Inflammatory Myofibroblastic Tumor of the Colon: A Rare Aggressive Course

Introduction

Inflammatory myofibroblastic tumors (IMTs) are usually benign soft-tissue tumors that primarily occur in children and adolescents [1].

IMTs can occur in almost all regions of the body, with the lung, greater omentum, mesentery, and soft tissues being particularly susceptible. Abdominal IMTs are more common in children and adolescents, while pulmonary IMTs are primarily seen in adults [2].

IMTs are also referred to as an inflammatory pseudotumors, pseudosarcomatous myofibroblastic lesions, or plasma cell granulomas. All of these terms describe a dominant spindle cell proliferation with a variable inflammatory component. These spindle cells are myofibroblasts. Therefore, the term IMT is preferred even if other terms continue to be used. Anaplastic lymphoma kinase (ALK) gene expression is seen in approximately half of cases. The prognosis is usually good but there is a risk of recurrence in the case of abdominal tumors [3]. To date, only individual cases of malignant courses have been documented in the literature [2].

Publikationsverlauf

Eingereicht: 15. Oktober 2024

Angenommen nach Revision: 13. Mai 2025

Artikel online veröffentlicht:
30. Juni 2025

• References

• 1 Hammel A, Schönnagel BP, Herrmann J. Inflammatorischer myofibroblastischer Tumor: ungewöhnliche Differenzialdiagnose einer Lobärpneumonie im Röntgenthorax. RoFo 2017; 189: 767-768
• 2 Narla LD, Newman B, Spottswood SS. et al. Inflammatory pseudotumor. RadioGraphics 2003; 23: 719-729
• 3 Petersen I. The new WHO classification and recent results in soft tissue tumor pathology. Pathologe 2013; 34: 436-448
• 4 Leuschner I. Inflammatory myofibroblastic tumor. Pathologe 2010; 31: 106-108