J Reconstr Microsurg
DOI: 10.1055/a-2555-2348
Original Article

Abdominal Wall Reinforcement Using OviTex after Deep Inferior Epigastric Perforator Flap

1   Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado
,
Caitlin Blades
1   Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado
,
Steven Dawson
1   Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado
,
Jose A. Foppiani
2   Department of Plastic and Reconstructive Surgery, Beth Isreal Deaconess Medical Center, Boston, Massachusetts
,
Taylor Allenby
1   Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado
,
Julian Winocour
1   Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado
,
Justin Cohen
1   Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado
,
1   Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado
,
1   Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado
› Author Affiliations

Abstract

Background

Abdominal wall bulges and hernias are not uncommon complications following deep inferior epigastric perforator (DIEP) flap harvest. Abdominal wall reinforcement using synthetic meshes has been found to decrease bulges by up to 70%; however, such meshes can be associated with other issues such as seromas and infections. Reinforced tissue matrix (RTM) mesh can be used for abdominal wall reinforcement due to its ability to recruit fibroblasts and provide a scaffold for cellular proliferation. There is no literature on the use of OviTex mesh for abdominal wall reinforcement following DIEP flap harvest. Therefore, this study aimed to evaluate the efficacy and safety of its use in this setting.

Methods

A retrospective review was performed on patients undergoing DIEP flap harvest between January 2020 and June 2023. Patients who had completed at least 12 months of follow-up visits were included. Descriptive, univariate, and multiple logistic regression analyses were completed.

Results

A total of 199 patients were included. The mean age at the time of surgery was 51.1 ± 10.0 years and the mean body mass index (BMI) was 30.2 ± 5.9 kg/m2. Abdominal wall reinforcement was completed in 85 (42.7%) patients. Patients who had OviTex placed developed fewer bulges compared to the non-mesh cohort (0% vs. 5.3%, p = 0.04). Furthermore, OviTex mesh did not increase adverse events and was not significantly different in seroma/hematoma rates when compared to the non-mesh cohort (10.6% vs. 5.3%, p = 0.26).

Conclusion

This study demonstrates that OviTex mesh is safe and efficacious in reducing the rate of bulges following DIEP flap harvest without increasing other complications.

Note

Poster presentation at the American Society of Reconstructive Microsurgery Annual Meeting, January 13, 2024.

Oral presentation at the Mountain West Society of Plastic Surgery Annual Meeting, March 8, 2024.




