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DOI: 10.1055/a-2705-8764
Heterobenzylic C(sp3)─H Acylation of Isoindolinones via Photoinduced Intermolecular Hydrogen Atom Transfer Strategy
Authors
Funding Information The Department of Science and Technology-SERB, India (CRG/2021/001143) and the Seed grant-SG20210167, Vellore Institute of Technology, Vellore.
Supported by: Vellore Institute of Techmology SG20210167
Supported by: Council of Scientific and Industrial Research (CSIR), New Delhi, India 09/0844(18215)/2024-EMR-I
Abstract
Heterobenzylic C(sp3)−H functionalization of isoindolinones remains challenging yet highly desirable. Herein, we present a photo-induced hydrogen atom transfer (HAT) strategy for heterobenzylic C(sp3)−H acylation of isoindolinones using acyl azolium salts under mild reaction conditions. This metal-free protocol offers excellent functional group compatibility and avoids the usage of Lewis acids or oxidants, providing a sustainable and efficient approach to C–H acylation.
Publication History
Received: 12 June 2025
Accepted after revision: 28 August 2025
Accepted Manuscript online:
19 September 2025
Article published online:
24 October 2025
© 2025. Thieme. All rights reserved.
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