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Synlett
DOI: 10.1055/a-2627-8548
DOI: 10.1055/a-2627-8548
Letter
Lewis Acid-Catalyzed Cyanomethylation of α,β-Unsaturated Keto Esters and Activated Ketones Using Vinyl Azide as an Acetonitrile Equivalent
Supported by: Sichuan Science and Technology Program 2022JDJQ0013,2022NSFSC1232
Supported by: National Natural Science Foundation of China 2022JDJQ0013,2022NSFSC1232

Abstract
Lewis acid-catalyzed cyanomethylation reactions of α,β-unsaturated ketoesters and ketoamides with α-isopropanol vinyl azide were reported. The corresponding cyanoalkylated products were obtained in 40–97% and 45–96% yields, respectively, through 1,4- and 1,2-addition pathways.
Publication History
Received: 08 May 2025
Accepted after revision: 04 June 2025
Accepted Manuscript online:
04 June 2025
Article published online:
24 July 2025
© 2025. Thieme. All rights reserved.
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