Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000002.xml
Aktuelle Dermatologie 2025; 51(05): 155-166
DOI: 10.1055/a-2563-8859
DOI: 10.1055/a-2563-8859
State of the Art
Seltene Differenzialdiagnosen beim Ulcus cruris venosum

Chronische Wunden stellen weltweit ein zunehmendes medizinisches und ökonomisches Problem dar. Die am häufigsten auftretenden chronischen Wunden manifestieren sich bei mehr als der Hälfte der Patient*innen als gefäßbedingte Ulzerationen. Die Ursachen für ein Ulcus cruris sind jedoch vielfältig. Insbesondere im dermatologischen Bereich werden häufig Patient*innen mit selteneren Ursachen für Unterschenkelulzerationen vorstellig. In diesem Artikel legen wir den Fokus auf seltene Differenzialdiagnosen des Ulcus cruris venosum (UCV).
Publication History
Article published online:
19 May 2025
© 2024. Thieme. All rights reserved.
Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
-
Literatur
- 1
Manu C,
Lacopi E,
Bouillet B.
et al.
Delayed referral of patients with diabetic foot ulcers across Europe: patterns between
primary care and specialised units. J Wound Care 2018; 27: 186-192
MissingFormLabel
- 2
Falanga V,
Isseroff RR,
Soulika AM.
et al.
Chronic wounds. Nat Rev Dis Primers 2022; 8: 50
MissingFormLabel
- 3 (Hrsg.) D. Lokaltherapie schwerheilender und/oder chronischer Wunden aufgrund von peripherer arterieller Verschlusskrankheit, Diabetes mellitus oder chronisch venöser Insuffizienz. . AWMF-Register-Nr: 091/001 2023; Version 2.1. Stand 11.09.2023.
- 4
Dissemond J.
ABCDE-Regel der Diagnostik chronischer Wunden. J Dtsch Dermatol Ges 2017; 15: 732-734
MissingFormLabel
- 5
Rabe E,
Guex JJ,
Puskas A.
et al.
Epidemiology of chronic venous disorders in geographically diverse populations: results
from the Vein Consult Program. Int Angiol 2012; 31: 105-115
MissingFormLabel
- 6
Korber A,
Klode J,
Al-Benna S.
et al.
Etiology of chronic leg ulcers in 31,619 patients in Germany analyzed by an expert
survey. J Dtsch Dermatol Ges 2011; 9: 116-121
MissingFormLabel
- 7
Maronese CA,
Pimentel MA,
Li MM.
et al.
Pyoderma Gangrenosum: An Updated Literature Review on Established and Emerging Pharmacological
Treatments. Am J Clin Dermatol 2022; 23: 615-634
MissingFormLabel
- 8
Flora A,
Kozera E,
Frew JW.
Pyoderma gangrenosum: A systematic review of the molecular characteristics of disease.
Exp Dermatol 2022; 31: 498-515
MissingFormLabel
- 9
Jockenhofer F,
Wollina U,
Salva KA.
et al.
The PARACELSUS score: a novel diagnostic tool for pyoderma gangrenosum. Br J Dermatol
2019; 180: 615-620
MissingFormLabel
- 10
Yamamoto T,
Yamasaki K,
Yamanaka K.
et al.
Clinical guidance of pyoderma gangrenosum 2022. J Dermatol 2023; 50: e253-e275
MissingFormLabel
- 11
Reid SD,
Ladizinski B,
Lee K.
et al.
Update on necrobiosis lipoidica: a review of etiology, diagnosis, and treatment options.
J Am Acad Dermatol 2013; 69: 783-791
MissingFormLabel
- 12 Naumowicz M, Modzelewski S, Macko A. et al. A Breakthrough in the Treatment of Necrobiosis Lipoidica? Update on Treatment, Etiopathogenesis, Diagnosis, and Clinical Presentation. Int J Mol Sci 2024; 25
- 13
Peckruhn M,
Tittelbach J,
Elsner P.
