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MSK – Muskuloskelettale Physiotherapie 2025; 29(03): 139-144
DOI: 10.1055/a-2564-8180
DOI: 10.1055/a-2564-8180
Schwerpunkt | Vertiefung
Sarkopenie – eine chronisch degenerative Muskelerkrankung in jedem Alter

Die Sarkopenie ist eine chronisch progressive Erkrankung des Organs Muskulatur. Sie beeinträchtigt die physische Leistungsfähigkeit, die Mobilität und die Gebrechlichkeit im Alter. Als Folge einer chronischen physischen Inaktivität kann sie allerdings auch schon in frühen Lebensspannen auftreten. Die einzige Intervention zur Prävention oder Therapie ist das Training, das zugleich den ursächlich schwelenden chronischen, generalisierten, nicht schmerzhaften Entzündungsprozess positiv beeinflusst.
Publication History
Article published online:
18 July 2025
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Literatur
- 1 Barbalho SM, Flato UAP, Tofano RJ. et al. Physical Exercise and Myokines: Relationships with Sarcopenia and Cardiovascular Complications. Int J Mol Sci 2020; 21: 3607
- 2 Chen LK, Liu LK, Woo J. et al. Sarcopenia in Asia: Consensus Report of the Asian Working Group for Sarcopenia. J Am Med Dir Assoc 2014; 15: 95-101
- 3 Chen LK, Woo J, Assantachai P. et al. Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment. J Am Med Dir Assoc 2020; 21: 300-307.e2
- 4 Cruz-Jentoft AJ, Baeyens JP, Bauer JM. et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing 2010; 39: 412-423
- 5 Cruz-Jentoft AJ, Bahat G, Bauer J. et al. Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 2019; 48: 16-31
- 6 Studenski SA, Peters KW, Alley DE. et al. The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates. J Gerontol A Biol Sci Med Sci 2014; 69: 547-58
- 7 Sayer AA, Cruz-Jentoft A. Sarcopenia definition, diagnosis and treatment: consensus is growing. Age Ageing 2022; 51: afac220
- 8 Laube W. Sensomotorik und Schmerz. Wechselwirkung von Bewegungsreizen und Schmerzempfinden. Berlin – Heidelberg: Springer; 2020
- 9 Laube W. Mentale Gesundheit und physische Aktivität. Manuelle Medizin 2022; 60: 13-21
- 10 Laube W. Gesundheitliche Vorteile durch Krafttraining. Einfluss auf das Risiko für chronische Erkrankungen und die Mortalität. Manuelle Medizin 2022; 60: 30-32
- 11 Laube W. Die Muskulatur – das „signalstoffgestützte periphere Zentrum“ adaptiver Wirkungen. Manuelle Medizin 2022; 60: 104-106
- 12 Laube W. Schmerztherapie ohne Medikamente – Leitfaden zur endogenen Schmerzhemmung für Ärzte und Therapeuten. Berlin – Heidelberg. Springer; 2022
- 13 Laube W. Bewegungsmangel. Dekonditionierung, Krankheit, Schmerzen, Alter. Berlin – Heidelberg. Springer; 2023
- 14 Goodpaster BH, Park SW, Harris TB. et al. The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study. J Gerontol A Biol Sci Med Sci 2006; 61: 1059-64
- 15 Delmonico MJ, Harris TB, Lee JS. et al. Alternative definitions of sarcopenia, lower extremity performance, and functional impairment with aging in older men and women. J Am Geriatr Soc 2007; 55: 769-74
- 16 Clark BC, Manini TM. Sarcopenia =/= dynapenia. J Gerontol A Biol Sci Med Sci 2008; 63: 829-34
- 17 Manini TM, Clark BC. Dynapenia and aging: an update. J Gerontol A Biol Sci Med Sci 2012; 67: 28-40
- 18 Gandham A, Gregori G, Johansson L. et al. Sarcopenia definitions and their association with fracture risk in older Swedish women. J Bone Miner Res 2024; 39: 453-461
- 19 Bijlsma AY, Meskers CG, Ling CH. et al. Defining sarcopenia: the impact of different diagnostic criteria on the prevalence of sarcopenia in a large middle aged cohort. Age (Dordr) 2013; 35: 871-81
- 20 Kim WJ, Kim KJ, Song DG. et al. Sarcopenia and Back Muscle Degeneration as Risk Factors for Back Pain: A Comparative Study. Asian Spine J 2020; 14: 364-372
- 21 Landi F, Calvani R, Martone AM. et al. Normative values of muscle strength across ages in a 'real world' population: results from the longevity check-up 7+ project. J Cachexia Sarcopenia Muscle 2020; 11: 1562-1569
- 22 Donini LM, Busetto L, Bischoff SC. et al. Definition and Diagnostic Criteria for Sarcopenic Obesity: ESPEN and EASO Consensus Statement. Clin Nutr 2022; 41: 990-1000
- 23 Wallengren O, Bosaeus I, Frändin K. et al. Comparison of the 2010 and 2019 diagnostic criteria for sarcopenia by the European Working Group on Sarcopenia in Older People (EWGSOP) in two cohorts of Swedish older adults. BMC Geriatr 2021; 21: 600
- 24 Fernandes LV, Paiva AEG, Silva ACB. et al. Prevalence of sarcopenia according to EWGSOP1 and EWGSOP2 in older adults and their associations with unfavorable health outcomes: a systematic review. Aging Clin Exp Res 2022; 34: 505-514
- 25 Petermann-Rocha F, Balntzi V, Gray SR. et al. Global prevalence of sarcopenia and severe sarcopenia: a systematic review and meta-analysis. J Cachexia Sarcopenia Muscle 2022; 13: 86-99
