With the goal to overcome the bio-physicochemical drawbacks of parent curcumin (CUR)
and to develop analogues with improved biological profiles and higher potencies, the
present account provides a review summary of the work in my laboratory on the synthesis
of structurally diverse libraries of curcuminoids (CURs), their in vitro bioassays, and computational docking studies. These efforts resulted in the discovery
of a subset of compounds with exceptional antiproliferative and apoptotic activity
that warrant further investigation.
Key words
novel curcuminoids - synthesis -
in vitro bioassay - anticancer activity - computational docking