Update: Treatment of necrobiosis lipoidica. J Dtsch Dermatol Ges 2017; 15: 151-157
MissingFormLabel
- 14
Janßen S,
Jansen TM.
Ulcerated necrobiosis lipoidica successfully treated with tofacitinib. Int J Dermatol
2022; 61: 739-741
MissingFormLabel
- 15
Karppinen JJ,
Kallio M,
Lappalainen K.
et al.
Clinical characteristics of Martorell hypertensive ischaemic leg ulcer. J Wound Care
2023; 32: 797-804
MissingFormLabel
- 16
Kraus LF,
Elsharkawi-Welt K,
Peters T.
et al.
Diagnostic Challenge of Bilateral Martorell Hypertensive Ischaemic Leg Ulcers. Acta
Derm Venereol 2021; 101: adv00457
MissingFormLabel
- 17
Pastor D,
Toutous Trellu L.
Martorell hypertensive ischemic ulcer: an atypical wound to know. Rev Med Suisse 2020;
16: 636-639
MissingFormLabel
- 18
Shanmugam VK,
Angra D,
Rahimi H.
et al.
Vasculitic and autoimmune wounds. J Vasc Surg Venous Lymphat Disord 2017; 5: 280-292
MissingFormLabel
- 19
Shavit E,
Alavi A,
Sibbald RG.
Vasculitis-What Do We Have to Know? A Review of Literature. Int J Low Extrem Wounds
2018; 17: 218-226
MissingFormLabel
- 20
Hoff NP,
Homey B.
Calciphylaxis. Pathogenesis and therapy. Hautarzt 2011; 62: 509-515
MissingFormLabel
- 21
Renner R,
Dissemond J,
Goerge T.
et al.
Analysis of the German DRG data for livedoid vasculopathy and calciphylaxis. J Eur
Acad Dermatol Venereol 2017; 31: 1884-1889
MissingFormLabel
- 22
Weishaupt C,
Strölin A,
Kahle B.
et al.
Anticoagulation with rivaroxaban for livedoid vasculopathy (RILIVA): a multicentre,
single-arm, open-label, phase 2a, proof-of-concept trial. Lancet Haematol 2016; 3:
e72-e79
MissingFormLabel
- 23
Schiffmann ML,
Dissemond J,
Erfurt-Berge C.
et al.
German S1 guideline: diagnosis and treatment of livedovasculopathy. J Dtsch Dermatol
Ges 2021; 19: 1668-1678
MissingFormLabel
- 24
Misciali C,
Dika E,
Fanti PA.
et al.
Frequency of malignant neoplasms in 257 chronic leg ulcers. Dermatol Surg 2013; 39:
849-854
MissingFormLabel
- 25
Valesky EM,
Hach-Wunderle V,
Protz K.
et al.
Diagnosis and treatment of venous leg ulcers: S2k Guideline of the German Society
of Phlebology and Lymphology (DGPL) e.V. J Dtsch Dermatol Ges 2024; 22: 1039-1051
MissingFormLabel
- 26
Dissemond J.
Medications. A rare cause for leg ulcers. Hautarzt 2011; 62: 516-523
MissingFormLabel
- 27
Akanay-Diesel S,
Hoff NP,
Kürle S.
et al.
Sunitinib induced pyoderma gangrenosum-like ulcerations. Eur J Med Res 2011; 16: 491-494
MissingFormLabel
- 28
Best PJ,
Daoud MS,
Pittelkow MR.
et al.
Hydroxyurea-induced leg ulceration in 14 patients. Ann Intern Med 1998; 128: 29-32
MissingFormLabel
- 29
Soya E,
Makowski C,
Blaise S.
Leg ulcer induced by hydroxycarbamide in sickle cell disease: What is the therapeutic
impact?. Int Wound J 2019; 16: 897-902
MissingFormLabel