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Endoscopy
DOI: 10.1055/a-2724-3905
Systematic Review

Endoscopic papillectomy for ampullary lesions: pooled analysis with meta-regression analysis of outcomes

Authors

  • Marco Spadaccini

     1   Gastroenterology and Digestive Endoscopy, IRCSS Humanitas Research Hospital, Rozzano, Italy
     2   Department of Biomedical Sciences, Humanitas University, Milan, Italy

  • Gianluca Franchellucci

     2   Department of Biomedical Sciences, Humanitas University, Milan, Italy
     3   IBD Unit, IRCSS Humanitas Research Hospital, Rozzano, Italy

  • Matteo Colombo

     2   Department of Biomedical Sciences, Humanitas University, Milan, Italy

  • Cecilia Binda 

     4   Forlì-Cesena Hospitals, Gastroenterology and Digestive Endoscopy Unit, Forlì-Cesena, Italy

  • Maria Terrin

     2   Department of Biomedical Sciences, Humanitas University, Milan, Italy

  • Giacomo Marcozzi

     1   Gastroenterology and Digestive Endoscopy, IRCSS Humanitas Research Hospital, Rozzano, Italy
     2   Department of Biomedical Sciences, Humanitas University, Milan, Italy

  • Valeria Poletti 

     1   Gastroenterology and Digestive Endoscopy, IRCSS Humanitas Research Hospital, Rozzano, Italy
     2   Department of Biomedical Sciences, Humanitas University, Milan, Italy

  • Marta Andreozzi

     2   Department of Biomedical Sciences, Humanitas University, Milan, Italy

  • Alessandro De Marco

     5   Endoscopy Unit, Humanitas Gavazzeni, Bergamo, Italy

  • Roberto De Sire 

     1   Gastroenterology and Digestive Endoscopy, IRCSS Humanitas Research Hospital, Rozzano, Italy

  • Daryl Ramai

     6   Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Boston, Massachusetts, USA

  • Silvia Carrara

     1   Gastroenterology and Digestive Endoscopy, IRCSS Humanitas Research Hospital, Rozzano, Italy
     2   Department of Biomedical Sciences, Humanitas University, Milan, Italy

  • Cesare Hassan 

     1   Gastroenterology and Digestive Endoscopy, IRCSS Humanitas Research Hospital, Rozzano, Italy
     2   Department of Biomedical Sciences, Humanitas University, Milan, Italy

  • Benedetto Mangiavillano

     1   Gastroenterology and Digestive Endoscopy, IRCSS Humanitas Research Hospital, Rozzano, Italy

  • Alessandro Fugazza 

     2   Department of Biomedical Sciences, Humanitas University, Milan, Italy

  • Amrita Sethi

     7   Gastroenterology and Hepatology, Columbia Presbyterian Medical Center, New York, New York, USA

  • Carlo Fabbri

     4   Forlì-Cesena Hospitals, Gastroenterology and Digestive Endoscopy Unit, Forlì-Cesena, Italy

  • Antonio Facciorusso 

     8   Gastroenterology Unit, Department of Experimental Medicine, University of Salento, Lecce, Italy

  • Andrea Anderloni 

     9   Gastroenterology and Digestive Endoscopy Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

  • Alessandro Repici

     1   Gastroenterology and Digestive Endoscopy, IRCSS Humanitas Research Hospital, Rozzano, Italy
     2   Department of Biomedical Sciences, Humanitas University, Milan, Italy
    • Endoscopic Papillectomy Study Group
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Abstract

Background Endoscopic papillectomy is a viable treatment option for ampullary lesions. While many studies have reported low morbidity and acceptable outcomes, early attempts to pool data from these initial experiences have produced conflicting conclusions regarding key technical aspects. To address these uncertainties, we conducted a systematic review and pooled analysis to evaluate the safety and effectiveness of endoscopic papillectomy for ampullary lesions, identifying factors that may influence outcomes.

Methods Electronic databases (Medline, Scopus, and Embase) were searched up to September 2024. Studies that included patients with endoscopically resected ampullary lesions were eligible. Effectiveness and safety outcomes were pooled by means of a random-effects model to obtain a proportion with 95 %CI. Subgroup analysis and univariable meta-regression analyses were conducted to explore potential factors affecting outcomes.

Results 61 studies (4935 lesions) published between 2002 and 2024 were analyzed. Complete resection was achieved in 85.9 % of cases, though intraductal involvement limited success. The recurrence rate was 15.2 %; however, the majority of patients (92.4 %) were managed endoscopically without surgery. The pooled adverse event rate was 30.0 %, with bleeding (12.8 %) and post-procedural pancreatitis (11.2 %) being the most common complications. Prophylactic stenting reduced pancreatitis risk, while intraductal involvement increased perforation risk. Adjunctive treatments for intraductal involvement posed an increased risk of papillary stricture.

Conclusion Endoscopic papillectomy is a safe and effective treatment for ampullary lesions; however, lesions with intraductal extension pose a higher risk of incomplete resection and perforation, warranting careful evaluation of the benefit–risk balance in these cases. While prophylactic pancreatic stenting may reduce the incidence of post-procedural pancreatitis, optimizing strategies to minimize overall adverse events remains a key focus for future research.

Supplementary Material



Publication History

Received: 05 April 2025

Accepted after revision: 15 October 2025

Accepted Manuscript online:
15 October 2025

Article published online:
06 February 2026

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