Subscribe to RSS
DOI: 10.1055/a-2659-7126
The Clinical Pearls and Pitfalls of Using the Symani System in Microsurgery

Abstract
Background
The improved stability and controllability of robotics has the potential to expand the spectrum of reconstructive surgery. Until recently, however, no robot was designed specifically for microsurgery. The present study aims to summarize the clinical pearls and pitfalls of utilizing the Symani Surgical System in microsurgical practice.
Methods
The PubMed Database was queried using the search term “Symani Robot System” from inception until January 2025. Data regarding demographics, study design, technique, and surgical outcomes were extracted from the full text by two independent reviewers.
Results
In the present analysis, 21 publications encompassing the results of 397 patients (range: 1–100) and 642 robotic anastomoses were included. Of the 335 patients included in the studies that reported complication rates, pooled analysis yielded an overall complication rate of 14.03% (n = 47) and a partial or complete flap loss rate of 2.09% (n = 7). Of 642 robotic total anastomoses, only 1.24% (n = 8) required a transition to a manual approach. A total of 19 groups (90.47%) reported high precision of Symani, 15 (71.43%) highlighted improved surgical access to deeper anatomical fields, and 12 (57.15%) reported enhanced microsurgical ergonomics. Regarding limitations, 13 (61.90%) cited the expense of the system, 5 (23.81%) reported a lack of haptic feedback, 5 (23.81%) identified instrument “stickiness” as a factor slowing operations, and 3 (14.29%) highlighted the need for improved grip. The learning curve associated with Symani was discussed in 15 studies (71.43%).
Conclusion
The results of the present literature review demonstrate that the Symani robot offers numerous benefits that will help advance the field of microsurgery. It provides complete tremor elimination, motion scaling, and improved operative ergonomics, leading to patent anastomosis and complication rates comparable to a traditional manual approach. However, more data are needed before widespread clinical implementation to determine whether the increased precision and controllability outweigh the cost and learning curve.
Lay Summary
The present study highlights the use of the Symani Surgical System, a novel robotic system designed specifically for microsurgery. Symani offers increased precision, dexterity, controllability, and numerous benefits that will help advance the field.
Keywords
robotics microsurgery - Symani Surgical System - robotic lymphatic surgery - robotic supermicrosurgeryPublication History
Received: 28 April 2025
Accepted: 24 June 2025
Article published online:
14 August 2025
© 2025. Thieme. All rights reserved.
Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA
-
References
- 1 Buncke Jr HJ, Schulz WP. Experimental digital amputation and reimplantation. Plast Reconstr Surg 1965; 36 (01) 62-70
- 2 Tamai S. History of microsurgery. Plast Reconstr Surg 2009; 124 (6, Suppl): e282-e294
- 3 Yamamoto T. Onco-reconstructive supermicrosurgery. Eur J Surg Oncol 2019; 45 (07) 1146-1151
- 4 Hong JPJ, Song S, Suh HSP. Supermicrosurgery: principles and applications. J Surg Oncol 2018; 118 (05) 832-839
- 5 Selber JC. Can I make robotic surgery make sense in my practice?. Plast Reconstr Surg 2017; 139 (03) 781e-792e
- 6 van Mulken TJM, Schols RM, Qiu SS. et al. Robotic (super) microsurgery: feasibility of a new master-slave platform in an in vivo animal model and future directions. J Surg Oncol 2018; 118 (05) 826-831
- 7 Mattos LS, Caldwell DG, Peretti G, Mora F, Guastini L, Cingolani R. Microsurgery robots: addressing the needs of high-precision surgical interventions. Swiss Med Wkly 2016; 146: w14375
- 8 Ruccia F, Mavilakandy A, Imtiaz H. et al. The application of robotics in plastic and reconstructive surgery: a systematic review. Int J Med Robot 2024; 20 (04) e2661
- 9 Bishop SN, Selber JC. Minimally invasive robotic breast reconstruction surgery. Gland Surg 2021; 10 (01) 469-478
- 10 van Mulken TJM, Schols RM, Scharmga AMJ. et al; MicroSurgical Robot Research Group. First-in-human robotic supermicrosurgery using a dedicated microsurgical robot for treating breast cancer-related lymphedema: a randomized pilot trial. Nat Commun 2020; 11 (01) 757
- 11 Tan YPA, Liverneaux P, Wong JKF. Current limitations of surgical robotics in reconstructive plastic microsurgery. Front Surg 2018; 5: 22
- 12
Page MJ,
McKenzie JE,
Bossuyt PM.
et al.