- 26 Jung HN, Jung CH, Hwang YC. Sarcopenia in youth. Metabolism 2023; 144: 155557
- 27 Ooi PH, Thompson-Hodgetts S, Pritchard-Wiart L. et al. Pediatric Sarcopenia: A Paradigm in the Overall Definition of Malnutrition in Children. ? JPEN J Parenter Enteral Nutr 2020; 44: 407-418
- 28 Mager DR, Hager A, Gilmour S. Challenges and physiological implications of sarcopenia in children and youth in health and disease. Curr Opin Clin Nutr Metab Care 2023; 26: 528-533
- 29 Pinti MV, Fink GK, Hathaway QA. et al. Mitochondrial dysfunction in type 2 diabetes mellitus: an organ-based analysis. Am J Physiol Endocrinol Metab 2019; 316: E268-E285
- 30 Tsuzuki T, Kobayashi H, Yoshihara T. et al. Attenuation of exercise-induced heat shock protein 72 expression blunts improvements in whole-body insulin resistance in rats with type 2 diabetes. Cell Stress Chaperones 2017; 22: 263-269
- 31 Golabi P, Gerber L, Paik JM. et al. Contribution of sarcopenia and physical inactivity to mortality in people with non-alcoholic fatty liver disease. JHEP Rep 2020; 2: 100171
- 32 Li R, Lin S, Tu J. et al. Establishment and evaluation of a novel practical tool for the diagnosis of pre-sarcopenia in young people with diabetes mellitus. J Transl Med 2023; 21: 393
- 33 Srikanthan P, Karlamangla AS. Relative muscle mass is inversely associated with insulin resistance and prediabetes. Findings from the third National Health and Nutrition Examination Survey. J Clin Endocrinol Metab 2011; 96: 2898-903
- 34 Chen S, Han H, Jin J. et al. Osteoarthritis and sarcopenia-related traits: the cross-sectional study from NHANES 2011-2014 and Mendelian randomization study. J Orthop Surg Res 2023; 18: 502
- 35 Zhang L, Zhang C, Zhang J. et al. A Bidirectional Mendelian Randomization Study of Sarcopenia-Related Traits and Knee Osteoarthritis. Clin Interv Aging 2023; 18: 1577-1586
- 36 Jin Z, Wang R, Jin L. et al. Causal relationship between sarcopenia with osteoarthritis and the mediating role of obesity: a univariate, multivariate, two-step Mendelian randomization study. BMC Geriatr 2024; 24: 469
- 37 Yang J, Liu P, Wang S. et al. Causal relationship between sarcopenia and osteoarthritis: a bi-directional two-sample mendelian randomized study. Eur J Med Res 2023; 28: 327
- 38 Jia XM, Deng TT, Su H. et al. Genetic causality and site-specific relationship between sarcopenia and osteoarthritis: a bidirectional Mendelian randomization study. Front Genet 2024; 14: 1340245
- 39 Yan L, Ge H, Wang Z. et al. Roles of low muscle strength and sarcopenic obesity on incident symptomatic knee osteoarthritis: A longitudinal cohort study. PLoS One 2024; 19: e0311423
- 40 Lee D, Kang M. Correlation between Psoas Muscle Index and Degeneration of Spinal Back Muscle in Patients with Back Pain. Healthcare (Basel) 2021; 9: 1189
- 41 Goubert D, De Pauw R, Meeus M. et al. Lumbar muscle structure and function in chronic versus recurrent low back pain: a cross-sectional study. Spine J 2017; 17: 1285-1296
- 42 Bennett JL, Pratt AG, Dodds R. et al. Rheumatoid sarcopenia: loss of skeletal muscle strength and mass in rheumatoid arthritis. Nat Rev Rheumatol 2023; 19: 239-251
- 43 Shin A, Choi SR, Han M. et al. Association between sarcopenia defined as low lean mass by dual-energy X-ray absorptiometry and comorbidities of rheumatoid arthritis: Results of a nationwide cross-sectional health examination. Semin Arthritis Rheum 2022; 57: 152090
- 44 Brance ML, Di Gregorio S, Pons-Estel BA. et al. Prevalence of Sarcopenia and Whole-Body Composition in Rheumatoid Arthritis. J Clin Rheumatol 2021; 27: S153-S160
- 45 Guo X, Pei J, Wei Y. et al. Prevalence and risk factors of falls in adults with rheumatoid arthritis: A systematic review and meta-analysis. Semin Arthritis Rheum 2023; 60: 152186
- 46 Tekgoz E, Colak S, Ozalp Ates FS. et al. Sarcopenia in rheumatoid arthritis: Is it a common manifestation?. Int J Rheum Dis 2020; 23: 1685-1691
- 47 Silva FF, Machado GR, Ribeiro ACM. et al. Damaged bone microarchitecture by Trabecular Bone Score (TBS) and low appendicular muscle mass: main risk factors for vertebral and non-vertebral fractures in women with long-standing rheumatoid arthritis. Osteoporos Int 2024; 35: 819-830
- 48 Laube W.. Manuelle Therapie und die zerebralen Netzwerke der Schmerzkomponenten. Manuelle Medizin 2023; 61: 110-113
- 49 Brinjikji W, Luetmer PH, Comstock B. et al. Systematic literature review of imaging features of spinal degeneration in asymptomatic populations. AJNR Am J Neuroradiol 2015; 36: 811-6
- 50 Wang L, Zhang S.. Investigating the Causal Effects of Exercise-Induced Genes on Sarcopenia. Int J Mol Sci 2024; 25: 10773