorphic light eruption afforded by a very high broad-spectrum protection sunscreen containing ectoin. Dermatol Ther (Heidelb) 2022; 12: 1603-1613
- 31 Ortel B, Wechdorn D, Tanew A. et al. Effect of nicotinamide on the phototest reaction in polymorphous light eruption. Br J Dermatol 1988; 118: 669-673
- 32 Tanew A, Radakovic S, Gonzalez S. et al. Oral administration of a hydrophilic extract of Polypodium leucotomos for the prevention of polymorphic light eruption. J Am Acad Dermatol 2012; 66: 58-62
- 33 Lembo S, Raimondo A. Polymorphic light eruption: what's new in pathogenesis and management. Front Med (Lausanne) 2018; 5: 252
- 34 Patel DC, Bellaney GJ, Seed PT. et al. Efficacy of short-course oral prednisolone in polymorphic light eruption: a randomized controlled trial. Br J Dermatol 2000; 143: 828-831
- 35 Ling TC, Gibbs NK, Rhodes LE. Treatment of polymorphic light eruption. Photodermatol Photoimmunol Photomed 2003; 19: 217-227
- 36 Huggins RH, Leithauser LA, Eide MJ. et al. Quality of life assessment and disease experience of patient members of a web-based hydroa vacciniforme support group. Photodermatol Photoimmunol Photomed 2009; 25: 209-215
- 37 Rice AS, Bermudez R. Hydroa Vacciniforme. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024
- 38 Zhang Y, Liu Y, Xu J. et al. Hydroa vacciniforme lymphoproliferative disorder: a retrospective study of 42 paediatric cases. Eur J Dermatol 2024; 34: 144-149
- 39 Chong WS, Khoo SW. Solar urticaria in Singapore: an uncommon photodermatosis seen in a tertiary dermatology center over a 10-year period. Photodermatol Photoimmunol Photomed 2004; 20: 101-104
- 40 Uetsu N, Murata C, Okamoto H. Childhood fixed solar urticaria induced by visible light. Photodermatol Photoimmunol Photomed 2023; 39: 159-161
- 41 Tanaka N, Fukumoto T, Otsuka H. et al. A case of solar urticaria with inhibition spectrum in ultraviolet radiation A and visible light successfully treated by ultraviolet radiation A rush hardening therapy. J Dermatol 2025; 52: e149-e150
- 42 Imamura S, Oda Y, Fukumoto T. et al. Solar urticaria: clinical characteristics, treatment effectiveness, long-term prognosis, and QOL status in 29 patients. Front Med (Lausanne) 2024; 11
- 43 Balakirski G, Gäbelein-Wissing N, Hofmann SC. Lichturtikaria und polymorphe Lichtdermatose [Solar urticaria and polymorphous light eruption]. Dermatologie (Heidelb) 2024; 75: 518-527
- 44 Casanova-Esquembre A, Lorca-Spröhnle J, Peñuelas-Leal R. et al. Solar urticaria and omalizumab: a retrospective case–control study and follow-up. Actas Dermosifiliogr 2024; 115: 931-932
- 45 Boontaveeyuwat E, Willis F, Fassihi H. et al. Successful serial plasmapheresis for solar urticaria, a case report and literature review. J Dermatolog Treat 2024; 35
- 46 Hershkovitz Y, Khanimov I, Rubin L. et al. Successful ligelizumab treatment of severe refractory solar urticaria. J Allergy Clin Immunol Pract 2023; 11: 2576-2577
- 47 Navarro-Triviño FJ, Prados-Carmona A, Aguilera J. et al. Treatment of refractory solar urticaria: could dupilumab fill the current gap?. J Dtsch Dermatol Ges 2023; 21: 652-653
- 48 Alamillo-Velazquez J, Ortiz-Morales G, Gonzalez-Gonzalez SE. et al. Actinic conjunctivitis and its relationship with prurigo in an indigenous population from the Highlands of Chiapas, Mexico. Int Ophthalmol 2024; 44: 4
