[^99mTc]Tc-PSMA SPECT/CT is a promising tool in the staging of renal cell carcinoma

Introduction

Clear cell renal cell carcinoma (ccRCC) accounts for 94 % of metastasized renal cell carcinomas (RCC) [1] and frequently exhibits a strongly upregulated prostate-specific membrane antigen (PSMA) expression [2]. At primary diagnosis of RCC, regional lymph node metastases and distant metastases are present in 16 % and 15 % of cases, respectively [3]. The most common sites of distant metastases are lung (70 %), distant lymph nodes (45 %) and bone (32 %). In the staging of RCC, PSMA positron emission tomography/computed tomography (PET/CT) detects additional metastases in 25 % of cases and changes therapeutic management in 49 % [1]. In biochemical recurrence of prostate cancer, [^99mTc]Tc-MIP-1404 has confirmed detection rates similar to PSMA PET/CT [4]. Consequently, [^99mTc]Tc-based PSMA ligands are emerging as a potential alternative in order to ensure excellent healthcare service in circumstances where PSMA PET/CT is not accessible.

Publication History

Received: 01 April 2025

Accepted: 08 April 2025

Article published online:
12 May 2025

• References

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