Publication History

Received: 24 November 2024

Accepted: 19 February 2025

Accepted Manuscript online:
11 March 2025

Article published online:
01 April 2025

© 2025. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 
  • References

  • 1 Chang EI, Chang EI, Soto-Miranda MA. et al. Comprehensive analysis of donor-site morbidity in abdominally based free flap breast reconstruction. Plast Reconstr Surg 2013; 132 (06) 1383-1391
  • 2 Butler DP, Plonczak AM, Reissis D. et al. Factors that predict deep inferior epigastric perforator flap donor site hernia and bulge. J Plast Surg Hand Surg 2018; 52 (06) 338-342
  • 3 Haddock NT, Culver AJ, Teotia SS. Abdominal weakness, bulge, or hernia after DIEP flaps: An algorithm of management, prevention, and surgical repair with classification. J Plast Reconstr Aesthet Surg 2021; 74 (09) 2194-2201
  • 4 Pulikkottil BJ, Pezeshk RA, Daniali LN, Bailey SH, Mapula S, Hoxworth RE. Lateral abdominal wall defects: The importance of anatomy and technique for a successful repair. Plast Reconstr Surg Glob Open 2015; 3 (08) e481
  • 5 Futter CM, Webster MH, Hagen S, Mitchell SL. A retrospective comparison of abdominal muscle strength following breast reconstruction with a free TRAM or DIEP flap. Br J Plast Surg 2000; 53 (07) 578-583
  • 6 Shubinets V, Fox JP, Sarik JR, Kovach SJ, Fischer JP. Surgically treated hernia following abdominally based autologous breast reconstruction: Prevalence, outcomes, and expenditures. Plast Reconstr Surg 2016; 137 (03) 749-757
  • 7 Mennie JC, Mohanna PN, O'Donoghue JM, Rainsbury R, Cromwell DA. Donor-site hernia repair in abdominal flap breast reconstruction: A population-based cohort study of 7929 patients. Plast Reconstr Surg 2015; 136 (01) 1-9
  • 8 Tomouk T, Mohan AT, Azizi A, Conci E, Brickley EB, Malata CM. Donor site morbidity in DIEP free flap breast reconstructions: A comparison of unilateral, bilateral, and bipedicled surgical procedure types. J Plast Reconstr Aesthet Surg 2017; 70 (11) 1505-1513
  • 9 Ingvaldsen CA, Bosse G, Mynarek GK, Berg T, Tindholdt TT, Tønseth KA. Donor-site morbidity after DIEAP flap breast reconstruction-A 2-year postoperative computed tomography comparison. Plast Reconstr Surg Glob Open 2017; 5 (07) e1405
  • 10 Uda H, Kamochi H, Sarukawa S, Sunaga A, Sugawara Y, Yoshimura K. Clinical and quantitative isokinetic comparison of abdominal morbidity and dynamics following DIEP versus muscle-sparing free TRAM flap breast reconstruction. Plast Reconstr Surg 2017; 140 (06) 1101-1109
  • 11 Jakeman M, Barnes J, Taghizadeh R. Prevention and management of post-deep inferior epigastric perforator flap abdominal bulge: A 5-year single-surgeon series. J Plast Reconstr Aesthet Surg 2022; 75 (10) 3683-3689
  • 12 Siegwart LC, Sieber L, Fischer S. et al. The use of semi-absorbable mesh and its impact on donor-site morbidity and patient-reported outcomes in DIEP flap breast reconstruction. Aesthetic Plast Surg 2021; 45 (03) 907-916
  • 13 Pereira C, Gururaj S. Onlay versus sublay mesh repair for incisional hernias: A systematic review. Cureus 2023; 15 (01) e34156
  • 14 Mavros MN, Athanasiou S, Alexiou VG, Mitsikostas PK, Peppas G, Falagas ME. Risk factors for mesh-related infections after hernia repair surgery: a meta-analysis of cohort studies. World J Surg 2011; 35 (11) 2389-2398
  • 15 DeNoto III G, Ceppa EP, Pacella SJ. et al. A prospective, single arm, multi-center study evaluating the clinical outcomes of ventral hernias treated with OviTex® 1S Permanent Reinforced Tissue Matrix: The BRAVO Study 12-Month Analysis. J Clin Med 2021; 10 (21) 4998
  • 16 Kokotovic D, Bisgaard T, Helgstrand F. Long-term recurrence and complications associated with elective incisional hernia repair. JAMA 2016; 316 (15) 1575-1582
  • 17 Sawyer M, Ferzoco S, DeNoto III G. A polymer-biologic hybrid hernia construct: Review of data and early experiences. Polymers (Basel) 2021; 13 (12) 1928
  • 18 von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP. STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 2007; 370 (9596) 1453-1457