- 49 Pardo-Zamudio AC, Valbuena MC, Jiménez-Torres HD. et al. Actinic prurigo in a dermatological reference center in Colombia: 108 cases. Biomedica 2020; 40: 487-497
- 50 Batard ML, Bonnevalle A, Ségard M. et al. Caucasian actinic prurigo: 8 cases observed in France. Br J Dermatol 2001; 144: 194-196
- 51 Lee CN, Chen TY, Wong TW. The immunogenetics of photodermatoses. Adv Exp Med Biol 2022; 1367: 369-381
- 52 Vega Memije ME, Cuevas Gonzalez JC, Hojyo-Tomoka MT. et al. Actinic prurigo as a hypersensitivity reaction type 4. Int J Dermatol 2017; 56: e135-e136
- 53 Lane PR, Murphy F, Hogan DJ. et al. Histopathology of actinic prurigo. Am J Dermatopathol 1993; 15: 326-331
- 54 Pile HD, Crane JS. Actinic Prurigo. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024
- 55 Peruilh-Bagolini L, Jahr-Andrade C, Gárate-González M. et al. Hydroxychloroquine in the treatment of actinic prurigo in pediatric patients: Report of three cases. J Dtsch Dermatol Ges 2022; 20: 1226-1227
- 56 Malekan M, Mohandesi NA, Rahmatpour Rokni G. et al. Successful treatment of actinic prurigo with baricitinib in an 8-year-old child: A case report. Pediatr Dermatol 2024; 41: 1159-1161
- 57 Shah A, Mittal S, Tollefson MM. et al. Treatment of actinic prurigo with dupilumab in an adolescent. Int J Dermatol 2025; 64: 167-168
- 58 Barker CS, Sattele L, Strat N. et al. Dupilumab as treatment of actinic prurigo suggests pathophysiologic mechanism of disease: A case series. JAAD Case Rep 2024; 46: 89-91
- 59 Sardana K, Muddebihal A. Successful treatment of refractory late-onset actinic prurigo with tofacitinib. Int J Dermatol 2024; 63: e448-e449
- 60 Avenel-Audran M, Dutartre H, Goossens A. et al. Octocrylene, an emerging photoallergen. Arch Dermatol 2010; 146: 753-757
- 61 Klaber RE. Phytophotodermatitis. Arch Dis Child 2006; 91: 385
- 62 Victor FC, Cohen DE, Soter NA. A 20-year analysis of previous and emerging allergens that elicit photoallergic contact dermatitis. J Am Acad Dermatol 2010; 62: 605-610
- 63 Hu Y, Wang D, Shen Y. et al. Photopatch testing in Chinese patients over 10 years. Dermatitis 2016; 27: 137-142
- 64 Tanahashi T, Sasaki K, Numata M. et al. Three cases of photoallergic contact dermatitis induced by benzophenone in amusement park wristbands. Contact Dermatitis 2019; 80: 191-193
- 65 Haylett AK, Chiang YZ, Nie Z. et al. Sunscreen photopatch testing: a series of 157 children. Br J Dermatol 2014; 171: 370-375
- 66 Dawe RS, Ibbotson SH. Drug-induced photosensitivity. Dermatol Clin 2014; 32: 363-368
- 67 Musters AH, Mashayekhi S, Harvey J. et al. Phototherapy for atopic eczema. Cochrane Database Syst Rev 2021; 10
- 68 Ellenbogen E, Wesselmann U, Hofmann SC. et al. Photosensitive atopic dermatitis – a neglected subset: Clinical, laboratory, histological and photobiological workup. J Eur Acad Dermatol Venereol 2016; 30: 270-275
- 69 Rutter KJ, Farrar MD, Marjanovic EJ. et al. Clinicophotobiological characterization of photoaggravated atopic dermatitis. JAMA Dermatol 2022; 158: 1022-1030
- 70 Gao H, Zhang Z, Ma L. et al. Photosensitivity is an important cause of refractory facial erythema in atopic dermatitis: A retrospective study of 82 Chinese patients. Photodermatol Photoimmunol Photomed 2023; 39: 318-324
