Four-branched hybrid stent placement using multi-hole-covered self-expandable metallic stents for Bismuth type IV malignant hilar biliary obstruction

Hybrid stent placement during endoscopic retrograde cholangiopancreatography (ERCP), combining side-by-side (SBS) and stent-in-stent (SIS) techniques allows multi-segmental drainage of complex malignant hilar biliary obstruction (MHBO [1] [2]). Conventionally, uncovered self-expandable metallic stents (SEMSs) are used. A multi-hole-covered SEMS (MHSEMS; HANAROSTENT Biliary Multi-hole Benefit; M.I. Tech Co., Ltd, Pyeongtaek, South Korea) has recently been developed, designed with side holes to facilitate branch access, prevent side-branch occlusion, tumour ingrowth, and stent migration, while maintaining removability [3] [4] [5]. Here, we describe the first case of hybrid SBS and SIS placement using four MHSEMSs, achieving four-branched drainage in a bismuth type IV MHBO ([Fig. 1]).

Fig. 1 Bench-top photograph demonstration of hybrid stent placement combining side-by-side (SBS) and stent-in-stent (SIS) techniques using multi-hole-covered self-expandable metallic stents (MHSEMSs). a The first and second MHSEMSs were deployed into B3 + 4 and B6 in an SBS configuration, followed by the preparation of the third-branch insertion through the side hole. b The third MHSEMS was inserted into B2 using the SIS technique through the side hole of the left stent. c Preparation of the fourth-branch insertion through the side hole. d The fourth MHSEMS was inserted into B5 using the SIS technique through the side hole of the right stent, completing the four-branched hybrid stenting.

A 91-year-old woman with bismuth type IV hilar cholangiocarcinoma initially received two inside plastic stents for the drainage of the right and left hepatic ducts. She was readmitted with acute cholangitis. Bile cultures from both drained and previously undrained intrahepatic ducts (a right hepatic duct during inside stent placement and a left hepatic duct during endoscopic nasobiliary drainage [ENBD]; [Fig. 2]) yielded methicillin-resistant Staphylococcus aureus, necessitating four-branched drainage. Intravenous antibiotics were administered before stent exchange. During ERCP, all previously placed stents and ENBD tubes were removed. Two MHSEMSs (8 mm × 6 cm and 8 cm) were then deployed at B3+4 and B6 in a SBS configuration ([Fig. 3]). From each SBS stent, a guidewire was advanced through a side hole into the contralateral intrahepatic ducts (B2 and B5, respectively) using an uneven double-lumen cannula (PIOLAX, Kanagawa, Japan) and a radifocus guidewire (Terumo, Tokyo, Japan), which facilitated side-hole passage and enabled SIS deployment of an additional MHSEMS (8 mm × 6 cm; [Video 1], [Fig. 4]). Both technical and clinical success were achieved with no adverse events. The patient maintained an uneventful course without stent-related adverse events for 3 months.

Fig. 2 A fluoroscopic image before the current procedure showing two inside plastic stents placed at B5 (right anterior) and B6 (right posterior) ducts, and two 5 Fr endoscopic nasobiliary drainage tubes placed in B3 + 4 and B2.

Fig. 3 Side-by-side deployment of multi-hole-covered self-expandable metallic stents at B3 + 4 and B6 across the malignant hilar biliary obstruction.

Download Video

Hybrid side-by-side and stent-in-stent placement techniques using multi-hole-covered self-expandable metallic stents for four-branched drainage in a bismuth type IV malignant hilar biliary obstruction.Video 1

Fig. 4 A final fluoroscopic view demonstrating successful four-branched drainage: stent-in-stent placement from the B3+4 stent to B2 and from the B6 stent to B5, resulting in four fully expanded multi-hole-covered self-expandable metallic stents.

These findings suggest that the MHSEMS may expand therapeutic options for advanced MHBO.

Endoscopy_UCTN_Code_TTT_1AR_2AZ

Contributorsʼ Statement

Shinya Kawaguchi: Conceptualization, Data curation, Methodology, Writing – original draft, Writing – review & editing. Shinya Endo: Writing – review & editing. Tatsunori Satoh: Writing – review & editing.

Conflict of Interest

The authors declare that they have no conflict of interest.

• References

• 1 Yamada M, Ogura T, Okuda A. et al. Hybrid stent deployment combining side-by-side and stent-in-stent for advanced malignant hilar biliary obstruction. Endosc Int Open 2017; 5: E1231-E1235
• 2 Maruki Y, Hijioka S, Wu SYS. et al. Novel endoscopic technique for trisegment drainage in patients with unresectable hilar malignant biliary strictures (with video). Gastrointest Endosc 2020; 92: 763-769
• 3 Maruyama H, Tanoue K, Kurokawa T. et al. Stent-in-stent deployment above the papilla to treat malignant hepatic hilar biliary obstruction using novel fully covered multi-hole metal stent. Endoscopy 2023; 55 (Suppl. 01) E1062-E1064
• 4 Ogura T, Uba Y, Kanadani T. et al. Stent-in-stent deployment for malignant hilar obstruction using multi-hole stent can prevent tumor ingrowth during 6-month cholangioscopic follow-up. Endoscopy 2025; 57 (Suppl. 01) E99-E100
• 5 Toyonaga H, Hayashi T, Sasaki T. et al. Side-by-side and stent-in-stent combination placement of three multi-hole metallic stents for malignant hilar biliary obstruction. Endoscopy 2022; 54 (Suppl. 01) E556-E557

Publication History

Article published online:
15 January 2026