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Neuropediatrics
DOI: 10.1055/a-2561-8303
Review Article

Bornavirus (BoDV-1) Encephalitis in Children: Update on Diagnosis and Treatment

Victoria Lieftüchter
1   Pediatric Intensive Care Unit, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Germany
2   Department of Pediatric Neurology, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Germany
,
Yannik Vollmuth
1   Pediatric Intensive Care Unit, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Germany
,
Moritz Tacke 
1   Pediatric Intensive Care Unit, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Germany
2   Department of Pediatric Neurology, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Germany
,
Florian Hoffmann
1   Pediatric Intensive Care Unit, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Germany
,
Marco Paolini
3   Department of Radiology, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Germany
,
Tom Finck
4   Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
,
Friederike Liesche-Starnecker
5   Department of Pathology, Medical Faculty, University of Augsburg, Germany
,
Ulrich von Both
6   Department of Pediatric Infectious Diseases, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Germany
,
Kirsten Pörtner
7   Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany
,
Dennis Tappe
8   Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
,
Leonie Grosse
2   Department of Pediatric Neurology, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Germany
› Author Affiliations Funding None.
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Abstract

Infectious encephalitis in children can be caused by several pathogens, very rarely this can be caused by bornaviruses (BoDV-1). Due to the recent discovery of the disease in humans and the small number of cases, especially pediatric infections, knowledge about the disease pathology as well as therapeutic options is limited. Therefore, this review shall help raise awareness of this rare and mostly fatal disease, promote an early diagnosis, and present current knowledge about possible treatment options.

Keywords

inflammatory - BoDV-1 - bornavirus - encephalitis


Publication History

Received: 11 July 2024

Accepted: 15 March 2025

Article published online:
14 April 2025

© 2025. Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

 

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