  • 19 Wormer BA, Clavin NW, Lefaivre JF. et al. Reducing postoperative abdominal bulge following deep inferior epigastric perforator flap breast reconstruction with Onlay monofilament poly-4-hydroxybutyrate biosynthetic mesh. J Reconstr Microsurg 2017; 33 (01) 8-18
  • 20 Wang XC, Zhang D, Yang ZX, Gan JX, Yin LN. Mesh reinforcement for the prevention of incisional hernia formation: a systematic review and meta-analysis of randomized controlled trials. J Surg Res 2017; 209: 17-29
  • 21 Rhemtulla IA, Mauch JT, McCarty EB, Broach RB, Serletti JM, Kovach SJ. Incisional hernia incidence, repair techniques, and outcomes based on 1600 consecutive patients receiving abdominally based autologous breast reconstruction. Ann Plast Surg 2021; 87 (01) 85-90
  • 22 Razavi SA, Desai KA, Hart AM, Thompson PW, Losken A. The impact of mesh reinforcement with components separation for abdominal wall reconstruction. Am Surg 2018; 84 (06) 959-962
  • 23 Hansson E, Edvinsson A-C, Elander A, Kölby L, Hallberg H. First-year complications after immediate breast reconstruction with a biological and a synthetic mesh in the same patient: A randomized controlled study. J Surg Oncol 2021; 123 (01) 80-88
  • 24 Parham MJ, Grush AE, Smerica A. et al. Overview of biologic agents used in skin and soft tissue reconstruction. Semin Plast Surg 2022; 36 (01) 3-7
  • 25 Adetayo OA, Salcedo SE, Bahjri K, Gupta SC. A meta-analysis of outcomes using acellular dermal matrix in breast and abdominal wall reconstructions: Event rates and risk factors predictive of complications. Ann Plast Surg 2016; 77 (02) e31-e38
  • 26 Nahabedian MY, Momen B. Lower abdominal bulge after deep inferior epigastric perforator flap (DIEP) breast reconstruction. Ann Plast Surg 2005; 54 (02) 124-129
  • 27 Lee K-T, Mun G-H. Effects of obesity on postoperative complications after breast reconstruction using free muscle-sparing transverse rectus abdominis myocutaneous, deep inferior epigastric perforator, and superficial inferior epigastric artery flap: A systematic review and meta-analysis. Ann Plast Surg 2016; 76 (05) 576-584
  • 28 Rezania N, Harmon KA, Frauchiger-Ankers R. et al. A DIEP dive into patient risk factors for hernia and bulge development: A meta-regression. J Reconstr Microsurg 2025; 41 (03) 237-247
  • 29 Huang H, Lu Wang M, Chen Y, Chadab TM, Vernice NA, Otterburn DM. A machine learning approach to predicting donor site complications following DIEP flap harvest. J Reconstr Microsurg 2024; 40 (01) 70-77
  • 30 Minossi JG, Lima FdeO, Caramori CA. et al. Alloxan diabetes alters the tensile strength, morphological and morphometric parameters of abdominal wall healing in rats. Acta Cir Bras 2014; 29 (02) 118-124
  • 31 Wen YE, Steppe C, Teotia SS, Haddock NT. Operative time predicts long-term abdominal morbidity and complication requiring treatment after DIEP flap breast reconstruction. J Reconstr Microsurg 2024; 40 (03) 217-226
  • 32 Elver AA, Matthews SA, Egan KG. et al. Characterizing outcomes of medial and lateral perforators in deep inferior epigastric perforator flaps. J Reconstr Microsurg 2023; 39 (01) 20-26
  • 33 Garvey PB, Salavati S, Feng L, Butler CE. Abdominal donor-site outcomes for medial versus lateral deep inferior epigastric artery branch perforator harvest. Plast Reconstr Surg 2011; 127 (06) 2198-2205
  • 34 Hembd A, Teotia SS, Zhu H, Haddock NT. Optimizing perforator selection: A multivariable analysis of predictors for fat necrosis and abdominal morbidity in DIEP flap breast reconstruction. Plast Reconstr Surg 2018; 142 (03) 583-592
  • 35 Grünherz L, Keijzer W, Uyulmaz S. et al. Donor site aesthetics and morbidity after DIEP flap breast reconstruction-A retrospective multicenter study. Breast J 2020; 26 (10) 1980-1986
  • 36 Garvey PB, Buchel EW, Pockaj BA. et al. DIEP and pedicled TRAM flaps: a comparison of outcomes. Plast Reconstr Surg 2006; 117 (06) 1711-1719 , discussion 1720–1721