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Semin Respir Crit Care Med 2025; 46(01): 020-030
DOI: 10.1055/a-2588-6965
Review Article

Next-Generation Pneumococcal Vaccines for Children and Adults

Rosario Menéndez
1   Hospital Universitari i Politècnic La Fe, Research Institute, Valencia, Spain
,
María Garces-Sanchez
2   Department of Health, Public Health, Valencia, Spain
› Institutsangaben
Funding None.
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Abstract

Streptococcus pneumoniae remains one of the leading causes of mortality and morbidity in children and in the elderly worldwide. Pneumococcal conjugated vaccines (PCVs) have reduced invasive and noninvasive pneumococcal disease in children and adults. However, challenges persist due to serotype replacement, epidemiological diversity, and global inequalities in vaccine access. The future of PCVs is structured around three major areas of innovation: expanding antigenic coverage, developing serotype-independent formulations, and introducing advanced technological platforms such as the multiple antigen presenting system. The challenge is to better improve immunogenicity beyond serotypes and to extend the global impact of vaccines with more equitable and effective global rates of vaccination.

Keywords

conjugated vaccines - pneumococcal disease - serotype replacement - Streptococcus pneumoniae - next-generation vaccines


Publikationsverlauf

Accepted Manuscript online:
16. April 2025

Artikel online veröffentlicht:
06. Juni 2025

© 2025. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 

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