The PRISMA 2020 statement: an updated guideline for reporting systematic reviews.
BMJ 2021; 372 (71) n71
MissingFormLabel
- 13 Weinzierl A, Barbon C, Gousopoulos E. et al. Benefits of robotic-assisted lymphatic microsurgery in deep anatomical planes. JPRAS Open 2023; 37: 145-154
- 14 Lindenblatt N, Grünherz L, Wang A. et al. Early experience using a new robotic microsurgical system for lymphatic surgery. Plast Reconstr Surg Glob Open 2022; 10 (01) e4013
- 15 Grünherz L, Weinzierl A, Puippe GD. et al. First-in-human use of a microsurgical robotic system for central lymphatic reconstruction. Plast Reconstr Surg Glob Open 2023; 11 (12) e5484
- 16 von Reibnitz D, Weinzierl A, Barbon C. et al. 100 anastomoses: a two-year single-center experience with robotic-assisted micro- and supermicrosurgery for lymphatic reconstruction. J Robot Surg 2024; 18 (01) 164
- 17 Lilja C, Thomsen JB, Sørensen JA. Robot-assisted lymphovenous anastomosis surgery for lymphocele in the groin. BMJ Case Rep 2024; 17 (05) e260562
- 18 Struebing F, Bigdeli A, Weigel J. et al. Robot-assisted microsurgery: lessons learned from 50 consecutive cases. Plast Reconstr Surg Glob Open 2024; 12 (03) e5685
- 19 Besmens IS, Politikou O, Giovanoli P, Calcagni M, Lindenblatt N. Robotic microsurgery in extremity reconstruction—experience with a novel robotic system. Surg Innov 2024; 31 (01) 42-47
- 20 Barbon C, Grünherz L, Uyulmaz S, Giovanoli P, Lindenblatt N. Exploring the learning curve of a new robotic microsurgical system for microsurgery. JPRAS Open 2022; 34: 126-133
- 21 Dastagir N, Obed D, Tamulevicius M, Dastagir K, Vogt PM. The use of the Symani Surgical System® in emergency hand trauma care. Surg Innov 2024; 31 (05) 460-465
- 22 Vollbach FH, Bigdeli AK, Struebing F, Weigel JL, Gazyakan E, Kneser U. Using a microsurgical robotic platform for in-flap anastomosis in autologous bipedicular breast reconstruction. Plast Reconstr Surg Glob Open 2024; 12 (01) e5511
- 23 Innocenti M, Malzone G, Menichini G. First-in-human free flap tissue reconstruction using a dedicated microsurgical robotic platform. Plast Reconstr Surg 2023; 151 (05) 1078-1082
- 24 Beier JP, Hackenberg S, Boos AM, Modabber A, Duong Dinh TA, Hölzle F. First series of free flap reconstruction using a dedicated robotic system in a multidisciplinary microsurgical center. Plast Reconstr Surg Glob Open 2023; 11 (09) e5240
- 25 Schäfer B, Bahm J, Beier JP. Nerve transfers using a dedicated microsurgical robotic system. Plast Reconstr Surg Glob Open 2023; 11 (08) e5192
- 26 Tolksdorf K, Hohberger FS, Ernst C, Tietz S, Schultze-Mosgau S, Tautenhahn F. First experience using a novel microsurgical robotic device for free flap surgery in cranio- and maxillofacial surgery. J Craniomaxillofac Surg 2024; 52 (06) 704-706
- 27 Aman M, Struebing F, Weigel J. et al. Technical strategies and learning curve in robotic-assisted peripheral nerve surgery. Plast Reconstr Surg Glob Open 2024; 12 (10) e6221
- 28 Struebing F, Boecker A, Vollbach F. et al. Robot-assisted microsurgery: a single-center experience of 100 cases. J Robot Surg 2024; 19 (01) 28
- 29 Struebing F, Bigdeli AK, Boecker A, Weigel J, Kneser U, Gazyakan E. Hands-on robotic microsurgery: robotic-assisted free flap reconstruction of the upper extremity. J Clin Med 2024; 13 (23) 7450
- 30 Könneker S, Watson JA, Weinzierl A. et al. Advances in reconstructive robotic microsurgery in the extremity. J Craniofac Surg 2025; 36 (01) 354-357
- 31 Grünherz L, Weinzierl A, Gutschow CA. et al. Robotic-assisted lymphovenous anastomosis of the central lymphatic system. Plast Reconstr Surg Glob Open 2024; 12 (09) e6164
