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DOI: 10.1055/a-2606-2105
From Metastases to Splenosis: Resolving SSR PET Pitfalls with Tc-99m-Labeled Denatured Red Blood Cell Scintigraphy
Von Metastasen zu Splenose: Diagnostische Fallstricke der SSR-PET durch Tc-99m-markierte denaturierte Erythrozytenszintigrafie aufgelöst
Introduction
Somatostatin receptor (SSR) PET/CT is highly sensitive in detecting neuroendocrine tumors, most commonly originating from pancreatic-gastrointestinal tract and lung but can produce false positives due to benign conditions like splenosis [1]. Splenosis, the autotransplantation of splenic tissue after trauma or splenectomy, can mimic metastases on imaging [2]. Tc-99m-labeled denatured red blood cell scintigraphy is a reliable method to confirm ectopic splenic tissue, preventing unnecessary invasive procedures. However, literature on this diagnostic challenge is rare, underscoring the need for greater awareness of benign SSR PET/CT uptake patterns to avoid misdiagnosis. This case demonstrates the role of spleen scintigraphy in clarifying SSR PET/CT findings in a patient with lung carcinoid.
Publication History
Received: 12 April 2025
Accepted: 09 May 2025
Article published online:
06 August 2025
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