- 71 Vandermaesen J, Roelandts R, Degreef H. Light on the persistent light reaction-photosensitivity dermatitis-actinic reticuloid syndrome. J Am Acad Dermatol 1986; 15: 685-692
- 72 Creamer D, McGregor JM, Hawk JL. Chronic actinic dermatitis occurring in young patients with atopic dermatitis. Br J Dermatol 1998; 139: 1112-1113
- 73 Tan KW, Haylett AK, Ling TC. et al. Comparison of demographic and photobiological features of chronic actinic dermatitis in patients with lighter vs darker skin types. JAMA Dermatol 2017; 153: 427-435
- 74 Tiwari DK, Goyal M. Pavithran nose sign. J Cutan Med Surg 2023; 27: 543
- 75 Paek SY, Lim HW. Chronic actinic dermatitis. Dermatol Clin 2014; 32: 355-361
- 76 Holmes Z, Foley P, Baker C. et al. Dupilumab for chronic actinic dermatitis: A case series and review of the literature. Australas J Dermatol 2024; 65: 287-291
- 77 Hamel R, Mohammad TF, Chahine A. et al. Comparison of racial distribution of photodermatoses in USA academic dermatology clinics: A multicenter retrospective analysis of 1080 patients over a 10-year period. Photodermatol Photoimmunol Photomed 2020; 36: 233-240
- 78 Görig T, Södel C, Pfahlberg AB. et al. Sun protection and sunburn in children aged 1–10 years in Germany: prevalence and determinants. Children (Basel) 2021; 8: 668
- 79 de Troya-Martín M, de Gálvez-Aranda MV, Rivas-Ruiz F. et al. Prevalence and predictors of sunburn among beachgoers. Photodermatol Photoimmunol Photomed 2018; 34: 122-129
- 80 Buller DB, Cokkinides V, Hall HI. et al. Prevalence of sunburn, sun protection, and indoor tanning behaviors among Americans: review from national surveys and case studies of 3 states. J Am Acad Dermatol 2011; 65 (Suppl. 1) S114-S123
- 81 Wei G, Farooq J, Castelo-Soccio L. et al. Correlates between physical activity and sunburn prevalence among a nationally representative sample of US high school students, 2015–2017. J Phys Act Health 2021; 18: 1113-1119
- 82 Ackermann S, Vuadens A, Levi F. et al. Sun protective behaviour and sunburn prevalence in primary and secondary schoolchildren in western Switzerland. Swiss Med Wkly 2016; 146
- 83 Költő A, Rodriguez L, McAvoy H. et al. Sunburn, sun safety and indoor tanning among schoolchildren in Ireland. Int J Public Health 2021; 66: 1604045
- 84 Rogers C, Kvaskoff M, DiSipio T. et al. Prevalence and determinants of sunburn in Queensland. Health Promot J Austr 2009; 20: 102-106
- 85 Burfield L, Rutter KJ, Thompson B. et al. Systematic review of the prevalence and incidence of the photodermatoses with meta-analysis of the prevalence of polymorphic light eruption. J Eur Acad Dermatol Venereol 2023; 37: 511-520
- 86 Gutierrez D, Gaulding JV, Motta Beltran AF. et al. Photodermatoses in skin of colour. J Eur Acad Dermatol Venereol 2018; 32: 1879-1886
- 87 Han B, Hur K, Ohn J. et al. Hydroa vacciniforme-like lymphoproliferative disorder in Korea. Sci Rep 2020; 10: 19294
- 88 Pérez-Ferriols A, Barnadas M, Gardeazábal J. del Grupo Español de Fotobiología. et al. Solar urticaria: Epidemiology and clinical phenotypes in a Spanish series of 224 patients. Actas Dermosifiliogr 2017; 108: 132-139
- 89 Pardo-Zamudio AC, Valbuena MC, Jiménez-Torres HD. et al. Actinic prurigo in a dermatological reference center in Colombia: 108 cases. Biomédica 2020; 40: 487-497