- 32 Wellenbrock S, Ozturk M, Sohn M. et al. Robotic-assisted microsurgery in gender-affirming phalloplasty. Ann Plast Surg 2025; 94 (01) 2-4
- 33 Gorji S, Wessel K, Dermietzel A. et al. Fully telemetric robotic microsurgery: clinical experience with 23 cases. Microsurgery 2024; 44 (06) e31227
- 34 Alamoudi U, Ghanem T. Solution to vessels mismatch in microsurgery: vertical arteriotomy technique. Laryngoscope Investig Otolaryngol 2021; 6 (06) 1321-1324
- 35 Xiong L, Gazyakan E, Kremer T. et al. Free flaps for reconstruction of soft tissue defects in lower extremity: a meta-analysis on microsurgical outcome and safety. Microsurgery 2016; 36 (06) 511-524
- 36 Abdulbaki H, Ha PK, Knott PD. et al. Postoperative inpatient surgical complications following head and neck microvascular free tissue transfer. Head Neck 2024; 46 (10) 2432-2439
- 37 Mehrara BJ, Santoro TD, Arcilla E, Watson JP, Shaw WW, Da Lio AL. Complications after microvascular breast reconstruction: experience with 1195 flaps. Plast Reconstr Surg 2006; 118 (05) 1100-1109
- 38 Kwok AC, Agarwal JP. An analysis of free flap failure using the ACS NSQIP database. Does flap site and flap type matter?. Microsurgery 2017; 37 (06) 531-538
- 39 Lakhiani C, Fisher SM, Janhofer DE, Song DH. Ergonomics in microsurgery. J Surg Oncol 2018; 118 (05) 840-844
- 40 Khansa I, Khansa L, Westvik TS, Ahmad J, Lista F, Janis JE. Work-related musculoskeletal injuries in plastic surgeons in the United States, Canada, and Norway. Plast Reconstr Surg 2018; 141 (01) 165e-175e
- 41 Belykh E, Onaka NR, Abramov IT. et al. Systematic review of factors influencing surgical performance: practical recommendations for microsurgical procedures in neurosurgery. World Neurosurg 2018; 112: e182-e207
- 42 Onoda S, Satake T, Hamada E. Super-microsurgery technique for lymphaticovenular anastomosis. J Vasc Surg Venous Lymphat Disord 2023; 11 (01) 177-181
- 43 Lee ZH, Daar DA, Stranix JT. et al. Risk factors for microvascular free flaps in pediatric lower extremity trauma. Microsurgery 2020; 40 (01) 44-50
- 44 Maegawa J, Yabuki Y, Tomoeda H, Hosono M, Yasumura K. Outcomes of lymphaticovenous side-to-end anastomosis in peripheral lymphedema. J Vasc Surg 2012; 55 (03) 753-760
- 45 Virós Porcuna D, Viña Soria C, Vila Poyatos J. et al. Oropharyngeal free flap reconstruction: transoral robotic surgery versus open approach. Laryngoscope Investig Otolaryngol 2023; 8 (06) 1564-1570
- 46 Fitzgerald O'Connor E, Rozen WM, Chowdhry M. et al. The microvascular anastomotic coupler for venous anastomoses in free flap breast reconstruction improves outcomes. Gland Surg 2016; 5 (02) 88-92
- 47 Wessel KJ, Stögner VA, Yu CT. et al. Preclinical performance of the combined application of two robotic systems in microsurgery: a two-center study. Plast Reconstr Surg Glob Open 2024; 12 (04) e5775
- 48 Guillaume VGJ, Ammo T, Leypold S. et al. Comparison of biomechanical and histopathological properties of robot-assisted anastomoses using the Symani surgical system® versus conventional anastomoses in a preclinical microsurgical model. J Reconstr Microsurg 2025; . Epub ahead of print
- 49 Cho J, Kim D, Kim T, Pak CJ, Suh HP, Hong JP. Further validating the robotic microsurgery platform through preclinical studies on rat femoral artery and vein. J Reconstr Microsurg 2025; . Epub ahead of print
- 50 Awad L, Reed B, Bollen E. et al. The emerging role of robotics in plastic and reconstructive surgery: a systematic review and meta-analysis. J Robot Surg 2024; 18 (01) 254
- 51 Hughes T, Rai B, Madaan S, Chedgy E, Somani B. The availability, cost, limitations, learning curve and future of robotic systems in urology and prostate cancer surgery. J Clin Med 2023; 12 (06) 2268