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Horm Metab Res 2025; 57(04): 262-272
DOI: 10.1055/a-2554-4861
Original Article: Endocrine Care

A Breast Cancer Prognostic Model Based on Folic Acid Metabolism-Related Genes to Reveal the Immune Landscape

Lin Lv
1   Department of Breast and Thyroid Surgery, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China
,
Xiaotao Zhu 
1   Department of Breast and Thyroid Surgery, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China
,
Cong Jin
1   Department of Breast and Thyroid Surgery, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China
,
Shunlan Ni
2   Department of Infectious Diseases, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China
› InstitutsangabenGefördert durch: The Public Welfare Projects of Jinhua Science and Technology Bureau, Zhejiang Province 2022-4-103
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Abstract

Breast cancer (BC) threatens women’s health, and the prognosis is dismal. Folic acid metabolism affects cancer prognosis, but research on folic acid metabolism-related genes (FMRs) in BC is scarce. We used TCGA-BRCA as the training set and GSE21653 as the validation set. Five FMRs (PLAT, SERPINA3, IFNG, SLC19A1, NFKB2) were screened via univariate and LASSO Cox regression analyses, and a prognostic model was built based on multivariate Cox regression analysis. The model showed excellent predictive performance. Differentially expressed genes in high- and low-risk groups were enriched in steroid hormone biosynthesis and neuroactive ligand-receptor interaction pathways. The low-risk group exhibited higher immune cell infiltration and better immunotherapy response. AM-5992 and 5-fluorodeoxyuridine 10mer may be potential BC drugs. This FMR-based model can accurately predict BC prognosis, offering a clinical reference.

Keywords

folic acid metabolism - breast cancer - feature genes - prognostic analysis

Supplementary Material



Publikationsverlauf

Eingereicht: 08. Januar 2025

Angenommen nach Revision: 05. März 2025

Artikel online veröffentlicht:
10. April 2025

© 2025. Thieme. All rights reserved.

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Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

 

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