- 90 Nakamura M, Henderson M, Jacobsen G. et al. Comparison of photodermatoses in African-Americans and Caucasians: a follow-up study. Photodermatol Photoimmunol Photomed 2014; 30: 231-236
- 91 Shao Y, Hu Y, Wang D. et al. Photopatch testing in Chinese patients: A 5-year experience. Contact Dermatitis 2021; 85: 78-84
- 92 Lim SYD, Goon AT, Leow YH. et al. Photopatch testing in Singapore: A 10-year retrospective study. Photodermatol Photoimmunol Photomed 2023; 39: 642-647
- 93 Bryden AM, Moseley H, Ibbotson SH. et al. Photopatch testing of 1155 patients: results of the U.K. multicentre photopatch study group. Br J Dermatol 2006; 155: 737-747
- 94 Neumann NJ, Hölzle E, Plewig G. et al. Photopatch testing: the 12-year experience of the German, Austrian, and Swiss photopatch test group. J Am Acad Dermatol 2000; 42: 183-192
- 95 Wadhwani AR, Sharma VK, Ramam M. et al. A clinical study of the spectrum of photodermatoses in dark-skinned populations. Clin Exp Dermatol 2013; 38: 823-829
- 96 Stöver LA, Hinrichs B, Petzold U. et al. Getting in early: primary skin cancer prevention at 55 German kindergartens. Br J Dermatol 2012; 167 (Suppl. 2) 63-69
- 97 Raymond-Lezman JR, Riskin S. Attitudes, behaviors, and risks of sun protection to prevent skin cancer amongst children, adolescents, and adults. Cureus 2023; 15
- 98 Diehl K, Thoonen K, Breitbart EW. et al. Sun protection and tanning behaviors in caregivers: prevalence, determinants, and associations with children's behaviors. Int J Environ Res Public Health 2022; 19: 6876
- 99 OʼHara M, Horsham C, Koh U. et al. Unintended sunburn after sunscreen application: An exploratory study of sun protection. Health Promot J Austr 2020; 31: 533-539
- 100 Wollina U. Sunscreens are no harmless substitutes for mindful behavior under the sun. Dermatol Ther 2018; 31: e12733
- 101 Surber C, Plautz J, Sohn M. et al. Percutaneous absorption of sunscreen filters: review of issues and challenges. Curr Probl Dermatol 2021; 55: 188-202
- 102 US Food & Drug Administration. Facts about Sunscreens. 2024 Zugriff am 12. November 2024 unter: https://www.fda.gov/news-events/rumor-control/facts-about-sunscreen
- 103 Moschetti A, Rana P, Pucci Romano MC. et al. Position Paper on the use of sunscreens. Eur J Pediatr Dermatol 2024; 34: 54-57
- 104 Garnacho Saucedo GM, Salido Vallejo R, Moreno Giménez JC. Efectos de la radiación solar y actualización en fotoprotección [Effects of solar radiation and an update on photoprotection]. An Pediatr (Barc) 2020; 92: 380
- 105 Mestari Z, Cohen BA. Sun-safe practices in different pediatric patients. Contemp PEDS J 2024; 40: 22-24
- 106 Kahremany S, Hofmann L, Gruzman A. et al. NRF2 in dermatological disorders: Pharmacological activation for protection against cutaneous photodamage and photodermatosis. Free Radic Biol Med 2022; 188: 262-276
- 107 Walker H, Maitland C, Tabbakh T. et al. Forty years of Slip! Slop! Slap! A call to action on skin cancer prevention for Australia. Public Health Res Pract 2022; 32
- 108 Harrison SL, Buettner PG, Nowak MJ. Sun-protective clothing worn regularly during early childhood reduces the number of new melanocytic nevi: the North Queensland Sun-Safe Clothing Cluster Randomized Controlled Trial. Cancers (Basel) 2023; 15: 1762